Chemotherapy-Induced Nausea and Vomiting (CINV)

Also known as: Nausea and Vomiting Chemotherapy-Induced / Nausea Post Chemotherapy / Nausea and Vomiting, Chemotherapy-Induced / Vomiting post chemotherapy / Chemotherapy-Induced Nausea and Vomiting / Chemotherapy Induced Nausea and Vomiting / Chemotherapy-induced nausea and vomiting (disorder) / Chemotherapy sickness (disorder) / Nausea / Nausea NOS (finding) / Nausea NOS / Nausea (finding) / [D]Nausea (context-dependent category) / Queasy / Finding of nausea (finding) / Feeling queasy / Nauseated / Nauseous / [D]Nausea / Vomiting (disorder) / Vomiting / (Vomiting (& [C/O] or [symptoms])) or (rumination) / (Vomiting) or (bilious attack) or (throwing up) / Vomiting NOS / Vomiting NOS (disorder) / [D]Emesis (context-dependent category) / [D]Emesis / Vomited / Emesis / Vomiting disorder / Vomiting symptoms (disorder) / [D]Vomiting / [D]Vomiting (context-dependent category) / Finding of vomiting (finding)

DrugDrug NameDrug Description
DB00757DolasetronAn antinauseant and antiemetic used in chemotherapy and postoperatively.
DB00470DronabinolA synthetic delta-9-THC used in the treatment of anorexia and weight loss in HIV patients as well as nausea and vomiting in cancer chemotherapy.
DB00186LorazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
DB01233MetoclopramideAn antiemetic agent and dopamine D2 antagonist used in the treatment of gastroesophageal reflux disease, prevention of nausea and vomiting, and to stimulate gastric emptying.
DB00904OndansetronA serotonin 5-HT3 receptor antagonist used to prevent nausea and vomiting in cancer chemotherapy and postoperatively.
DB00377PalonosetronA serotonin antagonist used in the prophylaxis or management of vomiting that results from emetogenic chemotherapy, and for the management of postoperative nausea and vomiting.
DB11699TropisetronA 5HT-3 receptor antagonist used as an antiemetic in the treatment of chemotherapy-induced nausea and vomiting.
DrugDrug NameTargetType
DB00757Dolasetron5-hydroxytryptamine receptor 3Atarget
DB00757DolasetronCytochrome P450 3A4enzyme
DB00757DolasetronCytochrome P450 2D6enzyme
DB00757DolasetronCytochrome P450 2C9enzyme
DB00470DronabinolCannabinoid receptor 1target
DB00470DronabinolCytochrome P450 3A4enzyme
DB00470DronabinolCytochrome P450 2C9enzyme
DB00470DronabinolCannabinoid receptor 2target
DB00470DronabinolP-glycoprotein 1transporter
DB00470DronabinolATP-binding cassette sub-family G member 2transporter
DB00470DronabinolProstaglandin G/H synthase 1enzyme
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA(A) Receptortarget
DB00186LorazepamCytochrome P450 3A4enzyme
DB00186LorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB01233MetoclopramideMuscarinic acetylcholine receptor M1target
DB01233MetoclopramideDopamine D2 receptortarget
DB01233MetoclopramideCytochrome P450 2D6enzyme
DB01233Metoclopramide5-hydroxytryptamine receptor 4target
DB01233Metoclopramide5-hydroxytryptamine receptor 3Atarget
DB01233MetoclopramideCytochrome P450 3A4enzyme
DB01233MetoclopramideCytochrome P450 1A2enzyme
DB01233MetoclopramideP-glycoprotein 1transporter
DB01233MetoclopramideAlpha-1-acid glycoprotein 1carrier
DB00904Ondansetron5-hydroxytryptamine receptor 3Atarget
DB00904OndansetronCytochrome P450 3A4enzyme
DB00904OndansetronCytochrome P450 1A2enzyme
DB00904OndansetronCytochrome P450 2D6enzyme
DB00904OndansetronCytochrome P450 3A5enzyme
DB00904OndansetronCytochrome P450 3A7enzyme
DB00904Ondansetron5-hydroxytryptamine receptor 4target
DB00904Ondansetron5-hydroxytryptamine receptor 1Atarget
DB00904Ondansetron5-hydroxytryptamine receptor 1Btarget
DB00904OndansetronMu-type opioid receptortarget
DB00904OndansetronCytochrome P450 2C9enzyme
DB00904OndansetronCytochrome P450 2E1enzyme
DB00377Palonosetron5-hydroxytryptamine receptor 3Atarget
DB00377PalonosetronCytochrome P450 2D6enzyme
DB00377PalonosetronCytochrome P450 3A4enzyme
DB00377PalonosetronCytochrome P450 1A2enzyme
DB11699Tropisetron5-hydroxytryptamine receptor 3Atarget
DrugDrug NamePhaseStatusCount
DB00673Aprepitant1Completed4
DB00673Aprepitant1Terminated1
DB06634Casopitant1Completed7
DB06634Casopitant1Terminated1
DB00531Cyclophosphamide1Terminated1
DB01234Dexamethasone1Completed2
DB01234Dexamethasone1Terminated1
DB00390Digoxin1Completed1
DB01248Docetaxel1Completed1
DB00757Dolasetron1Completed1
DB06717Fosaprepitant1Completed3
DB06717Fosaprepitant1Terminated1
DB00889Granisetron1Completed2
DB00889Granisetron1Withdrawn2
DB01026Ketoconazole1Completed2
DB00683Midazolam1Completed1
DB00218Moxifloxacin1Completed1
DB00904Ondansetron1Completed5
DB00904Ondansetron1Terminated1
DB01045Rifampicin1Completed1
DB09291Rolapitant1Completed3
DB00412Rosiglitazone1Completed1
DB00795Sulfasalazine1Completed1
DB00682Warfarin1Completed1
DB00673Aprepitant2Completed4
DB00673Aprepitant2Recruiting1
DB00673Aprepitant2Terminated1
DB00673Aprepitant2Unknown Status3
DB06774Capsaicin2Recruiting1
DB00564Carbamazepine2Unknown Status1
DB06634Casopitant2Completed1
DB01234Dexamethasone2Completed6
DB01234Dexamethasone2Recruiting2
DB01234Dexamethasone2Unknown Status2
DB06717Fosaprepitant2Completed2
DB06717Fosaprepitant2Recruiting1
DB06717Fosaprepitant2Terminated1
DB00889Granisetron2Completed2
DB00889Granisetron2Not Yet Recruiting1
DB00889Granisetron2Withdrawn1
DB00351Megestrol acetate2Recruiting1
DB09048Netupitant2Completed2
DB09048Netupitant2Recruiting1
DB00334Olanzapine2Completed2
DB00334Olanzapine2Recruiting1
DB00334Olanzapine2Unknown Status1
DB00904Ondansetron2Completed5
DB00904Ondansetron2Recruiting1
DB00904Ondansetron2Unknown Status1
DB00377Palonosetron2Completed6
DB00377Palonosetron2Unknown Status2
DB00213Pantoprazole2Recruiting1
DB09290Ramosetron2Completed1
DB08839Serotonin2Completed1
DB01234Dexamethasone2 / 3Recruiting1
DB09048Netupitant2 / 3Recruiting1
DB00377Palonosetron2 / 3Recruiting1
DB00673Aprepitant3Completed12
DB00673Aprepitant3Not Yet Recruiting1
DB00673Aprepitant3Terminated1
DB00673Aprepitant3Unknown Status1
DB06634Casopitant3Completed3
DB06634Casopitant3Withdrawn1
DB01234Dexamethasone3Active Not Recruiting1
DB01234Dexamethasone3Completed22
DB01234Dexamethasone3Not Yet Recruiting1
DB01234Dexamethasone3Recruiting1
DB01234Dexamethasone3Terminated1
DB01234Dexamethasone3Unknown Status1
DB01234Dexamethasone3Withdrawn1
DB00470Dronabinol3Completed2
DB00470Dronabinol3Recruiting1
DB09378Fluprednisolone3Recruiting1
DB06717Fosaprepitant3Completed4
DB06717Fosaprepitant3Not Yet Recruiting1
DB06717Fosaprepitant3Terminated1
DB14019Fosnetupitant3Completed1
DB00889Granisetron3Completed8
DB00889Granisetron3Not Yet Recruiting1
DB09048Netupitant3Active Not Recruiting1
DB09048Netupitant3Completed4
DB11062Octisalate3Withdrawn1
DB09535Octocrylene3Withdrawn1
DB00334Olanzapine3Completed3
DB00334Olanzapine3Recruiting2
DB00904Ondansetron3Completed11
DB00904Ondansetron3Terminated1
DB00904Ondansetron3Withdrawn1
DB00377Palonosetron3Active Not Recruiting1
DB00377Palonosetron3Completed11
DB00377Palonosetron3Not Yet Recruiting1
DB00377Palonosetron3Unknown Status1
DB09291Rolapitant3Completed3
DB09536Titanium dioxide3Completed1
DB11699Tropisetron3Completed1
DB09321Zinc oxide3Completed1
DB09321Zinc oxide3Withdrawn1
DB00673Aprepitant4Completed1
DB01234Dexamethasone4Completed1
DB01234Dexamethasone4Recruiting2
DB00757Dolasetron4Recruiting1
DB06717Fosaprepitant4Completed1
DB00889Granisetron4Recruiting2
DB09048Netupitant4Recruiting1
DB00334Olanzapine4Recruiting1
DB00904Ondansetron4Recruiting2
DB00377Palonosetron4Completed1
DB00377Palonosetron4Recruiting1
DB11699Tropisetron4Recruiting1
DB00673AprepitantNot AvailableCompleted2
DB00673AprepitantNot AvailableNot Yet Recruiting1
DB09110Coenzyme MNot AvailableCompleted1
DB01234DexamethasoneNot AvailableCompleted1
DB01234DexamethasoneNot AvailableNot Yet Recruiting1
DB01234DexamethasoneNot AvailableRecruiting1
DB01234DexamethasoneNot AvailableUnknown Status1
DB00997DoxorubicinNot AvailableCompleted1
DB06717FosaprepitantNot AvailableCompleted2
DB06717FosaprepitantNot AvailableNot Yet Recruiting1
DB00889GranisetronNot AvailableNot Yet Recruiting1
DB01181IfosfamideNot AvailableCompleted1
DB09048NetupitantNot AvailableCompleted1
DB00334OlanzapineNot AvailableUnknown Status1
DB00377PalonosetronNot AvailableCompleted1
DB00377PalonosetronNot AvailableRecruiting1
DB00377PalonosetronNot AvailableUnknown Status1
DB09290RamosetronNot AvailableUnknown Status1
DB01041ThalidomideNot AvailableRecruiting1
DB11699TropisetronNot AvailableUnknown Status1
DB00541VincristineNot AvailableCompleted1