Pentaglobin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pentaglobin
Accession Number
DB15865
Description

Pentaglobin, also known as IgM-enriched immunoglobulin, falls under a group of polyclonal immunoglobulin preparations.1 It is comprised of immunoglobulin G (IgG) and immunoglobulin A (IgA) while also being enriched by immunoglobulin M (IgM).3

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Blood factors
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • IgM-enriched immunoglobulins
  • IVIgGM
External IDs
  • Pentaglobin

Pharmacology

Indication
Not Available
Contraindications & Blackbox Warnings
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Pharmacodynamics
Not Available
Mechanism of action

Pentaglobin has potential antibacterial and immunomodulatory properties where, compared to immunoglobulin treatments without IgM, pentaglobin may have an increased ability to eliminate infectious pathogens . The IgM in the preparation plays a role in complement activation and neutralization of bacterial endo- and exotoxins.3 Pentaglobin is used as an adjuvant in treatment of severe bacterial infections while it is also investigated against peritonitis, sepsis, and COVID-19.2

Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
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Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Chemical Identifiers

UNII
Not Available
CAS number
Not Available

References

General References
  1. Neilson AR, Burchardi H, Schneider H: Cost-effectiveness of immunoglobulin M-enriched immunoglobulin (Pentaglobin) in the treatment of severe sepsis and septic shock. J Crit Care. 2005 Sep;20(3):239-49. doi: 10.1016/j.jcrc.2005.03.003. [PubMed:16253792]
  2. Vaira M, Scuderi S, Costamagna D, Barone R, De Simone M: [Use of pentaglobin in the treatment of sepsis in the patient undergoing intraperitoneal hyperthermic chemotherapy]. Tumori. 2003 Jul-Aug;89(4 Suppl):296-7. [PubMed:12903625]
  3. National Cancer Institute: IgM-enriched Immunoglobulins (CUI CL563000) [Link]
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentNeonatal Sepsis / Very Low Birth Weight Baby1
4Unknown StatusTreatmentSepsis of the Newborn1
3Not Yet RecruitingPreventionInfant, Newborn, Diseases / Inflammatory Reaction / Neonatal Sepsis, Early-Onset / Very Low Birth Weight Infant1
3Not Yet RecruitingTreatmentHypoglobulinemia / Sepsis / Shock, Septic1
2CompletedTreatmentSevere Sepsis / Shock, Septic1
2Not Yet RecruitingTreatmentShock, Septic1
2SuspendedTreatmentPeritonitis / Sepsis1
Not AvailableCompletedNot AvailableRespiratory Distress Syndrome, Adult / Shock, Septic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created on September 21, 2020 07:56 / Updated on September 22, 2020 07:00

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