Dihydropteroate synthase type-1


Dihydropteroate synthase type-1
  • DHPS
  • Dihydropteroate pyrophosphorylase type I
  • Dihydropteroate synthase type I
  • sul1
Gene Name
Escherichia coli
Amino acid sequence
>lcl|BSEQ0020788|Dihydropteroate synthase type-1
Number of residues
Molecular Weight
Theoretical pI
Not Available
GO Classification
dihydropteroate synthase activity / metal ion binding
folic acid biosynthetic process / response to antibiotic / tetrahydrofolate biosynthetic process
General Function
Metal ion binding
Specific Function
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (By similarity). It is implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0020789|Dihydropteroate synthase type-1 (sulI)
Chromosome Location
Not Available
Not Available
External Identifiers
UniProtKB IDP0C002
UniProtKB Entry NameDHP1_ECOLX
General References
  1. Sundstrom L, Radstrom P, Swedberg G, Skold O: Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21. Mol Gen Genet. 1988 Aug;213(2-3):191-201. [Article]
  2. Stokes HW, Hall RM: A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integrons. Mol Microbiol. 1989 Dec;3(12):1669-83. [Article]
  3. Guerineau F, Mullineaux P: Nucleotide sequence of the sulfonamide resistance gene from plasmid R46. Nucleic Acids Res. 1989 Jun 12;17(11):4370. [Article]
  4. Parent R, Roy PH: The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat. J Bacteriol. 1992 May;174(9):2891-7. [Article]
  5. Stokes HW, Tomaras C, Parsons Y, Hall RM: The partial 3'-conserved segment duplications in the integrons In6 from pSa and In7 from pDGO100 have a common origin. Plasmid. 1993 Jul;30(1):39-50. [Article]
  6. Valentine CR, Heinrich MJ, Chissoe SL, Roe BA: DNA sequence of direct repeats of the sulI gene of plasmid pSa. Plasmid. 1994 Sep;32(2):222-7. [Article]
  7. Liebert CA, Hall RM, Summers AO: Transposon Tn21, flagship of the floating genome. Microbiol Mol Biol Rev. 1999 Sep;63(3):507-22. [Article]
  8. Naas T, Mikami Y, Imai T, Poirel L, Nordmann P: Characterization of In53, a class 1 plasmid- and composite transposon-located integron of Escherichia coli which carries an unusual array of gene cassettes. J Bacteriol. 2001 Jan;183(1):235-49. [Article]
  9. Doi Y, Shibata N, Shibayama K, Kamachi K, Kurokawa H, Yokoyama K, Yagi T, Arakawa Y: Characterization of a novel plasmid-mediated cephalosporinase (CMY-9) and its genetic environment in an Escherichia coli clinical isolate. Antimicrob Agents Chemother. 2002 Aug;46(8):2427-34. [Article]
  10. Sabate M, Navarro F, Miro E, Campoy S, Mirelis B, Barbe J, Prats G: Novel complex sul1-type integron in Escherichia coli carrying bla(CTX-M-9). Antimicrob Agents Chemother. 2002 Aug;46(8):2656-61. [Article]
  11. Wang M, Tran JH, Jacoby GA, Zhang Y, Wang F, Hooper DC: Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. Antimicrob Agents Chemother. 2003 Jul;47(7):2242-8. [Article]
  12. Dubois V, Arpin C, Quentin C, Texier-Maugein J, Poirel L, Nordmann P: Decreased susceptibility to cefepime in a clinical strain of Escherichia coli related to plasmid- and integron-encoded OXA-30 beta-lactamase. Antimicrob Agents Chemother. 2003 Jul;47(7):2380-1. [Article]
  13. Vourli S, Tzouvelekis LS, Tzelepi E, Lebessi E, Legakis NJ, Miriagou V: Characterization of In111, a class 1 integron that carries the extended-spectrum beta-lactamase gene blaIBC-1. FEMS Microbiol Lett. 2003 Aug 8;225(1):149-53. [Article]
  14. Miriagou V, Tzouvelekis LS, Villa L, Lebessi E, Vatopoulos AC, Carattoli A, Tzelepi E: CMY-13, a novel inducible cephalosporinase encoded by an Escherichia coli plasmid. Antimicrob Agents Chemother. 2004 Aug;48(8):3172-4. [Article]
  15. Mammeri H, Van De Loo M, Poirel L, Martinez-Martinez L, Nordmann P: Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe. Antimicrob Agents Chemother. 2005 Jan;49(1):71-6. [Article]
  16. Jeong JY, Yoon HJ, Kim ES, Lee Y, Choi SH, Kim NJ, Woo JH, Kim YS: Detection of qnr in clinical isolates of Escherichia coli from Korea. Antimicrob Agents Chemother. 2005 Jun;49(6):2522-4. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails