RAF proto-oncogene serine/threonine-protein kinase

BE0000036ProteinHumansRAF1

Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival... It is acted on by 22 drugs in DrugBank.

Gene name
RAF1
UniProtKB entry
P04049Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
648 residues · 73,051 Da
Also known as
2.7.11.1 · cRaf · Proto-oncogene c-RAF · RAF · Raf-1

Resolves to

Protein
UniProtP04049UniProt nameRAF1_HUMAN
Gene
HGNCHGNC:9829NCBI Gene5894GenBank35842GeneCardsRAF1
Pharmacology
IUPHAR/GtoPdb2184KEGGhsa:5894
Structure
PDB1C1YPDB1FAQPDB1FAR
Drugs

What you can answer from here — as of September 07, 2019

22DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
39Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
13GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
111+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on RAF proto-oncogene serine/threonine-protein kinase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In