2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase

Details

Name
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
Synonyms
Not Available
Gene Name
cumD
UniProtKB Entry
P96965TrEMBL
Organism
Pseudomonas fluorescens
NCBI Taxonomy ID
294
Amino acid sequence
>lcl|BSEQ0022031|2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase
MANLEIGKSILAAGVLTNYHDVGEGQPVILIHGSGPGVSAYANWRLTIPALSKFYRVIAP
DMVGFGFTDRPENYNYSKDSWVDHIIGIMDALEIEKAHIVGNSFGGGLAIATALRYSERV
DRMVLMGAAGTRFDVTEGLNAVWGYTPSIENMRNLLDIFAYDRSLVTDELARLRYEASIQ
PGFQESFSSMFPEPRQRWIDALASSDEDIKTLPNETLIIHGREDQVVPLSSSLRLGELID
RAQLHVFGRCGHWTQIEQTDRFNRLVVEFFNEANTPKLVGRP
Number of residues
282
Molecular Weight
31489.385
Theoretical pI
5.03
GO Classification
Functions
hydrolase activity
General Function
Not Available
Specific Function
hydrolase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0005375|849 bp
ATGGCAAACCTGGAAATAGGTAAAAGTATTTTAGCTGCAGGGGTTCTAACAAACTATCAC
GATGTCGGGGAGGGACAGCCTGTGATACTAATTCATGGTTCTGGGCCCGGCGTGAGCGCT
TATGCGAATTGGCGACTGACCATTCCTGCTCTGAGCAAGTTTTATCGTGTTATCGCCCCT
GATATGGTTGGTTTTGGCTTTACGGATCGACCTGAAAACTATAATTATTCCAAGGATAGT
TGGGTTGACCATATAATCGGTATTATGGACGCCCTGGAAATAGAAAAGGCTCACATCGTA
GGTAACTCATTCGGTGGGGGGCTGGCGATTGCTACCGCGCTTCGTTATTCGGAGCGCGTT
GATCGTATGGTTCTGATGGGGGCGGCCGGTACTCGCTTTGACGTGACAGAGGGCCTGAAC
GCGGTGTGGGGTTACACGCCGTCGATAGAAAACATGCGTAATCTCCTCGATATATTCGCT
TATGATCGCTCCTTAGTCACCGACGAATTAGCGAGACTTCGATATGAGGCGAGTATTCAG
CCAGGATTTCAAGAGTCATTCTCCAGCATGTTTCCTGAGCCGCGCCAACGCTGGATAGAC
GCGTTGGCTAGCTCGGATGAAGATATCAAGACTCTTCCCAATGAGACACTGATTATTCAT
GGTCGAGAGGATCAGGTTGTTCCTCTATCCAGCAGTCTGCGTCTAGGCGAACTTATCGAC
CGGGCGCAGTTGCATGTTTTCGGGCGATGTGGGCACTGGACACAAATTGAGCAGACTGAC
CGATTCAATCGTCTTGTGGTCGAGTTTTTTAATGAGGCCAACACACCTAAACTAGTGGGT
CGTCCGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP96965
UniProtKB Entry NameP96965_PSEFL
GenBank Gene IDD83955
PDB ID(s)1IUN, 1IUO, 1IUP, 1UK6, 1UK7, 1UK8, 1UK9, 1UKA, 1UKB, 2D0D
General References
  1. Fushinobu S, Saku T, Hidaka M, Jun SY, Nojiri H, Yamane H, Shoun H, Omori T, Wakagi T: Crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with cleavage products. Protein Sci. 2002 Sep;11(9):2184-95. [Article]
  2. Fushinobu S, Jun SY, Hidaka M, Nojiri H, Yamane H, Shoun H, Omori T, Wakagi T: A series of crystal structures of a meta-cleavage product hydrolase from Pseudomonas fluorescens IP01 (CumD) complexed with various cleavage products. Biosci Biotechnol Biochem. 2005 Mar;69(3):491-8. [Article]
  3. Jun SY, Fushinobu S, Nojiri H, Omori T, Shoun H, Wakagi T: Improving the catalytic efficiency of a meta-cleavage product hydrolase (CumD) from Pseudomonas fluorescens IP01. Biochim Biophys Acta. 2006 Jul;1764(7):1159-66. Epub 2006 Jun 7. [Article]

Associated Data

Bio-Entities
Bio-EntityType
2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase (Pseudomonas fluorescens)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N-Valeric AcidexperimentalunknowntargetDetails
Isobutyric acidexperimentalunknowntargetDetails
Butyric Acidexperimental, investigationalunknowntargetDetails
2-Methylbutanoic AcidexperimentalunknowntargetDetails
Isovaleric AcidexperimentalunknowntargetDetails
Propanoic acidapproved, vet_approvedunknowntargetDetails
Benzoic acidapproved, investigationalunknowntargetDetails