Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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Displaying entries 4751 - 4775 of 6330 in total

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
							Clear
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*1K	Not Available	-739T>G (rs12720461) -729C>T (rs762551) -163C>A	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*3	Not Available	2116G>A (rs56276455) 5347T>C	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*4	Not Available	2499A>T (rs72547516)	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*7	Not Available	3533G>A (rs56107638)	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*8	Not Available	5166G>A (rs72547517) 5347T>C	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*11	Not Available	558C>A (rs72547513)	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*15	Not Available	125C>G (rs72547511) 5347T>C	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Propafenone	Cytochrome P450 1A2 Gene symbol: CYP1A2 UniProt: P05177	CYP1A2*16	Not Available	2473G>A (rs72547515) 5347T>C	ADR Inferred	Poor drug metabolizer, increased exposure may lead to cardiac arrhythmias and exaggerated beta-adrenergic blocking activity.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2A	Not Available	681G>A (rs4244285)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2B	Not Available	681G>A (rs4244285)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*4	Not Available	1A>G (rs28399504)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*5	Not Available	1297C>T (rs56337013)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*6	Not Available	395G>A (rs72552267)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*7	Not Available	19294T>A (rs72558186)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*22	Not Available	557G>C (rs140278421) 991A>G	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*24	Not Available	99C>T (rs17885098) 991A>G (rs3758581) 1004G>A (rs118203757) show all 4 …	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Escitalopram	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*35	Not Available	12662A>G (rs12769205)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2A	Not Available	681G>A (rs4244285)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2B	Not Available	681G>A (rs4244285)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*4	Not Available	1A>G (rs28399504)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*5	Not Available	1297C>T (rs56337013)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*6	Not Available	395G>A (rs72552267)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*7	Not Available	19294T>A (rs72558186)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*22	Not Available	557G>C (rs140278421) 991A>G	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Sertraline	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*24	Not Available	99C>T (rs17885098) 991A>G (rs3758581) 1004G>A (rs118203757) show all 4 …	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details

Displaying entries 4751 - 4775 of 6330 in total

Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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