Familial Cold Autoinflammatory Syndrome (FCAS) (DBCOND0034416)

Identifiers

Synonyms

Familial Cold Autoinflam Syn (FCAS) / Familial Cold Autoinflammatory Syndromes / Familial Cold Urticaria / Familial Cold Auto-inflammatory Syndrome / Familial Cold Autoinflammatory Syndrome / Cryopyrin-associated periodic syndromes / FCAS / Familial cold urticaria (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Canakinumab	An interleukin-1β blocker used to treat Periodic Fever Syndromes such as Cryopyrin-Associated Periodic Syndromes (CAPS) and Familial Mediterranean Fever (FMF), and also to treat active Systemic Juvenile Idiopathic Arthritis (SJIA).	Interleukin-1 betatarget
Rilonacept	An IL-1 inhibitor used to treat cryopyrin-associated periodic syndrome, a rare hereditary inflammatory disorder.	Interleukin-1 betatarget Interleukin-1 alphatarget Interleukin-1 receptor antagonist proteintarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01213641	Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) Patients	No drug interventions	Not Available	Not Available	completed
NCT06544018	Circadian Rhythm Deregulation in Patients With CAPS	No drug interventions	other	Not Available	not_yet_recruiting
NCT00214851	The Use of Kineret (Anakinra) in the Treatment of Familial Cold Urticaria	No drug interventions	treatment	1	completed
NCT00288704	Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS)	No drug interventions	treatment	3	completed
NCT00685373	Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease	Canakinumab	treatment	3	completed
NCT01576367	Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease	No drug interventions	treatment	3	completed
NCT04868968	Study of Safety, Tolerability and Efficacy of DFV890 in Participants With Familial Cold Auto-inflammatory Syndrome (FCAS)	No drug interventions	treatment	2	completed
NCT00887939	Pathogenesis of Physical Induced Urticarial Syndromes	No drug interventions	Not Available	Not Available	completed
NCT01302860	Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease	No drug interventions	treatment	3	completed
NCT00991146	Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase	No drug interventions	treatment	3	completed