Chemotaxis protein methyltransferase

Details

Name

Chemotaxis protein methyltransferase

Synonyms

• 2.1.1.80

Gene Name

cheR

UniProtKB Entry

P07801Swiss-Prot

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

NCBI Taxonomy ID

99287

Amino acid sequence

>lcl|BSEQ0011805|Chemotaxis protein methyltransferase
MTSSLPSGQTSVLLQMTQRLALSDAHFRRICQLIYQRAGIVLADHKRDMVYNRLVRRLRA
LGLDDFGRYLSMLEANQNSAEWQAFINALTTNLTAFFREAHHFPILAEHARRRHGEYRVW
SAAASTGEEPYSIAITLADALGMAPGRWKVFASDIDTEVLEKARSGIYRLSELKTLSPQQ
LQRYFMRGTGPHEGLVRVRQELANYVEFSSVNLLEKQYNVPGPFDAIFCRNVMIYFDKTT
QEDILRRFVPLLKPDGLLFAGHSENFSNLVREFSLRGQTVYALSKDKA

Number of residues

288

Molecular Weight

32923.325

Theoretical pI

9.6

GO Classification

Functions

protein-glutamate O-methyltransferase activity

Processes

chemotaxis

General Function

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

Specific Function

protein-glutamate O-methyltransferase activity

Pfam Domain Function

• CheR (PF01739)
• CheR_N (PF03705)

Signal Regions

Not Available

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0011806|Chemotaxis protein methyltransferase (cheR)
ATGACATCATCTCTGCCCTCCGGGCAAACGTCAGTATTGTTACAGATGACACAGCGCCTC
GCGCTGTCCGACGCGCATTTTCGTCGGATATGTCAATTAATCTACCAGCGCGCAGGGATC
GTGCTGGCCGACCATAAGCGGGATATGGTTTATAACCGCCTGGTCCGTCGGCTGCGTGCC
CTGGGACTGGATGATTTTGGCCGTTATCTCAGTATGCTGGAGGCTAATCAAAACAGCGCT
GAGTGGCAGGCTTTTATCAACGCTCTGACTACCAACCTGACCGCTTTTTTTCGCGAGGCG
CACCATTTTCCCATCCTTGCGGAACATGCGCGTCGCCGCCACGGCGAGTACCGCGTCTGG
AGTGCGGCGGCATCGACAGGAGAAGAACCTTACAGTATCGCCATTACGCTGGCGGATGCG
TTAGGGATGGCCCCCGGTCGCTGGAAAGTATTCGCCAGCGATATTGATACTGAAGTGCTG
GAAAAAGCGAGAAGCGGTATTTATCGCCTCAGCGAACTGAAAACGTTATCGCCGCAGCAG
CTACAACGTTACTTCATGCGCGGTACGGGGCCGCATGAAGGACTGGTGCGCGTGCGTCAG
GAACTGGCCAATTATGTTGAATTTTCCTCCGTTAATTTATTGGAAAAGCAGTACAACGTA
CCCGGTCCCTTTGACGCGATTTTTTGCCGTAACGTCATGATCTATTTTGATAAAACGACT
CAGGAGGACATTCTGCGCCGTTTTGTTCCACTCCTTAAACCTGACGGACTGTTGTTTGCC
GGTCACTCAGAAAACTTTAGCAACCTCGTGCGCGAGTTTAGCCTGCGCGGACAGACGGTG
TATGCGCTAAGTAAGGATAAAGCATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P07801
UniProtKB Entry Name	CHER_SALTY
GenBank Gene ID	J02757
PDB ID(s)	1AF7, 1BC5
KEGG ID	stm:STM1918
NCBI Gene ID	1253439

General References

1. Simms SA, Stock AM, Stock JB: Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria. J Biol Chem. 1987 Jun 25;262(18):8537-43. [Article]
2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
3. Djordjevic S, Stock AM: Crystal structure of the chemotaxis receptor methyltransferase CheR suggests a conserved structural motif for binding S-adenosylmethionine. Structure. 1997 Apr 15;5(4):545-58. [Article]
4. Djordjevic S, Stock AM: Chemotaxis receptor recognition by protein methyltransferase CheR. Nat Struct Biol. 1998 Jun;5(6):446-50. [Article]

Associated Data

Bio-Entities

Bio-Entity	Type
Chemotaxis protein methyltransferase (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720))	protein primary

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
S-adenosyl-L-homocysteine	experimental	unknown	target		Details