Kidney Transplant Rejection

Also known as: Kidney transplant rejection / Renal Transplant Rejection / Acute allograft nephropathy

DrugDrug NameDrug Description
DB00087AlemtuzumabA monoclonal anti-CD52 antibody used in the treatment of B-cell chronic lymphocytic leukemia and relapsing forms of multiple sclerosis.
DB09312Antilymphocyte immunoglobulin (horse)A primarily IgG immune globulin used to manage allograft rejection in renal transplant patients.
DB00098Antithymocyte immunoglobulin (rabbit)A purified form of rabbit anti-thymocyte antibodies used for immunosuppression in patients receiving kidney transplants.
DB00993AzathioprineAn immunosuppressant used to prevent renal transplant rejection, treat rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
DB00074BasiliximabA monoclonal anti-C25 antibody (interleukin-2 receptor alpha subunit) used as immunosuppressive therapy in kidney transplant patients.
DB06681BelataceptA selective T-cell costimulation blocker used in the prophylaxis of organ rejection in adult patients receiving a kidney transplant.
DB00091CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DB01590EverolimusA mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.
DB00075MuromonabA monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.
DB00688Mycophenolate mofetilAn inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants.
DB01024Mycophenolic acidAn immunosuppressant used to prevent organ transplant rejections.
DB00864TacrolimusA calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
DrugDrug NameTargetType
DB00087AlemtuzumabCAMPATH-1 antigentarget
DB00087AlemtuzumabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00087AlemtuzumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00087AlemtuzumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB00087AlemtuzumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00087AlemtuzumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00087AlemtuzumabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB00098Antithymocyte immunoglobulin (rabbit)T-cell surface glycoprotein CD1atarget
DB00098Antithymocyte immunoglobulin (rabbit)Major histocompatibility complex class I-related gene proteintarget
DB00098Antithymocyte immunoglobulin (rabbit)Integrin alpha-Ltarget
DB00098Antithymocyte immunoglobulin (rabbit)T-lymphocyte activation antigen CD86target
DB00098Antithymocyte immunoglobulin (rabbit)Low affinity immunoglobulin gamma Fc region receptor II-btarget
DB00098Antithymocyte immunoglobulin (rabbit)T-cell surface glycoprotein CD4target
DB00098Antithymocyte immunoglobulin (rabbit)Integrin beta-1target
DB00098Antithymocyte immunoglobulin (rabbit)Integrin alpha-Vtarget
DB00098Antithymocyte immunoglobulin (rabbit)Integrin beta-3target
DB00993AzathioprineThiopurine S-methyltransferaseenzyme
DB00993AzathioprineXanthine dehydrogenase/oxidaseenzyme
DB00993AzathioprineGlutathione S-transferase A1enzyme
DB00993AzathioprineGlutathione S-transferase A2enzyme
DB00993AzathioprineGlutathione S-transferase Mu 1enzyme
DB00993AzathioprineRas-related C3 botulinum toxin substrate 1target
DB00993AzathioprineCytochrome P450 1A2enzyme
DB00993AzathioprineHypoxanthine-guanine phosphoribosyltransferaseenzyme
DB00993AzathioprineNucleotide triphosphate diphosphatase NUDT15enzyme
DB00993AzathioprineEquilibrative nucleoside transporter 2transporter
DB00993AzathioprineSolute carrier family 28 member 3transporter
DB00993AzathioprineP-glycoprotein 1transporter
DB00993AzathioprineSolute carrier family 43 member 3transporter
DB00993AzathioprineSerum albumincarrier
DB00993AzathioprineInosine-5'-monophosphate dehydrogenase 1enzyme
DB00993AzathioprineInosine-5'-monophosphate dehydrogenase 2enzyme
DB00993AzathioprineGMP synthase [glutamine-hydrolyzing]enzyme
DB00993AzathioprineInosine triphosphate pyrophosphataseenzyme
DB00074BasiliximabInterleukin-2 receptor subunit alphatarget
DB00074BasiliximabInterleukin-2 receptor subunit betatarget
DB06681BelataceptT-lymphocyte activation antigen CD86target
DB06681BelataceptT-lymphocyte activation antigen CD80target
DB00091CyclosporineCalcium signal-modulating cyclophilin ligandtarget
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
DB00091CyclosporineCalcineurin subunit B type 2target
DB00091CyclosporineCytochrome P450 3A5enzyme
DB00091CyclosporineCytochrome P450 3A4enzyme
DB00091CyclosporineP-glycoprotein 1transporter
DB00091CyclosporineBile salt export pumptransporter
DB00091CyclosporineIleal sodium/bile acid cotransportertransporter
DB00091CyclosporineSodium/bile acid cotransportertransporter
DB00091CyclosporineSolute carrier family 22 member 6transporter
DB00091CyclosporineMultidrug resistance-associated protein 7transporter
DB00091CyclosporineCanalicular multispecific organic anion transporter 1transporter
DB00091CyclosporineATP-binding cassette sub-family G member 2transporter
DB00091CyclosporineSolute carrier organic anion transporter family member 1B1transporter
DB00091CyclosporineCytochrome P450 2C19enzyme
DB00091CyclosporineCytochrome P450 2D6enzyme
DB00091CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
DB00091CyclosporineSolute carrier organic anion transporter family member 1B3transporter
DB01590EverolimusSerine/threonine-protein kinase mTORtarget
DB01590EverolimusCytochrome P450 3A4enzyme
DB01590EverolimusSolute carrier organic anion transporter family member 1B1transporter
DB01590EverolimusSolute carrier organic anion transporter family member 1B3transporter
DB01590EverolimusSolute carrier organic anion transporter family member 1A2transporter
DB01590EverolimusCytochrome P450 2D6enzyme
DB01590EverolimusP-glycoprotein 1transporter
DB00075MuromonabT-cell surface glycoprotein CD3 epsilon chaintarget
DB00075MuromonabLow affinity immunoglobulin gamma Fc region receptor III-Btarget
DB00075MuromonabT-cell surface glycoprotein CD3 delta chaintarget
DB00075MuromonabT-cell surface glycoprotein CD3 gamma chaintarget
DB00075MuromonabT-cell surface glycoprotein CD3 zeta chaintarget
DB00688Mycophenolate mofetilInosine-5'-monophosphate dehydrogenase 2target
DB00688Mycophenolate mofetilInosine-5'-monophosphate dehydrogenase 1target
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-1enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-7enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-6enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-9enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 2B7enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-8enzyme
DB00688Mycophenolate mofetilUDP-glucuronosyltransferase 1-10enzyme
DB00688Mycophenolate mofetilLiver carboxylesterase 1enzyme
DB00688Mycophenolate mofetilCytochrome P450 3A4enzyme
DB00688Mycophenolate mofetilCytochrome P450 3A5enzyme
DB00688Mycophenolate mofetilCytochrome P450 2C8enzyme
DB00688Mycophenolate mofetilSolute carrier organic anion transporter family member 1B1transporter
DB00688Mycophenolate mofetilSolute carrier organic anion transporter family member 1B3transporter
DB00688Mycophenolate mofetilATP-binding cassette sub-family G member 2transporter
DB00688Mycophenolate mofetilP-glycoprotein 1transporter
DB00688Mycophenolate mofetil6-pyruvoyl tetrahydrobiopterin synthasetarget
DB00688Mycophenolate mofetilCarboxylic ester hydrolaseenzyme
DB00688Mycophenolate mofetilCanalicular multispecific organic anion transporter 1transporter
DB01024Mycophenolic acidInosine-5'-monophosphate dehydrogenase 2target
DB01024Mycophenolic acidInosine-5'-monophosphate dehydrogenase 1target
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-1enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-9enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 2B7enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-7enzyme
DB01024Mycophenolic acidUDP-glucuronosyltransferase 1-6enzyme
DB00864TacrolimusPeptidyl-prolyl cis-trans isomerase FKBP1Atarget
DB00864TacrolimusCytochrome P450 3A4enzyme
DB00864TacrolimusCytochrome P450 3A5enzyme
DB00864TacrolimusP-glycoprotein 1transporter
DB00864TacrolimusATP-binding cassette sub-family A member 5transporter
DB00864TacrolimusSerum albumincarrier
DB00864TacrolimusAlpha-1-acid glycoprotein 1carrier
DB00864TacrolimusSolute carrier organic anion transporter family member 1B1transporter
DrugDrug NamePhaseStatusCount
DB00864Tacrolimus0Enrolling by Invitation1
DB00864Tacrolimus0Terminated1
DB15726Human Umbilical Cord Mesenchymal Stem Cells1Recruiting1
DB15726Human Umbilical Cord Mesenchymal Stem Cells1Unknown Status1
DB08879Belimumab1 / 2Completed1
DB00188Bortezomib1 / 2Completed1
DB12849Clazakizumab1 / 2Active Not Recruiting1
DB09331Daratumumab1 / 2Recruiting1
DB12010Fostamatinib1 / 2Recruiting1
DB00073Rituximab1 / 2Completed1
DB00135Tyrosine1 / 2Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)2Recruiting1
DB01590Everolimus2Active Not Recruiting1
DB15726Human Umbilical Cord Mesenchymal Stem Cells2Active Not Recruiting1
DB15258Imlifidase2Recruiting1
DB00065Infliximab2Recruiting1
DB12821Perflubutane2Recruiting1
DB00860Prednisolone2Recruiting1
DB00864Tacrolimus2Recruiting2
DB00098Antithymocyte immunoglobulin (rabbit)3Terminated1
DB00028Human immunoglobulin G3Recruiting1
DB00959Methylprednisolone3Recruiting1
DB00073Rituximab3Recruiting1
DB09153Sodium chloride3Recruiting1
DB00098Antithymocyte immunoglobulin (rabbit)4Completed2
DB00098Antithymocyte immunoglobulin (rabbit)4Recruiting1
DB00074Basiliximab4Completed2
DB00074Basiliximab4Recruiting1
DB06681Belatacept4Active Not Recruiting1
DB06681Belatacept4Recruiting1
DB11799Bictegravir4Not Yet Recruiting1
DB00091Cyclosporine4Terminated1
DB00879Emtricitabine4Not Yet Recruiting1
DB01590Everolimus4Completed1
DB01590Everolimus4Recruiting1
DB01590Everolimus4Terminated1
DB01590Everolimus4Unknown Status1
DB00688Mycophenolate mofetil4Terminated1
DB01024Mycophenolic acid4Completed2
DB01024Mycophenolic acid4Recruiting1
DB01024Mycophenolic acid4Terminated1
DB01024Mycophenolic acid4Unknown Status1
DB00635Prednisone4Completed1
DB00635Prednisone4Recruiting1
DB00635Prednisone4Unknown Status1
DB00877Sirolimus4Completed1
DB00864Tacrolimus4Active Not Recruiting1
DB00864Tacrolimus4Completed2
DB00864Tacrolimus4Recruiting2
DB00864Tacrolimus4Terminated1
DB09299Tenofovir alafenamide4Not Yet Recruiting1
DB06215FerumoxytolNot AvailableCompleted1
DB00073RituximabNot AvailableCompleted1