TP-3654

DB18109InvestigationalSmall molecule

TP-3654: Overview.

Mechanism: Pharmacologically active on Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-3, and Serine/threonine-protein kinase pim-2
Curator reviewed
Formula / weight: C₂₂H₂₅F₃N₄O · 418.464 g/mol (avg)
Also known as: 2-(4-((3-(3-(trifluoromethyl)phenyl)imidazo(1,2-b)pyridazin-6-yl)amino)cyclohexyl)propan-2-ol · 2-(trans-4-((3-(3-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin6-yl)amino)cyclohexyl)propan-2-ol hydrochloride · 4-((3-(3-(trifluoromethyl)phenyl)imidazo(1,2-b)pyridazin-6-yl)amino) -trans-cyclohexyl)propan-2-ol
Code names: SGI-9481 · TP-3654

Resolves to

Compound

UNIIEOB0N7BOY4CAS1361951-15-6ChEMBLCHEMBL3975308

Structure

InChIKeyXRNVABDYQLHODA-JCNLHEQBSA-NSMILESCC(C)(O)[C@H]1CC[C@@H](CC1)NC1=NN2C(C=C1)=NC=C2C1=CC=CC(=C1)C(F)(F)F

Targets

P11309PIM1Q86V86PIM3Q9P1W9PIM2

Transporters

Q9UNQ0ABCG2

What you can answer from here — as of September 12, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

4Clinical trialsPhase, status and sponsor resolved per trial

8+ReferencesStructured and connected to the statements they support

Which drugs share a target with TP-3654, and which of those have an active Phase 3 trial?

Answer this in Biopharma OS Sign in to your account

Create a free account or log in to explore the full data card.

Log In Paid Account Log In