Inter-alpha-trypsin inhibitor heavy chain H3
Details
- Name
- Inter-alpha-trypsin inhibitor heavy chain H3
- Synonyms
- Inter-alpha-inhibitor heavy chain 3
- ITI heavy chain H3
- ITI-HC3
- Serum-derived hyaluronan-associated protein
- SHAP
- Gene Name
- ITIH3
- UniProtKB Entry
- Q06033Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049872|Inter-alpha-trypsin inhibitor heavy chain H3 MAFAWWPCLILALLSSLAASGFPRSPFRLLGKRSLPEGVANGIEVYSTKINSKVTSRFAH NVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVS QGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVK HFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCT DSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKL EQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTFVKSMEDKGMT NINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKF PLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYP ENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEME KALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTS MVVTKPEDNEDERAIADKPGEDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPE KDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGIANAQM DFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQ VWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVK NHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF
- Number of residues
- 890
- Molecular Weight
- 99848.575
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes
- Specific Function
- endopeptidase inhibitor activity
- Pfam Domain Function
- Signal Regions
- 1-20
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049873|Inter-alpha-trypsin inhibitor heavy chain H3 (ITIH3) ATGGCATTTGCATGGTGGCCCTGTCTCATCTTGGCTCTGCTCTCCAGCTTGGCAGCCTCT GGCTTCCCGAGAAGCCCCTTTCGGCTGCTTGGGAAACGGAGCCTCCCGGAAGGGGTGGCC AATGGCATCGAGGTCTACAGTACCAAAATCAACTCCAAGGTGACCTCCCGTTTTGCTCAC AATGTTGTCACCATGAGAGCCGTCAACCGTGCAGACACGGCCAAGGAGGTTTCCTTTGAT GTGGAGCTGCCCAAGACGGCCTTCATCACCAACTTCACCTTGACCATCGACGGTGTTACC TACCCTGGGAATGTCAAGGAGAAGGAAGTTGCCAAGAAGCAGTATGAAAAGGCTGTGTCC CAGGGCAAGACGGCCGGCTTGGTCAAGGCCTCTGGGAGGAAGTTGGAGAAGTTCACAGTC TCGGTCAACGTGGCTGCAGGCAGCAAAGTCACCTTCGAGCTAACCTACGAGGAGCTGCTG AAGAGGCACAAGGGCAAGTACGAGATGTACCTCAAGGTCCAGCCTAAGCAACTGGTCAAA CACTTTGAGATCGAGGTAGACATCTTCGAGCCTCAGGGAATCAGCATGCTGGATGCTGAG GCCTCTTTCATCACCAACGACCTCCTGGGAAGCGCCCTCACCAAGTCCTTCTCAGGGAAA AAGGGCCATGTGTCCTTCAAGCCCAGCTTAGACCAACAGCGTTCATGCCCAACCTGTACA GACTCCCTCCTCAATGGAGATTTCACTATCACCTATGACGTGAACAGAGAATCTCCTGGC AACGTGCAGATAGTCAATGGCTACTTCGTGCACTTCTTTGCACCTCAAGGCCTTCCAGTG GTGCCTAAGAACGTGGCCTTTGTGATTGACATCAGCGGCTCCATGGCTGGTCGGAAATTA GAGCAGACAAAGGAGGCCCTTCTCAGAATCCTGGAAGATATGCAAGAGGAAGACTATCTG AATTTCATCCTGTTCAGTGGAGATGTGTCCACATGGAAAGAGCACTTAGTCCAGGCCACG CCCGAGAACCTCCAGGAGGCCAGGACGTTTGTGAAGAGCATGGAGGATAAAGGAATGACC AACATCAATGACGGGCTGCTGAGGGGCATCAGTATGCTGAACAAGGCCCGAGAGGAGCAC AGAATCCCAGAGAGGAGCACCTCCATTGTCATCATGCTGACTGATGGGGATGCCAATGTT GGTGAGAGCAGACCCGAAAAAATCCAAGAGAATGTGCGGAATGCCATCGGGGGCAAGTTC CCCTTGTATAACCTGGGCTTTGGCAACAATCTGAATTATAACTTCCTGGAGAACATGGCC CTGGAGAACCATGGGTTTGCCCGGCGCATTTATGAGGACTCTGATGCCGATTTGCAGTTG CAGGGCTTCTATGAGGAGGTGGCCAACCCACTGCTGACGGGTGTGGAGATGGAGTACCCC GAGAACGCTATCCTGGACCTCACCCAGAACACTTACCAGCACTTCTACGATGGCTCTGAG ATCGTGGTGGCCGGGCGCCTGGTGGACGAGGACATGAACAGCTTTAAGGCAGATGTGAAG GGCCATGGGGCCACCAACGACCTGACCTTCACAGAGGAGGTGGACATGAAGGAGATGGAG AAGGCCCTGCAGGAGCGGGACTACATCTTCGGGAATTACATTGAGCGGCTCTGGGCCTAC CTCACCATTGAGCAGCTGCTGGAGAAGCGCAAGAACGCCCATGGCGAGGAGAAGGAGAAC CTCACGGCCCGGGCCCTGGACCTGTCCCTCAAGTATCACTTTGTGACTCCACTGACCTCA ATGGTGGTGACCAAGCCTGAGGACAACGAGGATGAGAGGGCCATTGCCGACAAGCCTGGG GAAGATGCAGAAGCCACACCGGTGAGCCCCGCCATGTCCTACCTGACCAGCTACCAGCCT CCTCAAAACCCCTACTACTATGTGGACGGGGATCCCCACTTCATCATCCAAATTCCGGAG AAAGACGATGCCCTCTGCTTCAACATCGATGAAGCCCCAGGCACAGTGCTGCGCCTTATT CAGGATGCAGTCACAGGCCTCACAGTTAATGGGCAGATCACTGGCGACAAGAGAGGCAGC CCTGACTCCAAGACCAGAAAGACTTACTTTGGAAAACTGGGCATCGCCAATGCTCAGATG GACTTCCAGGTGGAGGTGACAACGGAGAAGATCACCCTGTGGAACAGGGCCGTGCCGAGC ACTTTCAGCTGGCTGGACACAGTCACAGTCACGCAGGATGGGCTGTCCATGATGATCAAC AGGAAGAACATGGTGGTCTCCTTTGGAGATGGGGTTACCTTCGTGGTCGTCCTACACCAG GTGTGGAAGAAACATCCTGTCCACCGTGACTTTCTAGGCTTCTACGTGGTGGACAGTCAC CGGATGTCAGCACAGACGCATGGGCTGCTGGGGCAATTCTTCCAACCCTTTGACTTTAAA GTGTCTGACATCCGGCCAGGCTCTGACCCCACAAAGCCAGATGCCACATTGGTGGTGAAG AACCATCAGCTGATTGTCACCAGGGGCTCCCAGAAAGACTACAGAAAGGATGCCAGCATC GGCACGAAGGTTGTCTGCTGGTTCGTCCACAACAACGGAGAAGGGCTGATTGATGGTGTC CACACTGACTACATTGTCCCCAACCTGTTTTGA
- Chromosome Location
- 3
- Locus
- 3p21.1
- External Identifiers
Resource Link UniProtKB ID Q06033 UniProtKB Entry Name ITIH3_HUMAN GeneCard ID ITIH3 HGNC ID HGNC:6168 KEGG ID hsa:3699 NCBI Gene ID 3699 - General References
- Bourguignon J, Diarra-Mehrpour M, Thiberville L, Bost F, Sesboue R, Martin JP: Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence. Eur J Biochem. 1993 Mar 15;212(3):771-6. [Article]
- Diarra-Mehrpour M, Sarafan N, Bourguignon J, Bonnet F, Bost F, Martin JP: Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage. J Biol Chem. 1998 Oct 9;273(41):26809-19. [Article]
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- Diarra-Mehrpour M, Bourguignon J, Sarafan N, Bost F, Sesboue R, Muschio-Bonnet F, Martin JP: Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes. Biochim Biophys Acta. 1994 Oct 18;1219(2):551-4. [Article]
- Enghild JJ, Thogersen IB, Pizzo SV, Salvesen G: Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. J Biol Chem. 1989 Sep 25;264(27):15975-81. [Article]
- Diarra-Mehrpour M, Bourguignon J, Sesboue R, Mattei MG, Passage E, Salier JP, Martin JP: Human plasma inter-alpha-trypsin inhibitor is encoded by four genes on three chromosomes. Eur J Biochem. 1989 Jan 15;179(1):147-54. [Article]
- Enghild JJ, Salvesen G, Hefta SA, Thogersen IB, Rutherfurd S, Pizzo SV: Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. J Biol Chem. 1991 Jan 15;266(2):747-51. [Article]
- Liu T, Qian WJ, Gritsenko MA, Camp DG 2nd, Monroe ME, Moore RJ, Smith RD: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J Proteome Res. 2005 Nov-Dec;4(6):2070-80. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Inter-alpha-trypsin inhibitor heavy chain H3 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Zinc approved, investigational unknown target Details Zinc acetate approved, investigational unknown target Details Zinc chloride approved, investigational unknown target binder Details Zinc sulfate, unspecified form approved, experimental unknown target binder Details