DNA-directed RNA polymerase subunit beta'
Details
- Name
- DNA-directed RNA polymerase subunit beta'
- Synonyms
- 2.7.7.6
- RNA polymerase subunit beta'
- RNAP subunit beta'
- Transcriptase subunit beta'
- Gene Name
- rpoC
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Amino acid sequence
>lcl|BSEQ0017080|DNA-directed RNA polymerase subunit beta' MKKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERDGLFDERIFGPIKDYECAC GKYKRQRFEGKVCERCGVEVTKSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSA TELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELRYGKQETYPLPPGVDALVK DGEEVVKGQELAPGVVSRLDGVALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGE ILAELPEPYLFRAEEEGVVELKELEEGAFLVLRREDEPVATYFLPVGMTPLVVHGEIVEK GQPLAEAKGLLRMPRQVRAAQVEAEEEGETVYLTLFLEWTEPKDYRVQPHMNVVVPEGAR VEAGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPFEDDVEVSTGDRVAPGDV LADGGKVKSDVYGRVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEE MKHPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDLRPMVQVDGGRFATSDL NDLYRRLINRNNRLKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPL RSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKRMALELFKPFLLKK MEEKGIAPNVKAARRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVL VEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQMLSAHNLLSPASGEPLAK PSRDIILGLYYITQVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLK YVFANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFARIVAEAVEDEKVAWELI QLDVPQEKNSLKDLVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEK KQYLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKVTQAVFKNFEENYPFNPL YVMAQSGARGNPQQIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKG GADTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQPDEVTRSLRLRKRADI EAGLYGRVLAREVEVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGV CQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRTFHTGGVAGAADITQGLPRVI ELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLVKDGDYVE AGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYVE VTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKSWLSAASF QNTTHVLTEAAIAGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEARK EAVEAKERPAARRGVKREQPGKQA
- Number of residues
- 1524
- Molecular Weight
- 170755.075
- Theoretical pI
- 6.32
- GO Classification
- FunctionsDNA binding / DNA-directed RNA polymerase activityProcessestranscription, DNA-templated
- General Function
- Dna-directed rna polymerase activity
- Specific Function
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0017081|DNA-directed RNA polymerase subunit beta' (rpoC) ATGAAAAAAGAGGTTCGTAAGGTTCGCATCGCTTTGGCCTCCCCGGAGAAGATCCGCTCC TGGAGCTACGGGGAGGTGGAGAAGCCCGAGACCATCAACTACCGCACCCTCAAGCCCGAG CGGGACGGCCTCTTTGACGAGCGCATCTTCGGCCCCATCAAGGACTACGAGTGCGCCTGC GGCAAGTACAAGCGCCAGCGCTTTGAGGGCAAGGTGTGCGAGCGGTGTGGCGTGGAGGTG ACGAAGAGCATCGTCCGCCGCTACCGCATGGGGCACATTGAGCTCGCCACCCCCGCCGCC CACATCTGGTTCGTCAAGGACGTCCCCTCCAAGATCGGGACCCTCCTGGACCTTTCCGCC ACCGAGCTGGAGCAGGTCCTCTACTTCAGCAAGTACATCGTCTTGGATCCCAAGGGGGCC ATCCTGAACGGGGTCCCGGTGGAGAAGCGCCAGCTCCTCACCGACGAGGAGTACCGGGAG CTCCGCTACGGCAAGCAGGAGACCTACCCCCTGCCCCCCGGGGTGGACGCGCTGGTGAAG GACGGGGAGGAGGTGGTAAAGGGCCAGGAGCTTGCCCCCGGGGTGGTGAGCCGCCTGGAC GGCGTGGCCCTCTACCGCTTCCCCCGCCGCGTCCGGGTGGAGTACGTGAAGAAGGAGCGG GCCGGGCTCAGGCTTCCCCTCGCCGCCTGGGTGGAGAAGGAGGCCTACAAGCCCGGCGAA ATCCTCGCCGAGCTCCCCGAGCCCTACCTCTTCCGGGCCGAGGAGGAGGGCGTGGTGGAG CTTAAGGAGCTGGAGGAAGGGGCTTTCCTCGTCCTCCGCCGGGAGGACGAGCCGGTGGCC ACCTACTTCCTCCCCGTGGGCATGACGCCCCTCGTGGTCCACGGGGAGATCGTGGAGAAG GGCCAGCCCCTGGCCGAGGCCAAGGGCCTTCTCCGCATGCCCCGCCAGGTCCGGGCCGCC CAGGTGGAGGCGGAGGAGGAGGGGGAGACGGTCTACCTCACCCTCTTCCTGGAGTGGACG GAGCCCAAGGACTACCGCGTCCAGCCCCACATGAACGTGGTGGTCCCCGAGGGGGCCCGG GTGGAGGCGGGGGACAAGATCGTGGCCGCCATTGACCCCGAGGAGGAGGTCATCGCCGAG GCCGAGGGGGTGGTCCACCTCCACGAGCCCGCCAGCATCCTGGTGGTCAAGGCCCGGGTC TACCCCTTTGAGGACGACGTGGAGGTTTCCACCGGGGACCGGGTGGCCCCGGGGGACGTC CTCGCCGACGGGGGCAAGGTCAAAAGCGACGTCTACGGCCGGGTGGAGGTGGACCTGGTC CGCAACGTGGTCCGGGTGGTGGAGTCCTACGACATTGACGCCCGCATGGGGGCCGAGGCC ATCCAGCAGCTCCTCAAGGAGCTGGACCTCGAGGCCCTGGAGAAGGAGCTTCTGGAGGAG ATGAAGCACCCCTCCCGGGCCCGGCGGGCCAAGGCCAGGAAGCGCCTGGAGGTGGTGCGG GCCTTCCTGGACTCGGGGAACCGGCCCGAGTGGATGATCCTCGAGGCCGTCCCCGTCCTT CCCCCGGACCTCCGGCCCATGGTCCAGGTGGACGGCGGCCGCTTCGCCACGAGCGACCTC AACGACCTCTACCGCCGCCTCATCAACCGCAACAACCGGCTGAAGAAGCTCTTGGCCCAG GGGGCCCCCGAGATCATCATCCGCAACGAGAAGCGGATGCTCCAGGAGGCGGTGGACGCC CTCCTGGACAACGGCCGCCGCGGCGCTCCCGTGACCAACCCCGGCTCCGACCGGCCCCTC CGTAGCCTCACCGACATCCTCTCCGGCAAGCAGGGCCGCTTCCGCCAGAACCTCTTGGGC AAGCGGGTGGACTACTCGGGCCGGAGCGTGATCGTGGTGGGGCCCCAGCTCAAGCTCCAC CAGTGCGGCCTGCCCAAGCGGATGGCCCTGGAGCTCTTCAAGCCCTTCCTCCTCAAGAAG ATGGAGGAGAAGGGCATCGCCCCCAACGTCAAGGCGGCGCGGCGCATGCTGGAGCGCCAG CGGGACATCAAGGACGAGGTGTGGGACGCCTTGGAGGAGGTGATCCACGGCAAGGTGGTC CTCTTGAACCGCGCCCCCACCCTGCACCGCTTGGGCATCCAGGCCTTCCAGCCCGTCTTG GTGGAGGGGCAGTCCATCCAGCTCCACCCCCTGGTCTGCGAGGCCTTCAACGCCGACTTT GACGGGGACCAGATGGCCGTCCACGTCCCCCTCTCCTCCTTCGCCCAGGCCGAGGCCCGC ATCCAGATGCTCTCCGCCCACAACCTCCTCTCCCCGGCCTCCGGGGAGCCCCTGGCCAAG CCCAGCCGGGACATCATCCTGGGCCTCTACTACATCACCCAGGTGCGCAAGGAGAAGAAG GGGGCGGGCCTGGAGTTCGCCACCCCCGAGGAGGCCCTGGCCGCCCACGAGCGGGGAGAG GTGGCCCTGAACGCCCCCATCAAGGTGGCGGGCAGGGAGACCAGCGTGGGCCGGCTCAAG TACGTCTTCGCCAACCCCGACGAGGCCCTCCTCGCCGTGGCCCACGGCATCGTGGACCTG CAGGACGTGGTCACCGTCCGCTACATGGGCAAGCGGCTGGAGACGAGCCCGGGCCGCATC CTCTTCGCCCGCATCGTGGCCGAGGCGGTGGAGGACGAGAAGGTGGCCTGGGAGCTCATC CAGCTGGACGTGCCCCAGGAGAAGAACTCCCTCAAGGACCTGGTCTACCAGGCCTTCCTC CGCCTGGGGATGGAGAAGACCGCCAGGCTCCTGGACGCCCTCAAGTACTACGGCTTCACC TTCTCCACCACGAGCGGCATCACCATCGGCATTGACGACGCCGTGATCCCGGAGGAGAAG AAGCAGTACCTGGAGGAGGCCGACCGCAAGCTCCTCCAGATTGAGCAGGCCTACGAGATG GGCTTCCTCACCGACCGGGAGCGGTACGACCAGATCCTCCAGCTCTGGACCGAGACCACG GAGAAGGTCACCCAGGCGGTCTTCAAGAACTTTGAGGAGAACTACCCCTTCAACCCCCTC TACGTCATGGCCCAGTCCGGGGCCCGGGGCAACCCGCAGCAGATCCGCCAGCTCTGCGGC CTGCGCGGCCTCATGCAGAAGCCCTCGGGCGAGACCTTTGAGGTGCCGGTGCGCTCCTCC TTCCGCGAGGGCCTCACCGTCTTGGAGTACTTCATCTCCAGCCACGGGGCCCGTAAGGGC GGGGCGGACACCGCCCTCCGCACCGCCGACTCCGGCTACCTCACCCGCAAGCTCGTGGAC GTGACCCACGAGATCGTGGTGCGGGAGGCGGACTGCGGCACCACCAACTACATCTCCGTT CCCCTCTTCCAGCCCGACGAGGTGACCCGCTCCTTGCGCCTGAGGAAGCGCGCGGACATT GAGGCGGGCCTCTACGGGCGCGTCCTGGCCCGGGAGGTGGAGGTCCTGGGGGTGCGCCTC GAGGAGGGCCGCTACCTCTCCATGGACGACGTCCACCTCCTCATCAAGGCCGCCGAGGCC GGGGAGATCCAGGAGGTGCCCGTCCGCAGCCCCCTCACCTGCCAGACCCGCTACGGGGTC TGCCAGAAGTGCTACGGGTACGACCTCTCCATGGCCCGGCCCGTCTCCATCGGCGAGGCG GTGGGCATCGTGGCCGCCCAGTCCATCGGCGAGCCCGGCACCCAGCTCACCATGCGCACC TTCCACACGGGCGGCGTGGCCGGGGCCGCGGACATCACCCAGGGTCTGCCCCGCGTCATT GAGCTCTTTGAGGCCCGGCGCCCCAAGGCCAAGGCGGTGATCTCCGAGATTGACGGGGTG GTGCGCATTGAGGAGACGGAGGAGAAGCTCTCCGTCTTCGTGGAGTCCGAGGGCTTCTCC AAGGAGTACAAGCTCCCCAAGGAGGCGCGCCTTCTCGTCAAGGACGGGGACTACGTGGAG GCGGGCCAGCCCCTCACCCGCGGGGCCATTGACCCCCACCAGCTCTTGGAGGCCAAGGGC CCCGAGGCGGTGGAGCGCTACCTGGTGGAGGAGATCCAGAAGGTCTACCGGGCCCAGGGC GTGAAGCTGCACGACAAGCACATTGAGATCGTGGTCCGGCAGATGATGAAGTACGTGGAG GTCACCGACCCCGGGGACAGCCGCCTCCTCGAGGGCCAGGTCCTGGAGAAGTGGGACGTG GAGGCCCTGAACGAGAGGCTCATCGCCGAGGGCAAGACCCCGGTGGCCTGGAAGCCCCTC CTCATGGGGGTCACGAAGAGCGCCCTCTCCACCAAGAGCTGGCTCTCCGCCGCCAGCTTC CAGAACACCACCCACGTCCTCACCGAGGCGGCCATCGCCGGGAAGAAGGACGAGCTCATC GGCCTCAAGGAGAACGTCATCCTGGGCCGCCTGATCCCGGCGGGCACGGGTTCGGACTTC GTCCGCTTCACCCAGGTGGTGGACCAGAAGACCCTGAAGGCCATTGAGGAGGCCCGCAAG GAGGCGGTGGAGGCCAAGGAGCGGCCCGCCGCCCGGCGCGGGGTCAAGCGGGAGCAGCCC GGCAAGCAGGCTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8RQE8 UniProtKB Entry Name RPOC_THET8 GenBank Gene ID AB083790 - General References
- Vassylyeva MN, Lee J, Sekine SI, Laptenko O, Kuramitsu S, Shibata T, Inoue Y, Borukhov S, Vassylyev DG, Yokoyama S: Purification, crystallization and initial crystallographic analysis of RNA polymerase holoenzyme from Thermus thermophilus. Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1497-500. Epub 2002 Aug 23. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04788 Tagetitoxin experimental unknown Details DB08226 Myxopyronin B experimental unknown Details DB08266 Methyl [(1E,5R)-5-{3-[(2E,4E)-2,5-dimethyl-2,4-octadienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate experimental unknown Details