Florilglutamic acid F-18
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Florilglutamic acid F-18
- DrugBank Accession Number
- DB15041
- Background
Florilglutamic acid F-18 is under investigation in clinical trial NCT02370563 (PET Imaging of Intracranial Cancers With 18F-FSPG).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 206.204
Monoisotopic: 206.093220602 - Chemical Formula
- C8H14FNO4
- Synonyms
- [F18] Florilglutamic Acid
- 18F-FSPG
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 92T1Y5X038
- CAS number
- 1196963-74-2
- InChI Key
- MKDNDKMECWBLOF-XUCPOOORSA-N
- InChI
- InChI=1S/C8H14FNO4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h5-6H,1-4,10H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1/i9-1
- IUPAC Name
- (2S,4S)-2-amino-4-[3-(¹⁸F)fluoropropyl]pentanedioic acid
- SMILES
- N[C@@H](C[C@H](CCC[18F])C(O)=O)C(O)=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 32698684
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Diagnostic B-Cell Lymphoma / Breast Cancer Stage IIIc / Carcinoma Breast Stage IV / Estrogen Receptor Negative / HER2 negative / Lung Cancer, Nonsmall Cell, Stage IIIA / Metastatic Renal Cell Carcinoma ( mRCC) / Progesterone Receptor Negative / Stage III Mesothelioma / Stage III Renal Cell Carcinoma / Stage IIIA Breast Cancer / Stage IIIB Non-Small Cell Lung Cancer / Stage IV Mesothelioma / Stage IV Non-small Cell Lung Cancer (NSCLC) / Stage IV Renal Cell Cancer / Triple Negative Breast Carcinoma 1 2 Completed Diagnostic Cigarette Smoking Behavior / Lung Carcinoma / Pulmonary Nodules, Solitary 1 2 Recruiting Diagnostic Cigarette Smokers / Current Smokers / Former Smoker / Pulmonary Nodules / Pulmonary Nodules, Multiple 1 2 Terminated Diagnostic Myocardial Inflammation / Sarcoidosis, Cardiac 1 1 Recruiting Diagnostic Adult Hepatocellular Carcinoma / Benign hepatic neoplasm / Cholangiocarcinoma / Hepatic Metastases / Resectable Hepatocellular Carcinoma 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 19.2 mg/mL ALOGPS logP -3 ALOGPS logP -2.4 Chemaxon logS -1 ALOGPS pKa (Strongest Acidic) 2.22 Chemaxon pKa (Strongest Basic) 9.53 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 100.62 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 45.3 m3·mol-1 Chemaxon Polarizability 19.38 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0900-0920000000-e4e92f2db4136cfed4eb Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0a4i-0490000000-41ec3084101e32663345 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-014i-0900000000-50b4b9422b8a1aab9f25 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-014i-9200000000-891c1fda517d2b8cbc8d Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-014l-9600000000-b04a31faa4d49a958055 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-00di-9100000000-e3311c10f41975548a77 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at May 20, 2019 14:44 / Updated at December 01, 2022 11:29