Nitric oxide synthase 3

BE0000263ProteinHumansNOS3

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway (PubMed:1378832). It is acted on by 54 drugs in DrugBank.

Gene name
NOS3
UniProtKB entry
P29474Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,203 residues · 133,274 Da
Also known as
1.14.13.39 · cNOS · Constitutive NOS · EC-NOS · Endothelial NOS

Resolves to

Protein
UniProtP29474UniProt nameNOS3_HUMAN
Gene
HGNCHGNC:7876NCBI Gene4846GenBank189212GeneCardsNOS3
Pharmacology
IUPHAR/GtoPdb1249KEGGhsa:4846
Structure
PDB1M9JPDB1M9KPDB1M9M
Drugs

What you can answer from here — as of September 03, 2024

54DrugsApproved to experimental, with action, bond type and pharmacological action
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5Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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20GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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140+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nitric oxide synthase 3, how selective are they, and which programs against it are still in active trials?

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