Xanthine dehydrogenase/oxidase

BE0002204ProteinHumansXDH

Key enzyme in purine degradation. It is acted on by 45 drugs in DrugBank.

Gene name
XDH
UniProtKB entry
P47989Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,333 residues · 146,423 Da
Also known as
XDHA

Resolves to

Protein
UniProtP47989UniProt nameXDH_HUMAN
Gene
HGNCHGNC:12805NCBI Gene7498GenBank10336525GeneCardsXDH
Pharmacology
IUPHAR/GtoPdb2646KEGGhsa:7498
Structure
PDB2CKJPDB2E1Q
Drugs

What you can answer from here — as of September 07, 2019

45DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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14Metabolic reactionsDrug transformations it catalyses, substrate to product
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17GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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122+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Xanthine dehydrogenase/oxidase, how selective are they, and which programs against it are still in active trials?

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