Major prion protein


Major prion protein
  • ASCR
  • PRIP
  • PRP
  • PrP27-30
  • PrP33-35C
Gene Name
Amino acid sequence
>lcl|BSEQ0002199|Major prion protein
Number of residues
Molecular Weight
Theoretical pI
GO Classification
copper ion binding / identical protein binding / microtubule binding / tubulin binding
axon guidance / cell cycle arrest / cellular copper ion homeostasis / cellular response to copper ion / cellular response to drug / learning or memory / metabolic process / negative regulation of activated T cell proliferation / negative regulation of apoptotic process / negative regulation of calcineurin-NFAT signaling cascade / negative regulation of interferon-gamma production / negative regulation of interleukin-17 production / negative regulation of interleukin-2 production / negative regulation of protein phosphorylation / negative regulation of sequence-specific DNA binding transcription factor activity / negative regulation of T cell receptor signaling pathway / protein homooligomerization / regulation of potassium ion transmembrane transport / regulation of protein localization / response to cadmium ion / response to oxidative stress
anchored component of membrane / cell surface / cytoplasm / endoplasmic reticulum / extracellular exosome / extrinsic component of membrane / Golgi apparatus / membrane raft / nucleus / plasma membrane
General Function
Tubulin binding
Specific Function
Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (PubMed:12732622, PubMed:19936054, PubMed:20564047). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0019060|Major prion protein (PRNP)
Chromosome Location
External Identifiers
UniProtKB IDP04156
UniProtKB Entry NamePRIO_HUMAN
GenBank Protein ID190468
GenBank Gene IDM13899
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00759Tetracyclineapproved, vet_approved, withdrawnunknowninhibitorDetails
DB09130Copperapproved, investigationalunknowncofactorDetails