UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Details
- Name
- UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
- Synonyms
- 2.6.1.87
- pbgP
- pbgP1
- pmrH
- Polymyxin resistance protein PmrH
- UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase
- UDP-4-amino-4-deoxy-L-arabinose aminotransferase
- UDP-Ara4O aminotransferase
- Gene Name
- arnB
- UniProtKB Entry
- Q8ZNF3Swiss-Prot
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- NCBI Taxonomy ID
- 99287
- Amino acid sequence
>lcl|BSEQ0003002|UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase MSDFLPFSRPAMGAEELAAVKTVLDSGWITTGPKNQELEAAFCRLTGNQYAVAVSSATAG MHIALMALGIGEGDEVITPSMTWVSTLNMIVLLGANPVMVDVDRDTLMVTPEHIEAAITP QTKAIIPVHYAGAPADLDAIYALGERYGIPVIEDAAHATGTSYKGRHIGARGTAIFSFHA IKNITCAEGGIVVTDNPQFADKLRSLKFHGLGVDAWDRQSGGRAPQAEVLAPGYKYNLPD LNAAIALAQLQKLDALNARRAAIAAQYHQAMADLPFQPLSLPSWEHIHAWHLFIIRVDEA RCGITRDALMASLKTKGIGTGLHFRAAHTQKYYRERFPTLTLPDTEWNSERICSLPLFPD MTESDFDRVITALHQIAGQ
- Number of residues
- 379
- Molecular Weight
- 41164.65
- Theoretical pI
- 6.27
- GO Classification
- Functionstransaminase activityProcesseslipid A biosynthetic process / lipopolysaccharide biosynthetic process / response to antibiotic
- General Function
- Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) (PubMed:12429098, PubMed:24460375). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).
- Specific Function
- pyridoxal phosphate binding
- Pfam Domain Function
- DegT_DnrJ_EryC1 (PF01041)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0019127|UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (arnB) ATGTCGGACTTTTTGCCTTTCTCCCGTCCGGCGATGGGCGCGGAAGAGCTTGCTGCCGTT AAGACCGTACTGGACTCAGGTTGGATAACAACCGGCCCGAAAAATCAGGAACTGGAAGCG GCGTTTTGTCGGCTAACTGGCAATCAATATGCCGTTGCCGTCAGTTCAGCCACTGCCGGT ATGCACATCGCGTTGATGGCGCTGGGCATTGGTGAAGGCGACGAGGTCATTACACCGTCA ATGACGTGGGTTTCTACGCTAAATATGATCGTTTTACTCGGCGCGAACCCCGTCATGGTC GATGTCGATCGCGATACGCTGATGGTCACGCCTGAACATATCGAAGCCGCGATTACGCCA CAAACCAAAGCAATTATCCCCGTCCACTACGCTGGCGCGCCCGCCGATCTGGACGCTATT TACGCTCTTGGCGAGCGTTATGGCATTCCAGTGATTGAAGACGCGGCGCACGCGACAGGA ACCAGCTACAAAGGTCGCCACATTGGCGCCCGGGGCACCGCGATTTTCTCCTTCCACGCC ATTAAGAACATTACCTGCGCTGAAGGCGGTATCGTCGTCACGGATAACCCGCAATTCGCC GATAAACTGCGCAGTCTCAAGTTTCACGGGCTTGGCGTTGATGCCTGGGATCGACAGAGC GGGGGACGCGCGCCACAAGCGGAAGTCCTGGCGCCGGGCTACAAATATAATTTGCCCGAC CTCAACGCCGCTATCGCGCTTGCCCAGTTACAGAAACTGGATGCGCTTAACGCTCGACGC GCCGCCATCGCAGCGCAGTACCACCAGGCAATGGCAGACCTGCCTTTTCAGCCTCTGAGC CTTCCGTCGTGGGAGCATATTCACGCCTGGCATTTATTCATTATCCGGGTCGATGAAGCC CGCTGCGGTATTACCCGGGATGCTCTGATGGCATCGCTGAAAACGAAAGGCATCGGCACA GGGCTGCATTTCCGCGCCGCGCATACGCAAAAATATTATCGCGAACGTTTCCCAACGCTC ACGCTGCCTGACACCGAGTGGAACAGCGAGCGGATCTGCTCACTGCCGCTCTTCCCGGAC ATGACCGAGAGTGACTTTGATCGAGTCATTACCGCCCTTCATCAGATAGCAGGACAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8ZNF3 UniProtKB Entry Name ARNB_SALTY GenBank Protein ID 2921419 GenBank Gene ID AF036677 PDB ID(s) 1MDO, 1MDX, 1MDZ KEGG ID stm:STM2297 NCBI Gene ID 1253819 - General References
- Gunn JS, Lim KB, Krueger J, Kim K, Guo L, Hackett M, Miller SI: PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. Mol Microbiol. 1998 Mar;27(6):1171-82. [Article]
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Wosten MM, Groisman EA: Molecular characterization of the PmrA regulon. J Biol Chem. 1999 Sep 17;274(38):27185-90. [Article]
- Noland BW, Newman JM, Hendle J, Badger J, Christopher JA, Tresser J, Buchanan MD, Wright TA, Rutter ME, Sanderson WE, Muller-Dieckmann HJ, Gajiwala KS, Buchanan SG: Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: a 4-amino-4-deoxy-L-arabinose lipopolysaccharide-modifying enzyme. Structure. 2002 Nov;10(11):1569-80. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Pyridoxamine-5'-Phosphate experimental unknown target Details D-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-N,O-cycloserylamide experimental unknown target Details