Bcl2-associated agonist of cell death
Details
- Name
- Bcl2-associated agonist of cell death
- Synonyms
- BAD
- BBC6
- Bcl-2-binding component 6
- Bcl-2-like protein 8
- Bcl-xL/Bcl-2-associated death promoter
- Bcl2 antagonist of cell death
- Bcl2-L-8
- BCL2L8
- Gene Name
- BAD
- UniProtKB Entry
- Q92934Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0006675|Bcl2-associated agonist of cell death MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
- Number of residues
- 168
- Molecular Weight
- 18391.765
- Theoretical pI
- 7.19
- GO Classification
- Functionsprotein phosphatase bindingProcessespositive regulation of intrinsic apoptotic signaling pathway in response to osmotic stressComponentsBAD-BCL-2 complex
- General Function
- Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways
- Specific Function
- cysteine-type endopeptidase activator activity involved in apoptotic process
- Pfam Domain Function
- Bcl-2_BAD (PF10514)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion outer membrane
- Gene sequence
>lcl|BSEQ0021355|Bcl2-associated agonist of cell death (BAD) ATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGG GGCCTGGGCCCCAGCCCCGCAGGGGACGGGCCCTCAGGCTCCGGCAAGCATCATCGCCAG GCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCAT CATGGAGGCGCTGGGGCTGTGGAGATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGACG GAGGACGACGAAGGGATGGGGGAGGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCG CCCCCCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGAG TTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAG ATGCGGCAAAGCTCCAGCTGGACGCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGGC AGGGGAAGCTCCGCCCCCTCCCAGTGA
- Chromosome Location
- 11
- Locus
- 11q13.1
- External Identifiers
Resource Link UniProtKB ID Q92934 UniProtKB Entry Name BAD_HUMAN GenBank Gene ID U66879 GeneCard ID BAD GenAtlas ID BAD HGNC ID HGNC:936 PDB ID(s) 1G5J, 7Q16 KEGG ID hsa:572 NCBI Gene ID 572 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Bcl2-associated agonist of cell death (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Navitoclax investigational unknown target Details