Arylacetamide deacetylase

Details

Name
Arylacetamide deacetylase
Synonyms
  • 3.1.1.3
  • DAC
Gene Name
AADAC
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052614|Arylacetamide deacetylase
MGRKSLYLLIVGILIAYYIYTPLPDNVEEPWRMMWINAHLKTIQNLATFVELLGLHHFMD
SFKVVGSFDEVPPTSDENVTVTETKFNNILVRVYVPKRKSEALRRGLFYIHGGGWCVGSA
ALSGYDLLSRWTADRLDAVVVSTNYRLAPKYHFPIQFEDVYNALRWFLRKKVLAKYGVNP
ERIGISGDSAGGNLAAAVTQQLLDDPDVKIKLKIQSLIYPALQPLDVDLPSYQENSNFLF
LSKSLMVRFWSEYFTTDRSLEKAMLSRQHVPVESSHLFKFVNWSSLLPERFIKGHVYNNP
NYGSSELAKKYPGFLDVRAAPLLADDNKLRGLPLTYVITCQYDLLRDDGLMYVTRLRNTG
VQVTHNHVEDGFHGAFSFLGLKISHRLINQYIEWLKENL
Number of residues
399
Molecular Weight
45733.28
Theoretical pI
Not Available
GO Classification
Functions
catalytic activity / deacetylase activity / hydrolase activity / lipase activity / serine hydrolase activity / triglyceride lipase activity
Processes
positive regulation of triglyceride catabolic process / xenobiotic metabolic process
Components
endoplasmic reticulum membrane / integral component of membrane
General Function
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
Specific Function
Catalytic activity
Pfam Domain Function
Transmembrane Regions
6-23
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0052615|Arylacetamide deacetylase (AADAC)
ATGGGAAGAAAATCGCTGTACCTTCTGATTGTGGGGATCCTCATAGCATATTATATTTAT
ACGCCTCTCCCAGATAACGTTGAGGAGCCATGGAGAATGATGTGGATAAACGCACATCTG
AAAACTATACAAAATTTGGCTACATTTGTGGAGCTCCTGGGACTTCACCATTTTATGGAT
TCCTTTAAGGTTGTCGGGAGCTTTGATGAAGTCCCACCAACCTCAGATGAAAATGTCACT
GTGACTGAGACAAAATTCAACAACATTCTTGTTCGGGTATATGTGCCAAAGAGAAAGTCT
GAAGCACTAAGAAGGGGGTTGTTTTACATCCATGGTGGAGGCTGGTGCGTGGGAAGTGCT
GCTCTAAGTGGTTATGACTTGCTGTCAAGATGGACAGCAGACAGACTTGATGCTGTCGTC
GTATCAACCAACTACAGATTAGCACCTAAGTATCATTTCCCAATTCAATTTGAAGATGTA
TATAATGCCTTAAGGTGGTTCTTACGTAAAAAAGTTCTTGCAAAATATGGTGTGAACCCT
GAGAGAATCGGTATTTCTGGAGATAGTGCAGGAGGGAATTTAGCTGCAGCAGTGACTCAA
CAGCTCCTTGATGACCCAGATGTCAAGATCAAACTCAAGATCCAGTCTTTAATTTATCCT
GCCCTTCAGCCTCTTGATGTAGATTTACCGTCATATCAAGAAAATTCAAATTTTCTATTT
CTATCCAAATCACTCATGGTCAGATTCTGGAGTGAATATTTTACCACTGATAGATCACTT
GAAAAAGCCATGCTTTCCAGACAACATGTACCTGTGGAATCAAGTCATCTCTTCAAATTT
GTTAATTGGAGTTCCCTGCTCCCTGAGAGGTTTATAAAAGGACATGTTTATAACAATCCA
AATTATGGCAGTTCTGAGCTGGCTAAAAAATATCCAGGGTTCCTAGATGTGAGGGCAGCC
CCTTTGTTGGCTGATGACAACAAATTACGTGGCTTACCCCTGACCTATGTCATCACCTGT
CAATATGATCTCTTAAGAGATGATGGACTCATGTATGTCACCCGACTTCGCAACACTGGG
GTTCAGGTGACTCATAACCATGTTGAGGATGGATTCCATGGAGCATTTTCATTTCTGGGA
CTTAAAATTAGTCACAGACTTATAAATCAGTATATTGAGTGGCTAAAGGAAAATCTATAG
Chromosome Location
3
Locus
3q25.1
External Identifiers
ResourceLink
UniProtKB IDP22760
UniProtKB Entry NameAAAD_HUMAN
HGNC IDHGNC:17
General References
  1. Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R: Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. J Biol Chem. 1994 Aug 26;269(34):21650-6. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Probst MR, Jeno P, Meyer UA: Purification and characterization of a human liver arylacetamide deacetylase. Biochem Biophys Res Commun. 1991 May 31;177(1):453-9. doi: 10.1016/0006-291x(91)92005-5. [Article]
  6. Ross MK, Crow JA: Human carboxylesterases and their role in xenobiotic and endobiotic metabolism. J Biochem Mol Toxicol. 2007;21(4):187-96. doi: 10.1002/jbt.20178. [Article]
  7. Watanabe A, Fukami T, Nakajima M, Takamiya M, Aoki Y, Yokoi T: Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis. Drug Metab Dispos. 2009 Jul;37(7):1513-20. doi: 10.1124/dmd.109.026567. Epub 2009 Apr 1. [Article]
  8. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
  9. Kobayashi Y, Fukami T, Nakajima A, Watanabe A, Nakajima M, Yokoi T: Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse. Drug Metab Dispos. 2012 Apr;40(4):671-9. doi: 10.1124/dmd.111.043067. Epub 2011 Dec 29. [Article]
  10. Shimizu M, Fukami T, Kobayashi Y, Takamiya M, Aoki Y, Nakajima M, Yokoi T: A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity. Drug Metab Dispos. 2012 Jun;40(6):1183-90. doi: 10.1124/dmd.112.044883. Epub 2012 Mar 13. [Article]
  11. Muta K, Fukami T, Nakajima M, Yokoi T: N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity. Biochem Pharmacol. 2014 Jan 15;87(2):352-9. doi: 10.1016/j.bcp.2013.10.001. Epub 2013 Oct 11. [Article]
  12. Nourbakhsh M, Douglas DN, Pu CH, Lewis JT, Kawahara T, Lisboa LF, Wei E, Asthana S, Quiroga AD, Law LM, Chen C, Addison WR, Nelson R, Houghton M, Lehner R, Kneteman NM: Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production. J Hepatol. 2013 Aug;59(2):336-43. doi: 10.1016/j.jhep.2013.03.022. Epub 2013 Mar 28. [Article]
  13. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  14. Saito S, Iida A, Sekine A, Kawauchi S, Higuchi S, Ogawa C, Nakamura Y: Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population. J Hum Genet. 2003;48(5):249-70. Epub 2003 Apr 29. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB16349VicagrelinvestigationalunknownsubstrateDetails