The finished DNA sequence of human chromosome 12.
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Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA
The finished DNA sequence of human chromosome 12.
Nature. 2006 Mar 16;440(7082):346-51.
- PubMed ID
- 16541075 [ View in PubMed]
- Abstract
Human chromosome 12 contains more than 1,400 coding genes and 487 loci that have been directly implicated in human disease. The q arm of chromosome 12 contains one of the largest blocks of linkage disequilibrium found in the human genome. Here we present the finished sequence of human chromosome 12, which has been finished to high quality and spans approximately 132 megabases, representing approximately 4.5% of the human genome. Alignment of the human chromosome 12 sequence across vertebrates reveals the origin of individual segments in chicken, and a unique history of rearrangement through rodent and primate lineages. The rate of base substitutions in recent evolutionary history shows an overall slowing in hominids compared with primates and rodents.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Glutaminase liver isoform, mitochondrial Q9UI32 Details Nitric oxide synthase 1 P29475 Details Tryptophan 5-hydroxylase 2 Q8IWU9 Details Histidine ammonia-lyase P42357 Details Aldehyde dehydrogenase, mitochondrial P05091 Details Retinoic acid receptor gamma P13631 Details Scavenger receptor class B member 1 Q8WTV0 Details Amiloride-sensitive sodium channel subunit alpha P37088 Details Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic P21695 Details 5'-AMP-activated protein kinase subunit beta-1 Q9Y478 Details Serine hydroxymethyltransferase, mitochondrial P34897 Details Acid-sensing ion channel 1 P78348 Details Tyrosine--tRNA ligase, mitochondrial Q9Y2Z4 Details Voltage-dependent L-type calcium channel subunit alpha-1C Q13936 Details Monocarboxylate transporter 2 O60669 Details 4-hydroxyphenylpyruvate dioxygenase P32754 Details Activin receptor type-1-like P37023 Details ATP-binding cassette sub-family C member 9 O60706 Details Branched-chain-amino-acid aminotransferase, cytosolic P54687 Details Glyceraldehyde-3-phosphate dehydrogenase P04406 Details Methionine--tRNA ligase, cytoplasmic P56192 Details Activin receptor type-1B P36896 Details Anti-Muellerian hormone type-2 receptor Q16671 Details Acetyl-CoA carboxylase 2 O00763 Details NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 Q9UI09 Details Vitamin D3 receptor P11473 Details Potassium voltage-gated channel subfamily A member 1 Q09470 Details Hydroxycarboxylic acid receptor 3 P49019 Details Alpha-2-macroglobulin P01023 Details E3 ubiquitin-protein ligase Mdm2 Q00987 Details von Willebrand factor P04275 Details Cyclin-dependent kinase 2 P24941 Details Tumor necrosis factor receptor superfamily member 1A P19438 Details Tubulin alpha-1A chain Q71U36 Details Methionine aminopeptidase 2 P50579 Details Leukotriene A-4 hydrolase P09960 Details Bile acid receptor Q96RI1 Details Early endosome antigen 1 Q15075 Details Thioredoxin reductase 1, cytoplasmic Q16881 Details Sodium channel protein type 8 subunit alpha Q9UQD0 Details Complement C1r subcomponent P00736 Details Keratin, type II cytoskeletal 8 P05787 Details Prolow-density lipoprotein receptor-related protein 1 Q07954 Details Vesicle-associated membrane protein 1 P23763 Details Collagen alpha-1(II) chain P02458 Details DNA oxidative demethylase ALKBH2 Q6NS38 Details Cyclin-dependent kinase 4 P11802 Details Microsomal glutathione S-transferase 1 P10620 Details Diacylglycerol kinase alpha P23743 Details Voltage-dependent L-type calcium channel subunit beta-3 P54284 Details Keratin, type II cytoskeletal 7 P08729 Details Prostaglandin E synthase 3 Q15185 Details Scavenger receptor cysteine-rich type 1 protein M130 Q86VB7 Details Insulin-like growth factor I P05019 Details Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 P16615 Details Guanylyl cyclase C P25092 Details Histone deacetylase 7 Q8WUI4 Details Solute carrier organic anion transporter family member 1B3 Q9NPD5 Details Solute carrier organic anion transporter family member 1C1 Q9NYB5 Details Matrix metalloproteinase-17 Q9ULZ9 Details Matrix metalloproteinase-19 Q99542 Details Chymotrypsin-like elastase family member 1 Q9UNI1 Details Receptor-type tyrosine-protein phosphatase beta P23467 Details Triosephosphate isomerase P60174 Details Lens fiber major intrinsic protein P30301 Details Phospholipase A2 P04054 Details Polyubiquitin-C P0CG48 Details Interleukin-1 receptor-associated kinase 4 Q9NWZ3 Details Hepatocyte nuclear factor 1-alpha P20823 Details ADP-ribosylation factor-like protein 1 P40616 Details Gamma-enolase P09104 Details 2'-5'-oligoadenylate synthase 1 P00973 Details Sterol O-acyltransferase 2 O75908 Details Electroneutral sodium bicarbonate exchanger 1 Q2Y0W8 Details Sodium-coupled monocarboxylate transporter 1 Q8N695 Details Voltage-gated potassium channel KCNC2 Q96PR1 Details Sodium- and chloride-dependent GABA transporter 2 Q9NSD5 Details Sodium- and chloride-dependent betaine transporter P48065 Details 5'-AMP-activated protein kinase subunit gamma-1 P54619 Details Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 Q14571 Details Cyclic AMP-dependent transcription factor ATF-1 P18846 Details Cyclic AMP-dependent transcription factor ATF-7 P17544 Details Adhesion G-protein coupled receptor D1 Q6QNK2 Details P2X purinoceptor 4 Q99571 Details Matrix Gla protein P08493 Details Natural resistance-associated macrophage protein 2 P49281 Details Prohibitin-2 Q99623 Details Diablo IAP-binding mitochondrial protein Q9NR28 Details Keratin, type II cytoskeletal 1 P04264 Details Keratin, type II cytoskeletal 2 epidermal P35908 Details Pregnancy zone protein P20742 Details C-type lectin domain family 4 member E Q9ULY5 Details Voltage-dependent calcium channel subunit alpha-2/delta-4 Q7Z3S7 Details Serine/threonine-protein kinase 38-like Q9Y2H1 Details Serine/threonine-protein kinase TAO3 Q9H2K8 Details Serine/threonine-protein kinase ULK1 O75385 Details Calcium/calmodulin-dependent protein kinase kinase 2 Q96RR4 Details Citron Rho-interacting kinase O14578 Details Interleukin-1 receptor-associated kinase 3 Q9Y616 Details Leucine-rich repeat serine/threonine-protein kinase 2 Q5S007 Details Mitogen-activated protein kinase kinase kinase 12 Q12852 Details NUAK family SNF1-like kinase 1 O60285 Details Cyclin-dependent kinase 17 Q00537 Details Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma O75747 Details Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma Q8TBX8 Details P2X purinoceptor 7 Q99572 Details P2X purinoceptor 2 Q9UBL9 Details Receptor tyrosine-protein kinase erbB-3 P21860 Details Tyrosine-protein phosphatase non-receptor type 6 P29350 Details P-selectin glycoprotein ligand 1 Q14242 Details CD27 antigen P26842 Details G1/S-specific cyclin-D2 P30279 Details Melanocyte protein PMEL P40967 Details