Serine/threonine-protein kinase B-raf

BE0000634ProteinHumansBRAF

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). It is acted on by 26 drugs in DrugBank.

Gene name
BRAF
UniProtKB entry
P15056Swiss-Prot
Cellular location
Nucleus
Residues / weight
766 residues · 84,436 Da
Also known as
2.7.11.1 · BRAF1 · p94 · Proto-oncogene B-Raf · RAFB1

Resolves to

Protein
UniProtP15056UniProt nameBRAF_HUMAN
Gene
HGNCHGNC:1097NCBI Gene673GenBank41387220GeneCardsBRAF
Pharmacology
IUPHAR/GtoPdb1943KEGGhsa:673
Structure
PDB1UWHPDB1UWJPDB2FB8
Drugs

What you can answer from here — as of September 07, 2019

26DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
216Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
8GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
129+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Serine/threonine-protein kinase B-raf, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In