Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Details
- Name
- Nicotinate-nucleotide pyrophosphorylase [carboxylating]
- Synonyms
- 2.4.2.19
- QAPRTase
- Quinolinate phosphoribosyltransferase [decarboxylating]
- Gene Name
- nadC
- UniProtKB Entry
- P30012Swiss-Prot
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- NCBI Taxonomy ID
- 99287
- Amino acid sequence
>lcl|BSEQ0016392|Nicotinate-nucleotide pyrophosphorylase [carboxylating] MPPRRYNPDDRRDALLERINLDIPAAVAQALREDLGGEVDAGNDITAQLLPADTQAHATV ITREDGVFCGKRWVEEVFIQLAGDDVRLTWHVDDGDAIHANQTVFELNGPARVLLTGERT ALNFVQTLSGVASEVRRYVGLLAGTQTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLT DAFLIKENHIIASGSVRQAVEKAFWLHPDVPVEVEVENLDELDDALKAGADIIMLDNFNT DQMREAVKRVNGQARLEVSGNVTAETLREFAETGVDFISVGALTKHVRALDLSMRFC
- Number of residues
- 297
- Molecular Weight
- 32559.53
- Theoretical pI
- 4.73
- GO Classification
- Functionsnicotinate-nucleotide diphosphorylase (carboxylating) activityProcessesNAD biosynthetic process
- General Function
- Involved in the catabolism of quinolinic acid (QA).
- Specific Function
- nicotinate-nucleotide diphosphorylase (carboxylating) activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016393|Nicotinate-nucleotide pyrophosphorylase [carboxylating] (nadC) ATGCCGCCTCGCCGTTATAACCCAGACGACCGACGTGACGCGCTACTGGAACGCATTAAT CTCGATATCCCTGCCGCCGTTGCTCAGGCGCTGCGTGAAGATTTAGGTGGAGAAGTCGAT GCTGGCAACGATATCACCGCGCAACTTTTGCCGGCAGATACGCAAGCCCATGCCACGGTG ATCACTCGTGAAGACGGCGTTTTCTGCGGCAAGCGCTGGGTTGAAGAGGTCTTCATCCAA CTGGCGGGCGATGATGTGCGCCTCACCTGGCATGTCGATGACGGCGACGCCATTCACGCC AACCAAACAGTGTTTGAACTGAACGGCCCGGCTCGCGTATTGCTGACCGGCGAGCGCACG GCGCTAAACTTTGTCCAGACCCTTTCCGGCGTCGCCAGTGAAGTACGCCGCTACGTTGGA CTGTTGGCTGGCACCCAAACCCAGTTGCTCGACACGCGTAAAACGCTGCCGGGTCTGCGC ACCGCGCTCAAATATGCGGTTTTATGCGGCGGCGGCGCCAATCATCGTCTGGGCCTCACT GACGCGTTCCTGATTAAAGAAAACCATATTATCGCCTCCGGTTCGGTTCGTCAGGCGGTG GAAAAAGCGTTCTGGCTACATCCGGACGTGCCGGTAGAAGTCGAGGTCGAAAATCTGGAT GAACTGGACGATGCGCTGAAAGCAGGCGCGGATATTATCATGCTGGATAATTTCAACACC GACCAGATGCGCGAGGCGGTGAAACGCGTCAACGGCCAGGCGCGGCTGGAAGTATCCGGC AACGTCACCGCGGAAACCTTACGCGAATTTGCTGAAACCGGGGTGGATTTCATCTCCGTT GGCGCGCTGACCAAGCACGTGCGCGCGCTCGATCTCTCCATGCGTTTTTGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P30012 UniProtKB Entry Name NADC_SALTY GenBank Protein ID 415621 GenBank Gene ID L07292 PDB ID(s) 1QAP KEGG ID stm:STM0145 NCBI Gene ID 1251663 - General References
- Hughes KT, Dessen A, Gray JP, Grubmeyer C: The Salmonella typhimurium nadC gene: sequence determination by use of Mud-P22 and purification of quinolinate phosphoribosyltransferase. J Bacteriol. 1993 Jan;175(2):479-86. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Eads JC, Ozturk D, Wexler TB, Grubmeyer C, Sacchettini JC: A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase. Structure. 1997 Jan 15;5(1):47-58. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Quinolinic Acid experimental unknown target Details