Dalpiciclib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Dalpiciclib
DrugBank Accession Number
DB17456
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 446.555
Monoisotopic: 446.24302423
Chemical Formula
C25H30N6O2
Synonyms
  • Cdk4/6 inhibitor shr6390
  • Pyrido(2,3-d)pyrimidin-7(8h)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(4-piperidinyl)-2-pyridinyl)amino)-
External IDs
  • SHR-6390

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
5ZHA5P4PFX
CAS number
1637781-04-4
InChI Key
SGJLSPUSUBJWHO-UHFFFAOYSA-N
InChI
InChI=1S/C25H30N6O2/c1-15-20-14-28-25(29-21-8-7-18(13-27-21)17-9-11-26-12-10-17)30-23(20)31(19-5-3-4-6-19)24(33)22(15)16(2)32/h7-8,13-14,17,19,26H,3-6,9-12H2,1-2H3,(H,27,28,29,30)
IUPAC Name
6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperidin-4-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one
SMILES
CC(=O)C1=C(C)C2=C(N=C(NC3=CC=C(C=N3)C3CCNCC3)N=C2)N(C2CCCC2)C1=O

References

General References
Not Available
ChemSpider
114951729
ChEMBL
CHEMBL4802161

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentAdvanced Breast Cancer2
3Enrolling by InvitationTreatmentHormone Receptor Positive,Human Epidermal Receptor 2 Negative, Node-positive, High Risk, Early Stage,Female Breast Cancer1
3RecruitingTreatmentAdvanced Breast Cancer1
2Active Not RecruitingTreatmentAdvanced Breast Cancer / Metastatic Breast Cancer1
2Active Not RecruitingTreatmentBreast Cancer1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0285 mg/mLALOGPS
logP2.34ALOGPS
logP2.76Chemaxon
logS-4.2ALOGPS
pKa (Strongest Acidic)10.44Chemaxon
pKa (Strongest Basic)9.79Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area100.11 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity127.7 m3·mol-1Chemaxon
Polarizability50.27 Å3Chemaxon
Number of Rings5Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at January 20, 2023 21:55 / Updated at January 21, 2023 13:36