Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- DFV890
- DrugBank Accession Number
- DB16461
- Background
DFV890 is under investigation in multiple clinical trials for its efficacy, safety, and tolerability across various conditions: NCT06031844 (coronary heart disease with elevated hsCRP), NCT04886258 (symptomatic knee osteoarthritis), NCT06097663 (coronary heart disease and clonal hematopoiesis of indeterminate potential), NCT05552469 (myeloid diseases), NCT04868968 (familial cold autoinflammatory syndrome), and NCT04382053 (COVID-19 pneumonia).
- Type
- Small Molecule
- Groups
- Investigational
- Synonyms
- Not Available
- External IDs
- DFV890
- IFM-2427
Pharmacology
- Indication
Not Available
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Not Available
- Mechanism of action
DFV890 (previously known as IFM-2427) is a systemic NLRP3 antagonist: by blocking NLRP3 effects, IFM-2427 reduces inflammatory signalling and the assembly of multi-protein complexes that result from maturation of cytokines like IL-1, IL-18 and necrosis. This dampening of the NLRP3-initiated immune response allows other immune pathways to produce inflammatory responses to handle harmful pathogens and reduces the often negative downstream effects that occur as a result of NLRP3 activation. Novartis took over DFV890 when it purchased the biotech firm, IFM Tre. The compound is currently being tested in Phase 2 human clinical triasl for safety and efficacy in patients with COVID-19.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data2 Completed Treatment Coronavirus Disease 2019 (COVID‑19) / COVID 19 Pneumonia, Impaired Respiratory Function 1 somestatus stop reason just information to hide 2 Completed Treatment Familial Cold Autoinflammatory Syndrome (FCAS) 1 somestatus stop reason just information to hide 2 Recruiting Treatment Clonal Hematopoiesis of Indeterminate Potential (CHIP) / Coronary Heart Disease (CHD) 1 somestatus stop reason just information to hide 2 Recruiting Treatment Symptomatic Knee Osteoarthritis 1 somestatus stop reason just information to hide 1 Recruiting Treatment Myeloid Diseases 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at January 21, 2021 01:43 / Updated at July 26, 2024 04:51