Intepirdine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Intepirdine
DrugBank Accession Number
DB12680
Background

Intepirdine has been used in trials studying the treatment of Alzheimer's Disease.

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 353.44
Monoisotopic: 353.119798038
Chemical Formula
C19H19N3O2S
Synonyms
  • Intepirdine
External IDs
  • RVT-101
  • SB-742457

Pharmacology

Indication

Not Available

Reduce drug development failure rates
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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as n-arylpiperazines. These are organic compounds containing a piperazine ring where the nitrogen ring atom carries an aryl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazinanes
Sub Class
Piperazines
Direct Parent
N-arylpiperazines
Alternative Parents
Aminoquinolines and derivatives / Benzenesulfonyl compounds / Dialkylarylamines / Pyridines and derivatives / Sulfones / Heteroaromatic compounds / Dialkylamines / Azacyclic compounds / Organic oxides / Hydrocarbon derivatives
Substituents
Amine / Aminoquinoline / Aromatic heteropolycyclic compound / Azacycle / Benzenesulfonyl group / Benzenoid / Dialkylarylamine / Heteroaromatic compound / Hydrocarbon derivative / Monocyclic benzene moiety
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
2IOB2M82HY
CAS number
607742-69-8
InChI Key
JJZFWROHYSMCMU-UHFFFAOYSA-N
InChI
InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
IUPAC Name
3-(benzenesulfonyl)-8-(piperazin-1-yl)quinoline
SMILES
O=S(=O)(C1=CC=CC=C1)C1=CN=C2C(C=CC=C2N2CCNCC2)=C1

References

General References
Not Available
PubChem Compound
11256720
PubChem Substance
347828884
ChemSpider
9431746
BindingDB
50318633
ChEMBL
CHEMBL1083390
ZINC
ZINC000043199965
Wikipedia
Intepirdine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentAlzheimer's Disease (AD)1
3TerminatedTreatmentAlzheimer's Disease (AD)1
2CompletedTreatmentAlzheimer's Disease (AD)4
2CompletedTreatmentAlzheimer's Disease (AD) / Dementia With Lewy Body Disease / Parkinsons Disease With Dementia (PDD)1
2CompletedTreatmentDementia With Lewy Body Disease1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.057 mg/mLALOGPS
logP2.04ALOGPS
logP2.66Chemaxon
logS-3.8ALOGPS
pKa (Strongest Basic)8.61Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area62.3 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity98.7 m3·mol-1Chemaxon
Polarizability37.33 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0009000000-98553d130f33d688bfb6
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udl-0709000000-23a6a299572e9946c41f
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0009000000-0cd6b9b0f3da08bd59bf
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0229000000-159b7541e5f8aaedbe3a
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a6r-1947000000-d69e688e9b9e85f7a7fd
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-01vo-2975000000-bec0f3e63f10e10c6e64
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-174.02068
predicted
DeepCCS 1.0 (2019)
[M+H]+176.37874
predicted
DeepCCS 1.0 (2019)
[M+Na]+183.01604
predicted
DeepCCS 1.0 (2019)

Drug created at October 20, 2016 23:35 / Updated at February 21, 2021 18:53