P-selectin glycoprotein ligand 1

Details

Name
P-selectin glycoprotein ligand 1
Synonyms
  • PSGL-1
  • Selectin P ligand
Gene Name
SELPLG
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052586|P-selectin glycoprotein ligand 1
MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPP
EMLRNSTDTTPLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAME
IQTTQPAATEAQTTQPVPTEAQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATE
AQTTQPTGLEAQTTAPAAMEAQTTAPAAMEAQTTPPAAMEAQTTQTTAMEAQTTAPEATE
AQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKRGLFIPFSVSSVTHKGIPMAA
SNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGHMYPVRNYSPT
EMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP
Number of residues
412
Molecular Weight
43200.985
Theoretical pI
Not Available
GO Classification
Functions
signaling receptor binding / virus receptor activity
Processes
cell adhesion / cellular response to interleukin-6 / hemopoiesis / leukocyte adhesive activation / leukocyte migration / leukocyte tethering or rolling
Components
integral component of membrane / integral component of plasma membrane / membrane / plasma membrane / plasma membrane raft / uropod
General Function
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
Specific Function
Signaling receptor binding
Pfam Domain Function
Not Available
Transmembrane Regions
321-341
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0052587|P-selectin glycoprotein ligand 1 (SELPLG)
ATGCCTCTGCAACTCCTCCTGTTGCTGATCCTACTGGGCCCTGGCAACAGCTTGCAGCTG
TGGGACACCTGGGCAGATGAAGCCGAGAAAGCCTTGGGTCCCCTGCTTGCCCGGGACCGG
AGACAGGCCACCGAATATGAGTACCTAGATTATGATTTCCTGCCAGAAACGGAGCCTCCA
GAAATGCTGAGGAACAGCACTGACACCACTCCTCTGACTGGGCCTGGAACCCCTGAGTCT
ACCACTGTGGAGCCTGCTGCAAGGCGTTCTACTGGCCTGGATGCAGGAGGGGCAGTCACA
GAGCTGACCACGGAGCTGGCCAACATGGGGAACCTGTCCACGGATTCAGCAGCTATGGAG
ATACAGACCACTCAACCAGCAGCCACGGAGGCACAGACCACTCAACCAGTGCCCACGGAG
GCACAGACCACTCCACTGGCAGCCACAGAGGCACAGACAACTCGACTGACGGCCACGGAG
GCACAGACCACTCCACTGGCAGCCACAGAGGCACAGACCACTCCACCAGCAGCCACGGAA
GCACAGACCACTCAACCCACAGGCCTGGAGGCACAGACCACTGCACCAGCAGCCATGGAG
GCACAGACCACTGCACCAGCAGCCATGGAAGCACAGACCACTCCACCAGCAGCCATGGAG
GCACAGACCACTCAAACCACAGCCATGGAGGCACAGACCACTGCACCAGAAGCCACGGAG
GCACAGACCACTCAACCCACAGCCACGGAGGCACAGACCACTCCACTGGCAGCCATGGAG
GCCCTGTCCACAGAACCCAGTGCCACAGAGGCCCTGTCCATGGAACCTACTACCAAAAGA
GGTCTGTTCATACCCTTTTCTGTGTCCTCTGTTACTCACAAGGGCATTCCCATGGCAGCC
AGCAATTTGTCCGTCAACTACCCAGTGGGGGCCCCAGACCACATCTCTGTGAAGCAGTGC
CTGCTGGCCATCCTAATCTTGGCGCTGGTGGCCACTATCTTCTTCGTGTGCACTGTGGTG
CTGGCGGTCCGCCTCTCCCGCAAGGGCCACATGTACCCCGTGCGTAATTACTCCCCCACC
GAGATGGTCTGCATCTCATCCCTGTTGCCTGATGGGGGTGAGGGGCCCTCTGCCACAGCC
AATGGGGGCCTGTCCAAGGCCAAGAGCCCGGGCCTGACGCCAGAGCCCAGGGAGGACCGT
GAGGGGGATGACCTCACCCTGCACAGCTTCCTCCCTTAG
Chromosome Location
12
Locus
12q24.11
External Identifiers
ResourceLink
UniProtKB IDQ14242
UniProtKB Entry NameSELPL_HUMAN
HGNC IDHGNC:10722
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB16698NeihulizumabinvestigationalunknownagonistDetails