Aspartate-semialdehyde dehydrogenase

Details

Name
Aspartate-semialdehyde dehydrogenase
Synonyms
  • 1.2.1.11
  • ASA dehydrogenase
  • Aspartate-beta-semialdehyde dehydrogenase
Gene Name
asd
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Amino acid sequence
>lcl|BSEQ0011199|Aspartate-semialdehyde dehydrogenase
MKNVGFIGWRGMVGSVLMDRMSQENDFENLNPVFFTTSQAGQKAPVFGGKDAGDLKSAFD
IEELKKLDIIVTCQGGDYTNEVYPKLKATGWDGYWVDAASALRMKDDAIIVLDPVNQHVI
SEGLKKGIKTFVGGNCTVSLMLMAIGGLFEKDLVEWISVATYQAASGAGAKNMRELLSQM
GLLEQAVSSELKDPASSILDIERKVTAKMRADNFPTDNFGAALGGSLIPWIDKLLPETGQ
TKEEWKGYAETNKILGLSDNPIPVDGLCVRIGALRCHSQAFTIKLKKDLPLEEIEQIIAS
HNEWVKVIPNDKEITLRELTPAKVTGTLSVPVGRLRKLAMGPEYLAAFTVGDQLLWGAAE
PVRRILKQLVA
Number of residues
371
Molecular Weight
40538.52
Theoretical pI
5.33
GO Classification
Functions
aspartate-semialdehyde dehydrogenase activity / N-acetyl-gamma-glutamyl-phosphate reductase activity / NAD binding / NADP binding
Processes
'de novo' L-methionine biosynthetic process / diaminopimelate biosynthetic process / isoleucine biosynthetic process / lysine biosynthetic process via diaminopimelate / threonine biosynthetic process
Components
cytoplasm
General Function
Nadp binding
Specific Function
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011200|Aspartate-semialdehyde dehydrogenase (asd)
ATGAAAAATGTAGGCTTTATCGGCTGGCGCGGAATGGTGGGTTCCGTATTAATGGATCGT
ATGTCGCAGGAAAATGATTTTGAAAATCTTAATCCCGTATTTTTTACAACTTCACAAGCA
GGTCAAAAAGCACCTGTTTTTGGTGGCAAGGATGCAGGCGACCTGAAAAGTGCATTCGAT
ATTGAAGAACTTAAAAAATTAGACATTATCGTGACTTGCCAAGGTGGCGATTACACCAAT
GAAGTCTATCCAAAATTAAAAGCAACAGGTTGGGATGGTTATTGGGTTGATGCCGCTTCT
GCGTTGCGTATGAAAGATGATGCAATTATCGTGCTTGATCCAGTAAACCAACACGTGATT
TCTGAAGGTTTGAAAAAAGGCATTAAAACTTTCGTGGGCGGTAACTGTACCGTAAGCTTA
ATGTTAATGGCTATCGGCGGTCTATTTGAAAAAGATTTGGTGGAATGGATTTCTGTGGCA
ACTTATCAAGCGGCTTCAGGTGCTGGCGCAAAAAATATGCGTGAATTACTTTCACAAATG
GGTTTATTAGAACAAGCAGTTTCGAGTGAATTAAAAGACCCTGCTTCATCTATTTTAGAT
ATTGAACGTAAAGTGACTGCAAAAATGCGTGCTGATAATTTCCCAACGGATAACTTTGGC
GCGGCATTAGGTGGTAGCTTAATCCCTTGGATTGACAAACTTCTTCCTGAAACAGGGCAA
ACTAAAGAAGAATGGAAAGGTTATGCAGAAACCAATAAAATTTTAGGTTTAAGCGACAAT
CCAATTCCTGTTGATGGTTTATGTGTGCGTATCGGTGCATTACGTTGCCATAGCCAAGCG
TTTACCATCAAACTGAAAAAAGACTTACCATTAGAAGAAATCGAACAAATTATTGCATCA
CATAATGAATGGGTAAAAGTGATTCCAAACGACAAAGAAATCACATTGCGTGAATTAACG
CCAGCGAAAGTAACAGGTACATTAAGCGTGCCAGTGGGGCGTTTACGTAAATTGGCTATG
GGGCCTGAATATTTGGCAGCTTTTACCGTGGGCGACCAATTATTATGGGGTGCGGCAGAG
CCAGTTCGCCGTATTTTAAAACAATTAGTGGCATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP44801
UniProtKB Entry NameDHAS_HAEIN
GenBank Protein ID1573644
GenBank Gene IDL42023
General References
  1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
  2. Moore RA, Bocik WE, Viola RE: Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms. Protein Expr Purif. 2002 Jun;25(1):189-94. [Article]
  3. Blanco J, Moore RA, Viola RE: Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12613-7. Epub 2003 Oct 14. [Article]
  4. Blanco J, Moore RA, Faehnle CR, Coe DM, Viola RE: The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1388-95. Epub 2004 Jul 21. [Article]
  5. Faehnle CR, Blanco J, Viola RE: Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase. Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2320-4. Epub 2004 Nov 26. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03461Nicotinamide adenine dinucleotide phosphateexperimentalunknownDetails
DB03502(4s)-4-{[(2s)-2-Amino-3-Oxopropyl]Sulfanyl}-L-HomoserinateexperimentalunknownDetails
DB04498Aspartate SemialdehydeexperimentalunknownDetails