Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Details
- Name
- Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
- Synonyms
- KIAA0044
- PP2A B subunit isoform B'-gamma
- PP2A B subunit isoform B56-gamma
- PP2A B subunit isoform PR61-gamma
- PP2A B subunit isoform R5-gamma
- Renal carcinoma antigen NY-REN-29
- Gene Name
- PPP2R5C
- UniProtKB Entry
- Q13362Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0007198|Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPL SDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDP EEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERD FLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLK EEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPK EVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLIS DNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEK LKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAH QAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR
- Number of residues
- 524
- Molecular Weight
- 61060.235
- Theoretical pI
- 6.87
- GO Classification
- Functionsprotein phosphatase activator activity / protein phosphatase regulator activityProcessesnegative regulation of cell population proliferationComponentscytosol / Golgi apparatus / nucleoplasm
- General Function
- The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation
- Specific Function
- protein phosphatase activator activity
- Pfam Domain Function
- B56 (PF01603)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0019467|Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) ATGCCGAATAAAAACAAGAAGGAGAAAGAATCACCAAAAGCAGGGAAGAGTGGAAAAAGT TCAAAAGAAGGACAAGACACAGTAGAATCAGAGGGAACAAGTCCTGAAGAACCCTCAAGC CCTAAAGTACCACCTCCACTTCTTCCTGAGTTGCTGGTTCTTATTTTTGGTGGGCTTCAA GGAAGAGATGTTCCTCCTGCTGATCAAGAGAAGCTTTTTATCCAGAAGTTACGTCAGTGT TGCGTCCTCTTTGACTTTGTTTCTGATCCACTAAGTGACCTAAAGTGGAAGGAAGTAAAA CGAGCTGCTTTAAGTGAAATGGTAGAATATATCACCCATAATCGGAATGTGATCACAGAG CCTATTTACCCAGAAGTAGTCCATATGTTTGCAGTTAACATGTTTCGAACATTACCACCT TCCTCCAATCCTACGGGAGCGGAATTTGACCCGGAGGAAGATGAACCAACGTTAGAAGCA GCCTGGCCTCATCTACAGCTTGTTTATGAATTTTTCTTAAGATTTTTAGAGTCTCCAGAT TTCCAACCTAATATAGCGAAGAAATATATTGATCAGAAGTTTGTATTGCAGCTTTTAGAG CTCTTTGACAGTGAAGATCCTCGGGAGAGAGATTTTCTTAAAACCACCCTTCACAGAATC TATGGGAAATTCCTAGGCTTGAGAGCTTACATCAGAAAACAGATAAATAATATATTTTAT AGGTTTATTTATGAAACAGAGCATCATAATGGCATAGCAGAGTTACTGGAAATATTGGGA AGTATAATTAATGGATTTGCCTTACCACTAAAAGAAGAGCACAAGATTTTCTTATTGAAG GTGTTACTACCTTTGCACAAAGTGAAATCTCTGAGTGTCTACCATCCCCAGCTGGCATAC TGTGTAGTGCAGTTTTTAGAAAAGGACAGCACCCTCACGGAACCAGTGGTGATGGCACTT CTCAAATACTGGCCAAAGACTCACAGTCCAAAAGAAGTAATGTTCTTAAACGAATTAGAA GAGATTTTAGATGTCATTGAACCATCAGAATTTGTGAAGATCATGGAACCCCTCTTCCGG CAGTTGGCCAAATGTGTCTCCAGCCCACACTTCCAGGTGGCAGAGCGAGCTCTCTATTAC TGGAATAATGAATACATCATGAGTTTAATCAGTGACAACGCAGCGAAGATTCTGCCCATC ATGTTTCCTTCCTTGTACCGCAACTCAAAGACCCATTGGAACAAGACAATACATGGCTTG ATATACAACGCCCTGAAGCTCTTCATGGAGATGAACCAAAAGCTATTTGATGACTGTACA CAACAGTTCAAAGCAGAGAAACTAAAAGAGAAGCTAAAAATGAAAGAACGGGAAGAAGCA TGGGTTAAAATAGAAAATCTAGCCAAAGCCAATCCCCAGTACACAGTGTATAGTCAAGCC AGCACCATGAGCATTCCGGTTGCAATGGAGACAGATGGGCCTTTATTTGAAGATGTGCAG ATGCTGAGAAAGACAGTGAAGGACGAGGCTCATCAGGCACAGAAAGATCCGAAGAAGGAC CGTCCTCTTGCACGCCGCAAGTCCGAGCTGCCTCAGGACCCCCACACCAAGAAAGCCTTG GAAGCTCACTGCAGGGCCGATGAGCTGGCCTCCCAGGACGGCCGCTAG
- Chromosome Location
- 14
- Locus
- 14q32.31
- External Identifiers
Resource Link UniProtKB ID Q13362 UniProtKB Entry Name 2A5G_HUMAN GenBank Protein ID 1203812 GenBank Gene ID U37352 GeneCard ID PPP2R5C HGNC ID HGNC:9311 PDB ID(s) 2IAE, 2JAK, 2NPP, 2NYL, 2NYM, 3FGA, 5JJA, 5K6S, 5SW9, 5SWF, 6OYL, 6TOQ, 6VOY, 6VRO, 7OUF, 7OUG, 7OUH, 7PEL, 7SOY KEGG ID hsa:5527 NCBI Gene ID 5527 - General References
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- Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1994;1(5):223-9. [Article]
- McCright B, Virshup DM: Identification of a new family of protein phosphatase 2A regulatory subunits. J Biol Chem. 1995 Nov 3;270(44):26123-8. [Article]
- McCright B, Rivers AM, Audlin S, Virshup DM: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem. 1996 Sep 6;271(36):22081-9. [Article]
- Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jager D, Jager E, Knuth A, Chen YT, Old LJ: Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Int J Cancer. 1999 Nov 12;83(4):456-64. [Article]
- Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell. 2006 May;10(5):575-85. Epub 2006 Mar 30. [Article]
- Letourneux C, Rocher G, Porteu F: B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J. 2006 Feb 22;25(4):727-38. Epub 2006 Feb 2. [Article]
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- Xu Y, Xing Y, Chen Y, Chao Y, Lin Z, Fan E, Yu JW, Strack S, Jeffrey PD, Shi Y: Structure of the protein phosphatase 2A holoenzyme. Cell. 2006 Dec 15;127(6):1239-51. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid experimental unknown target Details 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid experimental unknown target Details