Sodium/potassium-transporting ATPase subunit beta-3

Details

Name
Sodium/potassium-transporting ATPase subunit beta-3
Synonyms
  • ATPB-3
  • Sodium/potassium-dependent ATPase subunit beta-3
Gene Name
ATP1B3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008794|Sodium/potassium-transporting ATPase subunit beta-3
MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWV
MLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLE
EQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIG
LKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPN
NTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
Number of residues
279
Molecular Weight
31512.34
Theoretical pI
Not Available
GO Classification
Functions
ATPase activator activity / ATPase binding / sodium
Processes
ATP hydrolysis coupled transmembrane transport / blood coagulation / cellular potassium ion homeostasis / cellular sodium ion homeostasis / establishment or maintenance of transmembrane electrochemical gradient / ion transmembrane transport / leukocyte migration / membrane repolarization / positive regulation of ATPase activity / positive regulation of potassium ion import / positive regulation of potassium ion transmembrane transporter activity / positive regulation of sodium ion export from cell / potassium ion import / protein localization to plasma membrane / protein stabilization / sodium ion export from cell / transmembrane transport / transport
Components
caveola / extracellular exosome / melanosome / plasma membrane / sodium
General Function
Sodium:potassium-exchanging atpase activity
Specific Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.
Pfam Domain Function
Transmembrane Regions
36-56
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0017597|Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3)
ATGACGAAGAACGAGAAGAAGTCCCTCAACCAGAGCCTGGCCGAGTGGAAGCTCTTCATC
TACAACCCGACCACCGGAGAATTCCTGGGGCGCACCGCCAAGAGCTGGGGTTTGATCTTG
CTCTTCTACCTAGTTTTTTATGGGTTCCTGGCTGCACTCTTCTCATTCACGATGTGGGTT
ATGCTTCAGACTCTCAACGATGAGGTTCCAAAATACCGTGACCAGATTCCTAGCCCAGGA
CTCATGGTTTTTCCAAAACCAGTGACCGCATTGGAATATACATTCAGTAGGTCTGATCCA
ACTTCGTATGCAGGGTACATTGAAGACCTTAAGAAGTTTCTAAAACCATATACTTTAGAA
GAACAGAAGAACCTCACAGTCTGTCCTGATGGAGCACTTTTTGAACAGAAGGGTCCAGTT
TATGTTGCATGTCAGTTTCCTATTTCATTACTTCAAGCATGCAGTGGTATGAATGATCCT
GATTTTGGCTATTCTCAAGGAAACCCTTGTATTCTTGTGAAAATGAACAGAATAATTGGA
TTAAAGCCTGAAGGAGTGCCAAGGATAGATTGTGTTTCAAAGAATGAAGATATACCAAAT
GTAGCAGTTTATCCTCATAATGGAATGATAGACTTAAAATATTTCCCATATTATGGGAAA
AAACTGCATGTTGGGTATCTACAGCCATTGGTTGCTGTTCAGGTCAGCTTTGCTCCTAAC
AACACTGGGAAAGAAGTAACAGTTGAGTGCAAGATTGATGGATCAGCCAACCTAAAAAGT
CAGGATGATCGTGACAAGTTTTTGGGACGAGTTATGTTCAAAATCACAGCACGTGCATAG
Chromosome Location
3
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP54709
UniProtKB Entry NameAT1B3_HUMAN
HGNC IDHGNC:806
General References
  1. Malik N, Canfield VA, Beckers MC, Gros P, Levenson R: Identification of the mammalian Na,K-ATPase 3 subunit. J Biol Chem. 1996 Sep 13;271(37):22754-8. [Article]
  2. Malik N, Canfield V, Sanchez-Watts G, Watts AG, Scherer S, Beatty BG, Gros P, Levenson R: Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene. Mamm Genome. 1998 Feb;9(2):136-43. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09479Rubidium Rb-82approved, investigationalnosubstrateDetails
DB09020BisacodylapprovedunknowninhibitorDetails
DB16690TegoprazaninvestigationalyesinhibitorDetails