Transient receptor potential cation channel subfamily V member 4

BE0009159ProteinHumansTRPV4

Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:16293632, PubMed:18695040, PubMed:18826956, PubMed:22526352, PubMed:23136043, PubMed:29899501). It is acted on by 8 drugs in DrugBank.

Gene name
TRPV4
UniProtKB entry
Q9HBA0Swiss-Prot
Cellular location
Cell membrane
Residues / weight
871 residues · 98,280 Da
Also known as
Osm-9-like TRP channel 4 · OTRPC4 · Transient receptor potential protein 12 · TRP12 · TrpV4

Resolves to

Protein
UniProtQ9HBA0UniProt nameTRPV4_HUMAN
Gene
HGNCHGNC:18083NCBI Gene59341GeneCardsTRPV4
Pharmacology
IUPHAR/GtoPdb510KEGGhsa:59341
Structure
PDB4DX1PDB4DX2PDB7AA5
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transient receptor potential cation channel subfamily V member 4, how selective are they, and which programs against it are still in active trials?

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