dTDP-4-dehydrorhamnose reductase
Details
- Name
- dTDP-4-dehydrorhamnose reductase
- Synonyms
- 1.1.1.133
- dTDP-4-keto-L-rhamnose reductase
- dTDP-6-deoxy-L-lyxo-4-hexulose reductase
- dTDP-6-deoxy-L-mannose dehydrogenase
- dTDP-L-rhamnose synthase
- rmlD
- Gene Name
- rfbD
- UniProtKB Entry
- P26392Swiss-Prot
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- NCBI Taxonomy ID
- 99287
- Amino acid sequence
>lcl|BSEQ0011421|dTDP-4-dehydrorhamnose reductase MNILLFGKTGQVGWELQRSLAPVGNLIALDVHSKEFCGDFSNPKGVAETVRKLRPDVIVN AAAHTAVDKAESEPELAQLLNATSVEAIAKAANETGAWVVHYSTDYVFPGTGDIPWQETD ATSPLNVYGKTKLAGEKALQDNCPKHLIFRTSWVYAGKGNNFAKTMLRLAKERQTLSVIN DQYGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVAGGTTTWHDYAALVFDEARKAGIT LALTELNAVPTSAYPTPASRPGNSRLNTEKFQRNFDLILPQWELGVKRMLTEMFTTTTI
- Number of residues
- 299
- Molecular Weight
- 32553.76
- Theoretical pI
- 6.88
- GO Classification
- FunctionsdTDP-4-dehydrorhamnose reductase activity / metal ion bindingProcessesdTDP-rhamnose biosynthetic process / extracellular polysaccharide biosynthetic process / lipopolysaccharide biosynthetic process / O antigen biosynthetic process
- General Function
- Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS). Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well.
- Specific Function
- dTDP-4-dehydrorhamnose reductase activity
- Pfam Domain Function
- RmlD_sub_bind (PF04321)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011422|dTDP-4-dehydrorhamnose reductase (rfbD) ATGAATATCTTACTTTTTGGTAAGACAGGGCAAGTAGGCTGGGAGTTGCAACGTTCTCTG GCACCGGTAGGGAATCTGATTGCCCTGGATGTCCATTCAAAAGAGTTTTGCGGTGATTTT AGTAATCCGAAAGGCGTTGCCGAAACCGTTCGTAAGCTTCGTCCCGATGTGATTGTTAAC GCAGCAGCCCATACTGCAGTAGATAAAGCAGAGTCTGAACCAGAACTGGCGCAGTTACTT AACGCCACCAGTGTGGAAGCCATCGCTAAAGCAGCCAACGAAACTGGCGCATGGGTAGTG CATTATTCAACCGATTATGTATTTCCTGGTACCGGCGATATCCCATGGCAGGAAACGGAC GCTACGTCGCCGCTGAATGTCTATGGCAAAACCAAACTGGCGGGAGAAAAGGCCCTGCAG GATAACTGCCCTAAACACCTTATCTTCCGCACCAGTTGGGTTTATGCAGGTAAGGGCAAT AATTTCGCAAAGACAATGCTTCGTCTGGCGAAAGAGCGTCAGACACTTTCAGTCATTAAC GATCAGTACGGTGCGCCAACCGGTGCGGAATTACTGGCTGACTGTACGGCGCATGCGATC CGTGTGGCGTTAAATAAACCAGAAGTCGCAGGTCTTTACCATCTGGTTGCCGGGGGAACC ACAACCTGGCATGACTACGCGGCCTTAGTCTTTGACGAGGCGCGCAAAGCAGGGATAACG CTTGCGCTGACTGAGCTTAATGCTGTGCCGACCAGCGCCTACCCGACGCCGGCGAGCAGA CCAGGCAATTCGCGTCTCAATACTGAAAAGTTTCAGCGTAATTTTGACCTTATTCTGCCT CAATGGGAATTAGGAGTTAAGCGTATGCTGACTGAAATGTTTACGACGACAACCATCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P26392 UniProtKB Entry Name RMLD_SALTY GenBank Gene ID X56793 PDB ID(s) 1KBZ, 1KC1, 1KC3, 1N2S KEGG ID stm:STM2096 NCBI Gene ID 1253617 - General References
- Jiang XM, Neal B, Santiago F, Lee SJ, Romana LK, Reeves PR: Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2). Mol Microbiol. 1991 Mar;5(3):695-713. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Blankenfeldt W, Kerr ID, Giraud MF, McMiken HJ, Leonard G, Whitfield C, Messner P, Graninger M, Naismith JH: Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode. Structure. 2002 Jun;10(6):773-86. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type dTDP-4-dehydrorhamnose reductase (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2'-Deoxy-thymidine-beta-L-rhamnose experimental unknown target Details