Bcl2-associated agonist of cell death
Details
- Name
- Bcl2-associated agonist of cell death
- Synonyms
- BAD
- BBC6
- Bcl-2-binding component 6
- Bcl-2-like protein 8
- Bcl-xL/Bcl-2-associated death promoter
- Bcl2 antagonist of cell death
- Bcl2-L-8
- BCL2L8
- Gene Name
- BAD
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006675|Bcl2-associated agonist of cell death MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSH HGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDE FVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
- Number of residues
- 168
- Molecular Weight
- 18391.765
- Theoretical pI
- 7.19
- GO Classification
- Functionscysteine-type endopeptidase activator activity involved in apoptotic process / lipid binding / phospholipid binding / protein kinase bindingProcessesactivation of cysteine-type endopeptidase activity / activation of cysteine-type endopeptidase activity involved in apoptotic process / ADP metabolic process / apoptotic process / apoptotic signaling pathway / ATP metabolic process / cellular process regulating host cell cycle in response to virus / cellular response to chromate / cellular response to hypoxia / cellular response to lipid / cellular response to mechanical stimulus / cellular response to nicotine / cytokine-mediated signaling pathway / epidermal growth factor receptor signaling pathway / extrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway via death domain receptors / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / glucose catabolic process / glucose homeostasis / innate immune response / intrinsic apoptotic signaling pathway / intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of cytolysis / neurotrophin TRK receptor signaling pathway / phosphatidylinositol-mediated signaling / pore complex assembly / positive regulation of apoptotic process / positive regulation of apoptotic process by virus / positive regulation of autophagy / positive regulation of B cell differentiation / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of epithelial cell proliferation / positive regulation of glucokinase activity / positive regulation of insulin secretion / positive regulation of insulin secretion involved in cellular response to glucose stimulus / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of mitochondrial membrane potential / positive regulation of neuron death / positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / positive regulation of proteolysis / positive regulation of release of cytochrome c from mitochondria / positive regulation of T cell differentiation / positive regulation of type B pancreatic cell development / programmed cell death / regulation of mitochondrial membrane permeability / release of cytochrome c from mitochondria / response to amino acid / response to calcium ion / response to drug / response to estradiol / response to ethanol / response to glucocorticoid / response to glucose / response to hydrogen peroxide / response to oleic acid / response to progesterone / response to testosterone / suppression by virus of host apoptotic process / type B pancreatic cell proliferationComponentscytosol / mitochondrial outer membrane / mitochondrion
- General Function
- Protein kinase binding
- Specific Function
- Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
- Pfam Domain Function
- Bcl-2_BAD (PF10514)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion outer membrane
- Gene sequence
>lcl|BSEQ0021355|Bcl2-associated agonist of cell death (BAD) ATGTTCCAGATCCCAGAGTTTGAGCCGAGTGAGCAGGAAGACTCCAGCTCTGCAGAGAGG GGCCTGGGCCCCAGCCCCGCAGGGGACGGGCCCTCAGGCTCCGGCAAGCATCATCGCCAG GCCCCAGGCCTCCTGTGGGACGCCAGTCACCAGCAGGAGCAGCCAACCAGCAGCAGCCAT CATGGAGGCGCTGGGGCTGTGGAGATCCGGAGTCGCCACAGCTCCTACCCCGCGGGGACG GAGGACGACGAAGGGATGGGGGAGGAGCCCAGCCCCTTTCGGGGCCGCTCGCGCTCGGCG CCCCCCAACCTCTGGGCAGCACAGCGCTATGGCCGCGAGCTCCGGAGGATGAGTGACGAG TTTGTGGACTCCTTTAAGAAGGGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAG ATGCGGCAAAGCTCCAGCTGGACGCGAGTCTTCCAGTCCTGGTGGGATCGGAACTTGGGC AGGGGAAGCTCCGCCCCCTCCCAGTGA
- Chromosome Location
- 11
- Locus
- 11q13.1
- External Identifiers
Resource Link UniProtKB ID Q92934 UniProtKB Entry Name BAD_HUMAN GenBank Gene ID U66879 GenAtlas ID BAD HGNC ID HGNC:936 - General References
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