Serine/threonine-protein kinase Nek5

Details

Name
Serine/threonine-protein kinase Nek5
Synonyms
  • 2.7.11.1
  • Never in mitosis A-related kinase 5
  • NimA-related protein kinase 5
Gene Name
NEK5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051876|Serine/threonine-protein kinase Nek5
MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH
PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH
DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP
YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF
QVSPRDRPSINSILKRPFLENLIPKYLTPEVIQEEFSHMLICRAGAPASRHAGKVVQKCK
IQKVRFQGKCPPRSRISVPIKRNAILHRNEWRPPAGAQKARSIKMIERPKIAAVCGHYDY
YYAQLDMLRRRAHKPSYHPIPQENTGVEDYGQETRHGPSPSQWPAEYLQRKFEAQQYKLK
VEKQLGLRPSSAEPNYNQRQELRSNGEEPRFQELPFRKNEMKEQEYWKQLEEIRQQYHND
MKEIRKKMGREPEENSKISHKTYLVKKSNLPVHQDASEGEAPVQMEFRSCCPGWSAMARS
WLTATSASQDIEKDLKQMRLQNTKESKNPEQKYKAKKGVKFEINLDKCISDENILQEEEA
MDIPNETLTFEDGMKFKEYECVKEHGDYTDKAFEKLHCPEAGFSTQTVAAVGNRRQWDGG
APQTLLQMMAVADITSTCPTGPDSESVLSVSRQEGKTKDPYSPVLILM
Number of residues
708
Molecular Weight
81444.935
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / metal ion binding / protein serine/threonine kinase activity
Processes
positive regulation of cysteine-type endopeptidase activity / positive regulation of striated muscle cell differentiation
General Function
Not Available
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051877|Serine/threonine-protein kinase Nek5 (NEK5)
ATGGATAAGTACGATGTGATTAAGGCCATCGGGCAAGGTGCCTTCGGGAAAGCATACTTA
GCTAAAGGGAAATCAGATAGCAAGCACTGTGTCATAAAAGAGATCAATTTTGAAAAGATG
CCCATACAAGAAAAAGAAGCTTCAAAGAAAGAAGTGATTCTTCTGGAAAAGATGAAACAT
CCCAACATTGTAGCCTTCTTCAATTCATTTCAAGAGAATGGCAGGCTGTTTATTGTAATG
GAATATTGTGATGGAGGGGATCTCATGAAAAGGATCAATAGACAACGGGGTGTGTTATTT
AGTGAAGATCAGATCCTCGGTTGGTTTGTACAGATTTCTCTAGGACTAAAACATATTCAT
GACAGGAAGATATTACACAGGGACATAAAAGCTCAGAACATTTTTCTTAGCAAGAACGGA
ATGGTGGCAAAGCTTGGGGACTTTGGTATAGCAAGAGTCCTGAATAATTCCATGGAACTT
GCTCGAACTTGTATTGGAACACCTTACTACCTGTCCCCAGAGATCTGTCAGAATAAACCC
TACAACAATAAAACGGATATTTGGTCTCTTGGCTGTGTCTTATATGAGCTCTGCACACTT
AAACATCCTTTTGAGGGTAACAACTTACAGCAGCTGGTTCTGAAGATTTGTCAAGCACAT
TTTGCCCCAATATCTCCGGGGTTTTCTCGTGAGCTCCATTCCTTGATATCTCAGCTCTTT
CAAGTATCTCCTCGAGACCGACCATCCATAAATTCCATTTTGAAAAGGCCCTTTTTAGAG
AATCTTATTCCCAAATATTTGACTCCTGAGGTCATTCAGGAAGAATTCAGTCACATGCTT
ATATGCAGAGCAGGAGCGCCAGCTTCTCGACATGCTGGGAAGGTGGTCCAGAAGTGTAAA
ATACAAAAAGTGAGATTCCAGGGAAAGTGCCCACCAAGATCAAGGATATCTGTGCCAATT
AAAAGGAATGCTATATTGCATAGAAATGAATGGAGACCACCAGCTGGAGCCCAGAAGGCC
AGATCTATAAAAATGATAGAAAGACCCAAAATTGCTGCTGTCTGTGGACATTATGATTAT
TATTATGCTCAACTTGATATGCTGAGGAGGAGAGCCCACAAACCAAGTTATCACCCTATT
CCTCAAGAAAATACTGGAGTTGAGGATTACGGTCAGGAAACGAGGCATGGTCCATCCCCA
AGTCAATGGCCTGCTGAGTACCTTCAGAGAAAATTTGAAGCTCAACAATATAAGTTGAAA
GTGGAGAAGCAATTGGGTCTTCGTCCATCTTCTGCCGAGCCAAATTACAACCAGAGACAA
GAGCTAAGAAGTAATGGAGAAGAGCCTAGATTCCAGGAGCTGCCATTTAGGAAAAACGAA
ATGAAGGAACAGGAATATTGGAAGCAGTTAGAGGAAATACGCCAACAGTACCACAATGAC
ATGAAAGAAATTAGAAAGAAGATGGGGAGAGAACCAGAGGAGAACTCAAAAATAAGTCAT
AAAACCTATTTGGTGAAGAAGAGTAACCTGCCTGTCCATCAAGATGCATCTGAGGGAGAA
GCACCTGTGCAGATGGAATTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCACGATCT
TGGCTCACCGCAACCTCCGCCTCCCAGGACATTGAAAAAGACTTGAAACAAATGAGGCTT
CAGAACACAAAGGAAAGTAAAAATCCAGAACAGAAATATAAAGCTAAGAAGGGGGTAAAA
TTTGAAATTAATTTAGACAAATGTATTTCTGATGAAAACATCCTCCAAGAGGAAGAGGCA
ATGGATATACCAAATGAAACTTTGACCTTTGAGGATGGCATGAAGTTTAAGGAATATGAA
TGTGTAAAGGAGCATGGAGATTATACAGACAAAGCATTTGAAAAACTTCACTGCCCAGAA
GCAGGGTTTTCCACGCAGACTGTAGCTGCTGTGGGAAACAGGAGGCAGTGGGATGGAGGA
GCGCCTCAGACTCTGCTGCAGATGATGGCAGTGGCCGACATCACCTCCACCTGCCCCACG
GGGCCTGACAGTGAGTCTGTGCTTAGCGTCAGTCGTCAGGAAGGGAAGACCAAGGACCCG
TACAGCCCAGTGCTCATCCTGATGTGA
Chromosome Location
13
Locus
13q14.3
External Identifiers
ResourceLink
UniProtKB IDQ6P3R8
UniProtKB Entry NameNEK5_HUMAN
HGNC IDHGNC:7748
General References
  1. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails