dTDP-glucose 4,6-dehydratase
Details
- Name
- dTDP-glucose 4,6-dehydratase
- Synonyms
- 4.2.1.46
- Gene Name
- rfbB
- UniProtKB Entry
- P26391Swiss-Prot
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- NCBI Taxonomy ID
- 99287
- Amino acid sequence
>lcl|BSEQ0011240|dTDP-glucose 4,6-dehydratase MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC DSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSALGE DKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRA WRRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVEDHA RALHMVVTEGKAGETYNIGGHNEKKNLDVVFTICDLLDEIVPKATSYREQITYVADRPGH DRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANTQWVNNVKSGAYQSWIEQNYEGR Q
- Number of residues
- 361
- Molecular Weight
- 40718.29
- Theoretical pI
- 5.74
- GO Classification
- FunctionsdTDP-glucose 4,6-dehydratase activity / NADH bindingProcessesdTDP-rhamnose biosynthetic process / extracellular polysaccharide biosynthetic process / lipopolysaccharide biosynthetic process / O antigen biosynthetic process
- General Function
- Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.
- Specific Function
- dTDP-glucose 4,6-dehydratase activity
- Pfam Domain Function
- GDP_Man_Dehyd (PF16363)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011241|dTDP-glucose 4,6-dehydratase (rfbB) GTGAAGATACTTATTACTGGCGGGGCAGGTTTTATTGGATCAGCTGTTGTCCGCCATATT ATTAAGAATACACAGGACACTGTAGTTAATATTGATAAATTAACCTACGCCGGTAATCTT GAATCCCTTTCTGATATTTCTGAAAGTAATCGCTACAATTTTGAACACGCGGATATTTGT GATTCCGCTGAAATAACGCGTATTTTTGAGCAGTACCAGCCGGACGCGGTGATGCATTTG GCTGCGGAAAGTCATGTGGACCGTTCGATTACCGGGCCAGCAGCATTTATTGAAACCAAT ATCGTCGGCACCTATGCACTTCTTGAAGTTGCGCGTAAATACTGGTCTGCCCTTGGCGAA GATAAAAAAAATAATTTTCGTTTTCATCATATTTCCACTGATGAAGTTTACGGCGATTTA CCGCATCCTGATGAAGTTGAAAACAGCGTTACGCTGCCGTTATTTACTGAAACGACGGCA TATGCGCCAAGTAGCCCCTATTCTGCGTCAAAAGCATCCAGCGATCATTTAGTCCGTGCC TGGCGGCGTACCTATGGTCTACCAACGATCGTTACCAATTGTTCTAATAACTATGGCCCT TATCACTTCCCTGAAAAACTGATTCCGTTGGTCATTTTGAACGCACTGGAAGGAAAGCCT TTGCCAATTTATGGCAAAGGGGATCAGATTCGCGATTGGCTATATGTAGAAGATCATGCT CGCGCGCTTCATATGGTAGTGACTGAAGGCAAGGCAGGGGAGACTTATAACATTGGTGGA CACAATGAGAAGAAAAATCTCGATGTGGTATTTACCATCTGTGATCTGCTGGATGAGATT GTACCCAAAGCGACTTCTTATCGTGAACAAATCACTTATGTCGCGGATCGTCCGGGCCAT GATCGTCGTTATGCCATTGATGCAGGTAAAATTAGCCGCGAATTAGGCTGGAAACCGCTG GAGACCTTTGAAAGCGGTATTCGTAAAACAGTGGAATGGTACCTTGCAAATACTCAATGG GTAAACAATGTTAAAAGTGGGGCGTATCAGAGTTGGATAGAACAGAACTATGAAGGACGC CAGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P26391 UniProtKB Entry Name RMLB_SALTY GenBank Protein ID 581654 GenBank Gene ID X56793 PDB ID(s) 1G1A, 1KEU, 1KEW KEGG ID stm:STM2097 NCBI Gene ID 1253618 - General References
- Jiang XM, Neal B, Santiago F, Lee SJ, Romana LK, Reeves PR: Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2). Mol Microbiol. 1991 Mar;5(3):695-713. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Allard ST, Giraud MF, Whitfield C, Graninger M, Messner P, Naismith JH: The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway. J Mol Biol. 2001 Mar 16;307(1):283-95. [Article]
- Allard ST, Beis K, Giraud MF, Hegeman AD, Gross JW, Wilmouth RC, Whitfield C, Graninger M, Messner P, Allen AG, Maskell DJ, Naismith JH: Toward a structural understanding of the dehydratase mechanism. Structure. 2002 Jan;10(1):81-92. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type dTDP-glucose 4,6-dehydratase (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2'deoxy-Thymidine-5'-Diphospho-Alpha-D-Glucose experimental unknown target Details