Dalpiciclib
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Dalpiciclib
- DrugBank Accession Number
- DB17456
- Background
Not Available
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 446.555
Monoisotopic: 446.24302423 - Chemical Formula
- C25H30N6O2
- Synonyms
- Cdk4/6 inhibitor shr6390
- Pyrido(2,3-d)pyrimidin-7(8h)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(4-piperidinyl)-2-pyridinyl)amino)-
- External IDs
- SHR-6390
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 5ZHA5P4PFX
- CAS number
- 1637781-04-4
- InChI Key
- SGJLSPUSUBJWHO-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H30N6O2/c1-15-20-14-28-25(29-21-8-7-18(13-27-21)17-9-11-26-12-10-17)30-23(20)31(19-5-3-4-6-19)24(33)22(15)16(2)32/h7-8,13-14,17,19,26H,3-6,9-12H2,1-2H3,(H,27,28,29,30)
- IUPAC Name
- 6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperidin-4-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one
- SMILES
- CC(=O)C1=C(C)C2=C(N=C(NC3=CC=C(C=N3)C3CCNCC3)N=C2)N(C2CCCC2)C1=O
References
- General References
- Not Available
- External Links
- ChemSpider
- 114951729
- ChEMBL
- CHEMBL4802161
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Active Not Recruiting Treatment Advanced Breast Cancer 2 3 Enrolling by Invitation Treatment Hormone Receptor Positive,Human Epidermal Receptor 2 Negative, Node-positive, High Risk, Early Stage,Female Breast Cancer 1 3 Recruiting Treatment Advanced Breast Cancer 1 2 Active Not Recruiting Treatment Advanced Breast Cancer / Metastatic Breast Cancer 1 2 Active Not Recruiting Treatment Breast Cancer 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0285 mg/mL ALOGPS logP 2.34 ALOGPS logP 2.76 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 10.44 Chemaxon pKa (Strongest Basic) 9.79 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 100.11 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 127.7 m3·mol-1 Chemaxon Polarizability 50.27 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at January 20, 2023 21:55 / Updated at January 21, 2023 13:36