Caspase-1

BE0000444ProteinHumansCASP1

Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer... It is acted on by 13 drugs in DrugBank.

Gene name
CASP1
UniProtKB entry
P29466Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
404 residues · 45,158 Da
Also known as
3.4.22.36 · CASP-1 · ICE · IL-1 beta-converting enzyme · IL-1BC

Resolves to

Protein
UniProtP29466UniProt nameCASP1_HUMAN
Gene
HGNCHGNC:1499NCBI Gene834GenBank33793GeneCardsCASP1
Pharmacology
IUPHAR/GtoPdb1617KEGGhsa:834
Structure
PDB1BMQPDB1IBCPDB1ICE
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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31GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Caspase-1, how selective are they, and which programs against it are still in active trials?

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