Serine/threonine-protein kinase pim-1

BE0001277ProteinHumansPIM1

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis (PubMed:15528381, PubMed:1825810, PubMed:31548394). It is acted on by 28 drugs in DrugBank.

Gene name
PIM1
UniProtKB entry
P11309Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
313 residues · 35,685 Da
Also known as
2.7.11.1

Resolves to

Protein
UniProtP11309UniProt namePIM1_HUMAN
Gene
HGNCHGNC:8986NCBI Gene5292GenBank387022GeneCardsPIM1
Pharmacology
IUPHAR/GtoPdb2158KEGGhsa:5292
Structure
PDB1XQZPDB1XR1PDB1XWS
Drugs

What you can answer from here — as of September 07, 2019

28DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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84+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein kinase pim-1, how selective are they, and which programs against it are still in active trials?

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