Sodium/potassium-transporting ATPase subunit beta-2
Details
- Name
- Sodium/potassium-transporting ATPase subunit beta-2
- Synonyms
- Adhesion molecule in glia
- AMOG
- Sodium/potassium-dependent ATPase subunit beta-2
- Gene Name
- ATP1B2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0020817|Sodium/potassium-transporting ATPase subunit beta-2 MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMW VMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDS IQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFI KMNRVINFYAGANQSMNVTCAGKRDEDAENLGNFVMFPANGNIDLMYFPYYGKKFHVNYT QPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKLRINKT
- Number of residues
- 290
- Molecular Weight
- 33366.925
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATPase activator activity / ATPase binding / sodiumProcessesATP hydrolysis coupled transmembrane transport / blood coagulation / cell adhesion / cell communication by electrical coupling involved in cardiac conduction / cellular potassium ion homeostasis / cellular sodium ion homeostasis / establishment or maintenance of transmembrane electrochemical gradient / ion transmembrane transport / leukocyte migration / membrane repolarization / positive regulation of ATPase activity / positive regulation of potassium ion import / positive regulation of potassium ion transmembrane transporter activity / positive regulation of sodium ion export from cell / potassium ion import / protein stabilization / sodium ion export from cell / transmembrane transport / transportComponentsapical plasma membrane / cytoplasm / plasma membrane / sodium
- General Function
- Sodium:potassium-exchanging atpase activity
- Specific Function
- This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.
- Pfam Domain Function
- Na_K-ATPase (PF00287)
- Transmembrane Regions
- 40-67
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020818|Sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2) ATGATTCGCCCCAAGACTGAGAACCTTGATGTCATTGTCAATGTCAGTGACACTGAAAGC TGGGACCAGCATGTTCAGAAGCTCAACAAGTTCTTGGAGCCTTACAACGACTCTATCCAA GCCCAAAAGAATGATGTCTGCCGCCCTGGACGCTATTACGAACAGCCAGATAATGGAGTC CTCAACTACCCCAAACGTGCCTGCCAATTCAACCGGACCCAGCTGGGCAACTGCTCCGGC ATTGGGGACTCCACCCACTATGGTTACAGCACTGGGCAGCCCTGTGTCTTCATCAAGATG AACCGGGTCATCAACTTCTATGCAGGAGCAAACCAGAGCATGAATGTTACCTGTGCTGGG AAGCGAGATGAAGATGCTGAGAATCTCGGCAACTTCGTCATGTTCCCCGCCAACGGCAAC ATCGACCTCATGTACTTCCCCTACTATGGCAAAAAGTTCCACGTGAACTACACACAGCCC CTGGTGGCTGTGAAGTTCCTGAATGTGACCCCCAACGTGGAGGTGAATGTAGAATGTCGC ATCAACGCCGCCAACATCGCCACAGACGATGAGCGAGACAAGTTCGCCGGCCGCGTGGCC TTCAAACTCCGCATCAACAAAACCTGA
- Chromosome Location
- 17
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P14415 UniProtKB Entry Name AT1B2_HUMAN HGNC ID HGNC:805 - General References
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- Ruiz A, Bhat SP, Bok D: Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium. Gene. 1996 Oct 17;176(1-2):237-42. [Article]
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- Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R: Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression. J Biol Chem. 1989 Mar 15;264(8):4613-8. [Article]
- Bab-Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk KE, Karlish SJ: A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 2009 Sep 15;48(36):8684-91. doi: 10.1021/bi900868e. [Article]
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