Aspartate carbamoyltransferase catalytic chain

Details

Name
Aspartate carbamoyltransferase catalytic chain
Synonyms
  • 2.1.3.2
  • Aspartate transcarbamylase
  • ATCase
Gene Name
pyrB
UniProtKB Entry
P0A789Swiss-Prot
Organism
Shigella flexneri
NCBI Taxonomy ID
623
Amino acid sequence
>lcl|BSEQ0011387|Aspartate carbamoyltransferase catalytic chain
MANPLYQKHIISINDLSRDDLNLVLATAAKLKANPQPELLKHKVIASCFFEASTRTRLSF
ETSMHRLGASVVGFSDSANTSLGKKGETLADTISVISTYVDAIVMRHPQEGAARLATEFS
GNVPVLNAGDGSNQHPTQTLLDLFTIQETQGRLDNLHVAMVGDLKYGRTVHSLTQALAKF
DGNRFYFIAPDALAMPQYILDMLDEKGIAWSLHSSIEEVMAEVDILYMTRVQKERLDPSE
YANVKAQFVLRASDLHNAKANMKVLHPLPRVDEIATDVDKTPHAWYFQQAGNGIFARQAL
LALVLNRDLVL
Number of residues
311
Molecular Weight
34427.02
Theoretical pI
6.59
GO Classification
Functions
amino acid binding / aspartate carbamoyltransferase activity
Processes
'de novo' pyrimidine nucleobase biosynthetic process / 'de novo' UMP biosynthetic process / cellular amino acid metabolic process
General Function
Aspartate carbamoyltransferase activity
Specific Function
Not Available
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011388|Aspartate carbamoyltransferase catalytic chain (pyrB)
ATGGCTAATCCGCTATATCAGAAACATATCATTTCCATAAACGACCTTAGTCGCGATGAC
CTTAATCTGGTGCTGGCGACAGCGGCGAAACTGAAAGCAAACCCGCAACCAGAGCTGTTG
AAGCACAAAGTCATTGCCAGCTGTTTCTTCGAAGCCTCTACCCGTACCCGCCTCTCTTTC
GAAACTTCCATGCACCGCCTGGGTGCCAGCGTGGTGGGCTTCTCCGACAGCGCCAATACA
TCACTGGGTAAAAAAGGCGAAACGCTGGCCGATACCATTTCGGTTATCAGCACTTACGTC
GATGCGATAGTGATGCGTCATCCGCAGGAAGGTGCGGCACGCCTAGCCACCGAATTTTCT
GGCAATGTACCGGTACTGAATGCCGGTGATGGCTCCAACCAACATCCGACGCAAACCTTG
CTGGACTTATTCACCATTCAGGAAACCCAGGGGCGTCTGGACAATCTCCACGTCGCAATG
GTTGGTGACCTGAAATATGGCCGCACCGTTCACTCCCTGACCCAGGCGCTAGCGAAGTTC
GACGGCAACCGTTTTTACTTTATCGCGCCGGATGCGCTGGCAATGCCGCAATACATTCTG
GATATGCTCGATGAAAAAGGGATCGCCTGGAGTCTGCACAGCTCTATTGAAGAAGTGATG
GCGGAAGTAGACATCCTGTACATGACCCGCGTGCAAAAAGAGCGTCTGGACCCGTCCGAG
TACGCCAACGTGAAAGCGCAGTTTGTTCTTCGCGCCAGCGATCTCCACAACGCCAAAGCC
AATATGAAAGTGCTGCATCCGCTGCCGCGTGTTGATGAGATTGCGACGGATGTGGATAAA
ACGCCTCACGCCTGGTACTTCCAGCAAGCAGGCAACGGGATTTTCGCTCGCCAGGCGTTA
CTGGCACTGGTTCTGAATCGCGATCTGGTACTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A789
UniProtKB Entry NamePYRB_SHIFL
GenBank Protein ID24054763
GenBank Gene IDAE005674
KEGG IDsfl:SF4245
NCBI Gene ID1026558
General References
  1. Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
  2. Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Aspartate carbamoyltransferase catalytic chain (Shigella flexneri)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Sparfosic acidexperimentalunknowntargetDetails