This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Asiaticoside
DrugBank Accession Number
DB14081
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 959.133
Monoisotopic: 958.513730292
Chemical Formula
C48H78O19
Synonyms
  • Asiaticosid
External IDs
  • BA 2742
  • BA-2742

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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International/Other Brands
Madecassol
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Centella Scar Ylang YlangAsiaticoside (0.06 g/15g) + Asiatic acid (0.045 g/15g) + Madecassic acid (0.045 g/15g)OintmentTopicalNoTS Co.,Ltd2016-12-012018-12-01US flag
Dr.Different CICA MetalAsiaticoside (0.012 g/100g) + Madecassoside (0.26 g/100g)CreamTopicalDareun Cosmetics Co., Ltd.2021-05-01Not applicableUS flag
Karatica Im Cica Essence PackAsiaticoside (0.01 g/100mL) + Asiatic acid (0.01 g/100mL) + Madecassic acid (0.01 g/100mL) + Madecassoside (0.01 g/100mL)LiquidTopicalKaratica Co., Ltd2019-08-17Not applicableUS flag
Troiareuke Acsen RecoveryAsiaticoside (0.009 g/25mL) + Asiatic acid (0.008 g/25mL) + Madecassic acid (0.008 g/25mL)CreamTopicalMk Universal Inc.2018-05-012018-12-01US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Centella Scar Ylang YlangAsiaticoside (0.06 g/15g) + Asiatic acid (0.045 g/15g) + Madecassic acid (0.045 g/15g)OintmentTopicalNoTS Co.,Ltd2016-12-012018-12-01US flag
Dr.Different CICA MetalAsiaticoside (0.012 g/100g) + Madecassoside (0.26 g/100g)CreamTopicalDareun Cosmetics Co., Ltd.2021-05-01Not applicableUS flag
Karatica Im Cica Essence PackAsiaticoside (0.01 g/100mL) + Asiatic acid (0.01 g/100mL) + Madecassic acid (0.01 g/100mL) + Madecassoside (0.01 g/100mL)LiquidTopicalKaratica Co., Ltd2019-08-17Not applicableUS flag
Troiareuke Acsen RecoveryAsiaticoside (0.009 g/25mL) + Asiatic acid (0.008 g/25mL) + Madecassic acid (0.008 g/25mL)CreamTopicalMk Universal Inc.2018-05-012018-12-01US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
PKO39VY215
CAS number
16830-15-2
InChI Key
WYQVAPGDARQUBT-FGWHUCSPSA-N
InChI
InChI=1S/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-60H,9-19H2,1-7H3/t20-,21+,22+,24-,25-,26-,27-,28-,29+,30+,31-,32-,33+,34-,35-,36-,37-,38-,39+,40-,41+,42+,44+,45+,46-,47-,48+/m1/s1
IUPAC Name
(2S,3R,4S,5S,6R)-6-({[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl (1S,2R,4aS,6aS,6bR,8aR,9R,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate
SMILES
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(=O)O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)[C@@]1(C)C[C@@H](O)[C@H](O)[C@@]2(C)CO

References

General References
Not Available
KEGG Drug
D07576
KEGG Compound
C15428
ChemSpider
10128466
BindingDB
23211
RxNav
18405
ChEBI
79928
ChEMBL
CHEMBL1684590
ZINC
ZINC000253529453

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
OintmentTopical
LiquidTopical
CreamTopical
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.798 mg/mLALOGPS
logP0.73ALOGPS
logP-0.54ChemAxon
logS-3.1ALOGPS
pKa (Strongest Acidic)11.75ChemAxon
pKa (Strongest Basic)-3.6ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count18ChemAxon
Hydrogen Donor Count12ChemAxon
Polar Surface Area315.21 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity232.55 m3·mol-1ChemAxon
Polarizability102.07 Å3ChemAxon
Number of Rings8ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at June 17, 2018 22:08 / Updated at June 12, 2020 16:53