Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Details
- Name
- Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
- Synonyms
- 2.7.1.49
- HMP kinase
- HMP-P kinase
- HMP-phosphate kinase
- HMPP kinase
- Hydroxymethylpyrimidine kinase
- Hydroxymethylpyrimidine phosphate kinase
- Gene Name
- thiD
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Amino acid sequence
>lcl|BSEQ0019118|Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase MQRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSVITALVAQNTCGVQSVYRIEPDFV AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLQRHHVRNVVLDTVMLAKSGDPLLSPS AIETLRVRLLPQVSLITPNLPEAAALLDAPHARTEQEMLAQGRALLAMGCEAVLMKGGHL EDAQSPDWLFTREGEQRFSAPRVNTKNTHGTGCTLSAALAALRPRHRSWGETVNEAKAWL SAALAQADTLEVGKGIGPVHHFHAWW
- Number of residues
- 266
- Molecular Weight
- 28543.305
- Theoretical pI
- 6.42
- GO Classification
- FunctionsATP binding / hydroxymethylpyrimidine kinase activity / phosphomethylpyrimidine kinase activityProcessesthiamine biosynthetic process / thiamine diphosphate biosynthetic process
- General Function
- Phosphomethylpyrimidine kinase activity
- Specific Function
- Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.
- Pfam Domain Function
- Phos_pyr_kin (PF08543)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019119|Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (thiD) ATGCAACGAATTAACGCGCTGACGATTGCCGGCACCGATCCCAGCGGCGGGGCCGGTATC CAGGCGGATCTCAAGACCTTTTCCGCGCTGGGCGCATATGGCTGTTCGGTCATCACTGCG CTGGTGGCGCAAAATACCTGTGGCGTACAGTCGGTGTACCGGATAGAGCCGGACTTTGTT GCCGCTCAACTTGATTCCGTGTTCAGCGATGTGCGCATTGATACCACGAAAATCGGGATG CTGGCGGAAACCGATATTGTCGAGGCCGTGGCGGAACGGTTACAGCGCCATCATGTACGT AATGTGGTGCTGGATACGGTGATGCTGGCGAAAAGCGGCGATCCGCTGCTCTCGCCCTCT GCGATAGAAACATTACGCGTCCGGCTGTTGCCGCAGGTATCGCTGATTACGCCTAATTTG CCGGAAGCCGCAGCGTTGCTGGATGCGCCCCATGCGCGTACGGAACAGGAGATGCTGGCG CAGGGGCGGGCGTTACTGGCGATGGGGTGTGAAGCGGTATTGATGAAAGGCGGGCATTTA GAGGATGCGCAAAGCCCGGACTGGCTCTTTACCCGCGAGGGCGAGCAGCGTTTTAGCGCG CCGCGTGTGAACACCAAAAATACGCATGGGACGGGCTGTACGCTGTCGGCGGCGCTGGCG GCGTTACGGCCCCGGCATCGCAGTTGGGGAGAGACGGTAAACGAGGCGAAGGCATGGCTT TCGGCGGCGCTGGCGCAGGCGGACACGCTGGAAGTGGGGAAGGGCATTGGTCCGGTACAT CATTTCCACGCGTGGTGGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P55882 UniProtKB Entry Name THID_SALTY GenBank Protein ID 1842117 GenBank Gene ID U87940 - General References
- Petersen LA, Downs DM: Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis. J Bacteriol. 1997 Aug;179(15):4894-900. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Cheng G, Bennett EM, Begley TP, Ealick SE: Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Structure. 2002 Feb;10(2):225-35. [Article]