The DNA sequence and comparative analysis of human chromosome 20.

Article Details

Citation

Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J

The DNA sequence and comparative analysis of human chromosome 20.

Nature. 2001 Dec 20-27;414(6866):865-71.

PubMed ID
11780052 [ View in PubMed
]
Abstract

The finished sequence of human chromosome 20 comprises 59,187,298 base pairs (bp) and represents 99.4% of the euchromatic DNA. A single contig of 26 megabases (Mb) spans the entire short arm, and five contigs separated by gaps totalling 320 kb span the long arm of this metacentric chromosome. An additional 234,339 bp of sequence has been determined within the pericentromeric region of the long arm. We annotated 727 genes and 168 pseudogenes in the sequence. About 64% of these genes have a 5' and a 3' untranslated region and a complete open reading frame. Comparative analysis of the sequence of chromosome 20 to whole-genome shotgun-sequence data of two other vertebrates, the mouse Mus musculus and the puffer fish Tetraodon nigroviridis, provides an independent measure of the efficiency of gene annotation, and indicates that this analysis may account for more than 95% of all coding exons and almost all genes.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Tubulin beta-1 chainQ9H4B7Details
Solute carrier family 12 member 5Q9H2X9Details
Matrix metalloproteinase-9P14780Details
Prostacyclin synthaseQ16647Details
Cysteine desulfurase, mitochondrialQ9Y697Details
Glutathione synthetaseP48637Details
Acetyl-coenzyme A synthetase, cytoplasmicQ9NR19Details
Synaptosomal-associated protein 25P60880Details
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrialO43837Details
Spermine oxidaseQ9NWM0Details
Solute carrier family 13 member 3Q8WWT9Details
Tyrosine-protein phosphatase non-receptor type 1P18031Details
Peptidyl-prolyl cis-trans isomerase FKBP1AP62942Details
Alpha-1D adrenergic receptorP25100Details
Acetyl-coenzyme A synthetase 2-like, mitochondrialQ9NUB1Details
Oxytocin-neurophysin 1P01178Details
Proto-oncogene tyrosine-protein kinase SrcP12931Details
Neuronal acetylcholine receptor subunit alpha-4P43681Details
Potassium voltage-gated channel subfamily KQT member 2O43526Details
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]P35558Details
Histamine H3 receptorQ9Y5N1Details
DNA topoisomerase 1P11387Details
Aurora kinase AO14965Details
Protein-glutamine gamma-glutamyltransferase 2P21980Details
Major prion proteinP04156Details
Bactericidal permeability-increasing proteinP17213Details
ThrombomodulinP07204Details
Endothelial protein C receptorQ9UNN8Details
Tumor necrosis factor receptor superfamily member 5P25942Details
Casein kinase II subunit alphaP68400Details
Protein-glutamine gamma-glutamyltransferase EQ08188Details
Tyrosine-protein kinase HCKP08631Details
AdenosylhomocysteinaseP23526Details
M-phase inducer phosphatase 2P30305Details
Laminin subunit alpha-5O15230Details
Neuroendocrine convertase 2P16519Details
Glycogen phosphorylase, brain formP11216Details
Serine palmitoyltransferase 3Q9NUV7Details
Adenosine deaminaseP00813Details
Protein-glutamine gamma-glutamyltransferase 6O95932Details
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrialQ07973Details
Vesicular inhibitory amino acid transporterQ9H598Details
Nociceptin receptorP41146Details
Growth/differentiation factor 5P43026Details
Lethal(3)malignant brain tumor-like protein 1Q9Y468Details
Ribosome-binding protein 1Q9P2E9Details
Bcl-2-like protein 1Q07817Details
Troponin C, skeletal muscleP02585Details
Solute carrier organic anion transporter family member 4A1Q96BD0Details
Matrix metalloproteinase-24Q9Y5R2Details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortP63092Details
Hydroxyacid oxidase 1Q9UJM8Details
Proteasome subunit alpha type-7O14818Details
Hepatocyte nuclear factor 4-alphaP41235Details
Nuclear receptor coactivator 5Q9HCD5Details
DestrinP60981Details
Inosine triphosphate pyrophosphataseQ9BY32Details
Uridine-cytidine kinase-like 1Q9NWZ5Details
SialoadhesinQ9BZZ2Details
Potassium voltage-gated channel subfamily B member 1Q14721Details
Protein-tyrosine kinase 6Q13882Details
Myosin light chain kinase 2, skeletal/cardiac muscleQ9H1R3Details
Solute carrier family 2, facilitated glucose transporter member 10O95528Details
CCAAT/enhancer-binding protein betaP17676Details
Semenogelin-1P04279Details
Lysosomal protective proteinP10619Details
Eukaryotic translation initiation factor 6P56537Details
14-3-3 protein beta/alphaP31946Details
Alternative prion proteinF7VJQ1Details
Copine-1Q99829Details
Minor histocompatibility antigen H13Q8TCT9Details
Tumor protein D54O43399Details
Proliferating cell nuclear antigenP12004Details
Somatostatin receptor type 4P31391Details
Serine/threonine-protein kinase 35Q8TDR2Details
Serine/threonine-protein kinase PAK 5Q9P286Details
Tyrosine-protein kinase SrmsQ9H3Y6Details
Phospholipid transfer proteinP55058Details
Melanocortin receptor 3P41968Details
Potassium voltage-gated channel subfamily S member 1Q96KK3Details
Potassium voltage-gated channel subfamily G member 1Q9UIX4Details
Solute carrier family 23 member 2Q9UGH3Details
Semenogelin-2Q02383Details
DNA (cytosine-5)-methyltransferase 3BQ9UBC3Details