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Befotertinib

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

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Identification

Generic Name
Befotertinib
DrugBank Accession Number
DB18844
Background

Befotertinib is under investigation in clinical trial NCT05007938 (Befotertinib and Icotinib in Treatment-naive Patients With Advanced Egfr-mutant Lung Cancer).

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 567.617
Monoisotopic: 567.256957787
Chemical Formula
C29H32F3N7O2
Synonyms
  • 2-propenamide, n-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1h-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-
  • N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)prop-2-enamide
External IDs
  • D-0316
  • D0316
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available
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Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
0XT2CPR891
CAS number
1835667-63-4
InChI Key
USOCZVZOXKTJTI-UHFFFAOYSA-N
InChI
InChI=1S/C29H32F3N7O2/c1-6-27(40)34-22-15-23(26(41-5)16-25(22)38(4)14-13-37(2)3)36-28-33-12-11-21(35-28)20-17-39(18-29(30,31)32)24-10-8-7-9-19(20)24/h6-12,15-17H,1,13-14,18H2,2-5H3,(H,34,40)(H,33,35,36)
IUPAC Name
SMILES
COC1=CC(N(C)CCN(C)C)=C(NC(=O)C=C)C=C1NC1=NC=CC(=N1)C1=CN(CC(F)(F)F)C2=CC=CC=C12

References

General References
Not Available
ChemSpider
115006925
ChEMBL
CHEMBL5095167

Clinical Trials

Clinical Trials
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PhaseStatusPurposeConditionsCountStart DateWhy Stopped100+ additional columns
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4RecruitingTreatment3-year Disease-free Survival1somestatusstop reasonjust information to hide
2Active Not RecruitingTreatmentNon-Small Cell Lung Cancer (NSCLC)1somestatusstop reasonjust information to hide
2CompletedTreatmentEGFR T790M / Non-Small Cell Lung Cancer (NSCLC) / Solid Tumors1somestatusstop reasonjust information to hide
2RecruitingTreatmentEGFR G719X / EGFR L861Q / EGFR S768I / Metastatic Non-Small Cell Lung Cancer1somestatusstop reasonjust information to hide
2, 3Active Not RecruitingTreatmentEGFR Gene Mutations / Non-Small Cell Lung Cancer (NSCLC)1somestatusstop reasonjust information to hide

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at June 26, 2024 18:30 / Updated at June 27, 2024 01:29