Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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Displaying entries 4826 - 4850 of 6330 in total

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
							Clear
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*68B	Not Available	Similar but not identical switch region compared to CYP2D668A. Found in tandem arrangement with CYP2D64.	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*69	Not Available	2988G>A (rs28371725) -1426C>T -1235A>G show all 17 …	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*92	Not Available	1995delC	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*100	Not Available	-1426C>T -1235A>G -1109C>T show all 15 …	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*101	Not Available	-1426C>T -1235A>G -1000G>A show all 14 …	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2A	Not Available	681G>A (rs4244285)	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2B	Not Available	681G>A (rs4244285)	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*4	Not Available	1A>G (rs28399504)	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*5	Not Available	1297C>T (rs56337013)	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*6	Not Available	395G>A (rs72552267)	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*7	Not Available	19294T>A (rs72558186)	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*22	Not Available	557G>C (rs140278421) 991A>G	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*24	Not Available	99C>T (rs17885098) 991A>G (rs3758581) 1004G>A (rs118203757) show all 4 …	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*35	Not Available	12662A>G (rs12769205)	ADR Inferred	Poor drug metabolizer, increased risk for adverse cardiovascular events and lower efficacy. Alternative recommended.	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2A	Not Available	681G>A (rs4244285)	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2B	Not Available	681G>A (rs4244285)	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*4	Not Available	1A>G (rs28399504)	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*5	Not Available	1297C>T (rs56337013)	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*6	Not Available	395G>A (rs72552267)	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*7	Not Available	19294T>A (rs72558186)	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*22	Not Available	557G>C (rs140278421) 991A>G	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*24	Not Available	99C>T (rs17885098) 991A>G (rs3758581) 1004G>A (rs118203757) show all 4 …	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*35	Not Available	12662A>G (rs12769205)	ADR Inferred	Poor drug metabolizer, may lead to hepatotoxicity, visual disturbances, visual hallucinations, and other neurologic disorders	Details
Amitriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*7	Not Available	2935A>C (rs5030867)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details
Amitriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*8	Not Available	1758G>T (rs5030865)	Effect Inferred	Poor drug metabolizer. For individual with two non-functional alleles, alternative drug or dose reduction recommended.	Details

Displaying entries 4826 - 4850 of 6330 in total

Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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