Periplasmic oligopeptide-binding protein
Details
- Name
- Periplasmic oligopeptide-binding protein
- Synonyms
- Not Available
- Gene Name
- oppA
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Amino acid sequence
>lcl|BSEQ0007323|Periplasmic oligopeptide-binding protein MSNITKKSLIAAGILTALIAASAATAADVPAGVQLADKQTLVRNNGSEVQSLDPHKIEGV PESNVSRDLFEGLLISDVEGHPSPGVAEKWENKDFKVWTFHLRENAKWSDGTPVTAHDFV YSWQRLADPNTASPYASYLQYGHIANIDDIIAGKKPATDLGVKALDDHTFEVTLSEPVPY FYKLLVHPSVSPVPKSAVEKFGDKWTQPANIVTNGAYKLKNWVVNERIVLERNPQYWDNA KTVINQVTYLPISSEVTDVNRYRSGEIDMTYNNMPIELFQKLKKEIPNEVRVDPYLCTYY YEINNQKAPFNDVRVRTALKLALDRDIIVNKVKNQGDLPAYSYTPPYTDGAKLVEPEWFK WSQQKRNEEAKKLLAEAGFTADKPLTFDLLYNTSDLHKKLAIAVASIWKKNLGVNVNLEN QEWKTFLDTRHQGTFDVARAGWCADYNEPTSFLNTMLSDSSNNTAHYKSPAFDKLIADTL KVADDTQRSELYAKAEQQLDKDSAIVPVYYYVNARLVKPWVGGYTGKDPLDNIYVKNLYI IKH
- Number of residues
- 543
- Molecular Weight
- 61291.77
- Theoretical pI
- 6.45
- GO Classification
- Processespeptide transport / protein transport / transmembrane transportComponentsATP-binding cassette (ABC) transporter complex / periplasmic space
- General Function
- Not Available
- Specific Function
- This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.
- Pfam Domain Function
- SBP_bac_5 (PF00496)
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0012662|Periplasmic oligopeptide-binding protein (oppA) ATGTCTAACATCACGAAAAAAAGTTTGATTGCAGCGGGAATACTCACTGCGCTCATCGCC GCCAGCGCCGCGACTGCGGCAGACGTGCCCGCCGGCGTTCAGTTAGCCGACAAGCAAACG TTGGTACGTAATAACGGATCAGAAGTGCAGTCTCTCGACCCGCATAAAATTGAAGGCGTG CCGGAATCGAACGTCAGCCGTGACCTCTTCGAAGGCTTATTAATTAGTGATGTCGAGGGG CATCCTTCACCGGGCGTCGCGGAAAAATGGGAAAATAAAGATTTTAAAGTCTGGACATTC CATCTACGTGAAAATGCGAAATGGTCAGATGGTACGCCCGTCACCGCCCATGATTTCGTT TATAGCTGGCAACGCCTGGCCGATCCTAATACGGCATCGCCGTACGCCAGCTATCTGCAA TACGGTCATATCGCTAATATCGATGACATTATCGCCGGTAAAAAACCCGCCACCGATCTG GGGGTAAAAGCGCTTGATGATCACACCTTTGAAGTGACCTTAAGTGAGCCGGTGCCTTAT TTCTACAAATTGTTGGTCCACCCTTCAGTGTCTCCTGTACCGAAATCAGCGGTCGAAAAA TTTGGCGATAAATGGACGCAACCGGCCAATATTGTCACTAACGGCGCTTATAAGTTAAAA AACTGGGTGGTGAACGAACGTATCGTGCTGGAGCGTAACCCGCAATACTGGGATAACGCC AAAACCGTCATCAATCAGGTAACTTATTTGCCTATCTCTTCGGAGGTGACGGATGTCAAC CGCTACCGCAGCGGCGAGATCGATATGACTTATAACAATATGCCGATCGAATTATTCCAG AAACTGAAGAAAGAGATCCCGAATGAAGTCCGCGTAGACCCTTATTTGTGTACCTATTAT TACGAAATTAATAATCAAAAAGCGCCGTTTAACGATGTCCGCGTGCGTACCGCGCTGAAA CTGGCGTTAGATCGCGACATTATTGTTAATAAGGTTAAAAATCAGGGCGATTTACCCGCT TATAGCTACACGCCGCCGTATACCGATGGCGCAAAACTGGTAGAGCCTGAGTGGTTCAAA TGGTCCCAGCAAAAGCGTAATGAAGAAGCGAAGAAATTGTTGGCTGAAGCCGGCTTTACG GCGGATAAGCCCTTAACATTCGACCTGCTGTATAACACCTCCGATCTGCATAAAAAACTG GCCATTGCCGTGGCGTCTATCTGGAAGAAAAATCTGGGCGTCAATGTGAATCTGGAGAAT CAGGAATGGAAAACCTTCCTGGATACCCGTCATCAGGGCACCTTTGATGTTGCCAGAGCC GGGTGGTGCGCAGATTATAATGAACCGACCTCGTTCCTGAATACCATGTTGTCCGACAGT TCAAATAACACCGCGCATTATAAGAGCCCGGCGTTTGATAAGCTGATTGCCGACACGCTG AAAGTGGCGGACGATACGCAGCGCAGCGAACTCTACGCTAAAGCGGAGCAGCAGTTAGAT AAAGACTCGGCTATTGTGCCGGTGTATTACTACGTTAACGCGCGCCTGGTGAAACCCTGG GTGGGCGGGTATACCGGTAAAGACCCGCTGGATAATATTTATGTGAAAAACTTATATATT ATCAAACATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P06202 UniProtKB Entry Name OPPA_SALTY GenBank Protein ID 47808 GenBank Gene ID X04194 - General References
- Hiles ID, Gallagher MP, Jamieson DJ, Higgins CF: Molecular characterization of the oligopeptide permease of Salmonella typhimurium. J Mol Biol. 1987 May 5;195(1):125-42. [Article]
- Hiles ID, Higgins CF: Peptide uptake by Salmonella typhimurium. The periplasmic oligopeptide-binding protein. Eur J Biochem. 1986 Aug 1;158(3):561-7. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Tame JR, Murshudov GN, Dodson EJ, Neil TK, Dodson GG, Higgins CF, Wilkinson AJ: The structural basis of sequence-independent peptide binding by OppA protein. Science. 1994 Jun 10;264(5165):1578-81. [Article]
- Tame JR, Dodson EJ, Murshudov G, Higgins CF, Wilkinson AJ: The crystal structures of the oligopeptide-binding protein OppA complexed with tripeptide and tetrapeptide ligands. Structure. 1995 Dec 15;3(12):1395-406. [Article]
- Davies TG, Hubbard RE, Tame JR: Relating structure to thermodynamics: the crystal structures and binding affinity of eight OppA-peptide complexes. Protein Sci. 1999 Jul;8(7):1432-44. [Article]
- Sleigh SH, Seavers PR, Wilkinson AJ, Ladbury JE, Tame JR: Crystallographic and calorimetric analysis of peptide binding to OppA protein. J Mol Biol. 1999 Aug 13;291(2):393-415. [Article]