Interphotoreceptor matrix proteoglycan 2
Details
- Name
- Interphotoreceptor matrix proteoglycan 2
- Synonyms
- Interphotoreceptor matrix proteoglycan of 200 kDa
- IPM 200
- IPM200
- Sialoprotein associated with cones and rods proteoglycan
- Spacrcan
- Gene Name
- IMPG2
- UniProtKB Entry
- Q9BZV3Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0017566|Interphotoreceptor matrix proteoglycan 2 MIMFPLFGKISLGILIFVLIEGDFPSLTAQTYLSIEEIQEPKSAVSFLLPEESTDLSLAT KKKQPLDRRETERQWLIRRRRSILFPNGVKICPDESVAEAVANHVKYFKVRVCQEAVWEA FRTFWDRLPGREEYHYWMNLCEDGVTSIFEMGTNFSESVEHRSLIMKKLTYAKETVSSSE LSSPVPVGDTSTLGDTTLSVPHPEVDAYEGASESSLERPEESISNEIENVIEEATKPAGE QIAEFSIHLLGKQYREELQDSSSFHHQHLEEEFISEVENAFTGLPGYKEIRVLEFRSPKE NDSGVDVYYAVTFNGEAISNTTWDLISLHSNKVENHGLVELDDKPTVVYTISNFRDYIAE TLQQNFLLGNSSLNPDPDSLQLINVRGVLRHQTEDLVWNTQSSSLQATPSSILDNTFQAA WPSADESITSSIPPLDFSSGPPSATGRELWSESPLGDLVSTHKLAFPSKMGLSSSPEVLE VSSLTLHSVTPAVLQTGLPVASEERTSGSHLVEDGLANVEESEDFLSIDSLPSSSFTQPV PKETIPSMEDSDVSLTSSPYLTSSIPFGLDSLTSKVKDQLKVSPFLPDASMEKELIFDGG LGSGSGQKVDLITWPWSETSSEKSAEPLSKPWLEDDDSLLPAEIEDKKLVLVDKMDSTDQ ISKHSKYEHDDRSTHFPEEEPLSGPAVPIFADTAAESASLTLPKHISEVPGVDDYSVTKA PLILTSVAISASTDKSDQADAILREDMEQITESSNYEWFDSEVSMVKPDMQTLWTILPES ERVWTRTSSLEKLSRDILASTPQSADRLWLSVTQSTKLPPTTISTLLEDEVIMGVQDISL ELDRIGTDYYQPEQVQEQNGKVGSYVEMSTSVHSTEMVSVAWPTEGGDDLSYTQTSGALV VFFSLRVTNMMFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLTGFQNLEILNFRNGSIV VNSRMKFANSVPPNVNNAVYMILEDFCTTAYNTMNLAIDKYSLDVESGDEANPCKFQACN EFSECLVNPWSGEAKCRCFPGYLSVEERPCQSLCDLQPDFCLNDGKCDIMPGHGAICRCR VGENWWYRGKHCEEFVSEPVIIGITIASVVGLLVIFSAIIYFFIRTLQAHHDRSERESPF SGSSRQPDSLSSIENAVKYNPVYESHRAGCEKYEGPYPQHPFYSSASGDVIGGLSREEIR QMYESSELSREEIQERMRVLELYANDPEFAAFVREQQVEEV
- Number of residues
- 1241
- Molecular Weight
- 138619.39
- Theoretical pI
- Not Available
- GO Classification
- Functionsextracellular matrix structural constituent / heparin binding / hyaluronic acid bindingProcessesvisual perceptionComponentsreceptor complex
- General Function
- Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin
- Specific Function
- Extracellular matrix structural constituent
- Pfam Domain Function
- SEA (PF01390)
- Signal Regions
- 1-22
- Transmembrane Regions
- 1100-1120
- Cellular Location
- Photoreceptor outer segment membrane
- Gene sequence
>lcl|BSEQ0017567|Interphotoreceptor matrix proteoglycan 2 (IMPG2) ATGATTATGTTTCCTCTTTTTGGGAAGATTTCTCTGGGTATTTTGATATTTGTCCTGATA GAAGGAGACTTTCCATCATTAACAGCACAAACCTACTTATCTATAGAGGAGATCCAAGAA CCCAAGAGTGCAGTTTCTTTTCTCCTGCCTGAAGAATCAACAGACCTTTCTCTAGCTACC AAAAAGAAACAGCCTCTGGACCGCAGAGAAACTGAAAGACAGTGGTTAATCAGAAGGCGG AGATCTATTCTGTTTCCTAATGGAGTGAAAATCTGCCCAGATGAAAGTGTTGCAGAGGCT GTGGCAAATCATGTGAAGTATTTTAAAGTCCGAGTGTGTCAGGAAGCTGTCTGGGAAGCC TTCAGGACTTTTTGGGATCGACTTCCTGGGCGTGAGGAATATCATTACTGGATGAATTTG TGTGAGGATGGAGTCACAAGTATATTTGAAATGGGCACAAATTTTAGTGAATCTGTGGAA CATAGAAGCTTAATCATGAAGAAACTGACTTATGCAAAGGAAACTGTAAGCAGCTCTGAA CTGTCTTCTCCAGTTCCTGTTGGTGATACTTCAACATTGGGAGACACTACTCTCAGTGTT CCACATCCAGAGGTGGACGCCTATGAAGGTGCCTCAGAGAGCAGCTTGGAAAGGCCAGAG GAGAGTATTAGCAATGAAATTGAGAATGTGATAGAAGAAGCCACAAAACCAGCAGGTGAA CAGATTGCAGAATTCAGTATCCACCTTTTGGGGAAGCAGTACAGGGAAGAACTACAGGAT TCCTCCAGCTTTCACCACCAGCACCTTGAAGAAGAATTTATTTCAGAGGTTGAAAATGCA TTTACTGGGTTACCAGGCTACAAGGAAATTCGTGTACTTGAATTTAGGTCCCCCAAGGAA AATGACAGTGGCGTAGATGTTTACTATGCAGTTACCTTCAATGGTGAGGCCATCAGCAAT ACCACCTGGGACCTCATTAGCCTTCACTCCAACAAGGTGGAAAACCATGGCCTTGTGGAA CTGGATGATAAACCCACTGTTGTTTATACAATCAGTAACTTCAGAGATTATATTGCTGAG ACATTGCAGCAGAATTTTTTGCTGGGGAACTCTTCCTTGAATCCAGATCCTGATTCCCTG CAGCTTATCAATGTGAGAGGAGTTTTGCGTCACCAAACTGAAGATCTAGTTTGGAACACC CAAAGTTCAAGTCTTCAGGCAACGCCGTCATCTATTCTGGATAATACCTTTCAAGCTGCA TGGCCCTCAGCAGATGAATCCATCACCAGCAGTATTCCACCACTTGATTTCAGCTCTGGT CCTCCCTCAGCCACTGGCAGGGAACTCTGGTCAGAAAGTCCTTTGGGTGATTTAGTGTCT ACACACAAATTAGCCTTTCCCTCGAAGATGGGCCTCAGCTCTTCCCCAGAGGTTTTAGAG GTTAGCAGCTTGACTCTTCATTCTGTCACCCCGGCAGTGCTTCAGACTGGCTTGCCTGTG GCTTCTGAGGAAAGGACTTCTGGATCTCACTTGGTAGAAGATGGATTAGCCAATGTTGAA GAGTCAGAAGATTTTCTTTCTATTGATTCATTGCCTTCAAGTTCATTCACTCAACCTGTG CCAAAAGAAACAATACCATCCATGGAAGACTCTGATGTGTCCTTAACATCTTCACCATAT CTGACCTCTTCTATACCTTTTGGCTTGGACTCCTTGACCTCCAAAGTCAAAGACCAATTA AAAGTGAGCCCTTTCCTGCCAGATGCATCCATGGAAAAAGAGTTAATATTTGACGGTGGT TTAGGTTCAGGGTCTGGGCAAAAGGTAGATCTGATTACTTGGCCATGGAGTGAGACTTCA TCAGAGAAGAGCGCTGAACCACTGTCCAAGCCGTGGCTTGAAGATGATGATTCACTTTTG CCAGCTGAGATTGAAGACAAGAAACTAGTTTTAGTTGACAAAATGGATTCCACAGACCAA ATTAGTAAGCACTCAAAATATGAACATGATGACAGATCCACACACTTTCCAGAGGAAGAG CCTCTTAGTGGGCCTGCTGTGCCCATCTTCGCAGATACTGCAGCTGAATCTGCGTCTCTA ACCCTCCCCAAGCACATATCAGAAGTACCTGGTGTTGATGATTACTCAGTTACCAAAGCA CCTCTTATACTGACATCTGTAGCAATCTCTGCCTCTACTGATAAATCAGATCAGGCAGAT GCCATCCTAAGGGAGGATATGGAACAAATTACTGAGTCATCCAACTATGAATGGTTTGAC AGTGAGGTTTCAATGGTAAAGCCAGATATGCAAACTTTGTGGACTATATTGCCAGAATCA GAGAGAGTTTGGACAAGAACTTCTTCCCTAGAGAAATTGTCCAGAGACATATTGGCAAGT ACACCACAGAGTGCTGACAGGCTCTGGTTATCTGTGACACAGTCTACCAAATTGCCTCCA ACCACAATCTCCACCCTGCTAGAGGATGAAGTAATTATGGGTGTACAGGATATTTCGTTA GAACTGGACCGGATAGGCACAGATTACTATCAGCCTGAGCAAGTCCAAGAGCAAAATGGC AAGGTTGGTAGTTATGTGGAAATGTCAACAAGTGTTCACTCCACAGAGATGGTTAGTGTG GCTTGGCCCACAGAAGGAGGAGATGACTTGAGTTATACCCAGACTTCAGGAGCTTTGGTG GTTTTCTTCAGCCTCCGAGTGACTAACATGATGTTTTCAGAAGATCTGTTTAATAAAAAC TCCTTGGAGTATAAAGCCCTGGAGCAAAGATTCTTAGAATTGCTGGTTCCCTATCTCCAG TCAAATCTCACGGGGTTCCAGAACTTAGAAATCCTCAACTTCAGAAATGGCAGCATTGTG GTGAACAGTCGAATGAAGTTTGCCAATTCTGTCCCTCCTAACGTCAACAATGCGGTGTAC ATGATTCTGGAAGACTTTTGTACCACTGCCTACAATACCATGAACTTGGCTATTGATAAA TACTCTCTTGATGTGGAATCAGGTGATGAAGCCAACCCTTGCAAGTTTCAGGCCTGTAAT GAATTTTCAGAGTGTCTGGTCAACCCCTGGAGTGGAGAAGCAAAGTGCAGATGCTTCCCT GGATACCTGAGTGTGGAAGAACGGCCCTGTCAGAGTCTCTGTGACCTACAGCCTGACTTC TGCTTGAATGATGGAAAGTGTGACATTATGCCTGGGCACGGGGCCATTTGTAGGTGCCGG GTGGGTGAGAACTGGTGGTACCGAGGCAAGCACTGTGAGGAATTTGTGTCTGAGCCCGTG ATCATAGGCATCACTATTGCCTCCGTGGTTGGACTTCTTGTCATCTTTTCTGCTATCATC TACTTCTTCATCAGGACTCTCCAAGCACACCATGACAGGAGTGAAAGAGAGAGTCCCTTC AGTGGCTCCAGCAGGCAGCCTGACAGCCTCTCATCTATTGAGAATGCTGTGAAGTACAAC CCCGTGTATGAAAGTCACAGGGCTGGATGTGAGAAGTATGAGGGACCCTATCCTCAGCAT CCCTTCTACAGCTCTGCTAGCGGAGACGTGATTGGTGGGCTGAGCAGAGAAGAAATCAGA CAGATGTATGAGAGCAGTGAGCTTTCCAGAGAGGAAATTCAAGAGAGAATGAGAGTTTTG GAACTGTATGCCAATGATCCTGAGTTTGCAGCTTTTGTGAGAGAGCAACAAGTGGAAGAG GTTTAA
- Chromosome Location
- 3
- Locus
- 3q12.3
- External Identifiers
Resource Link UniProtKB ID Q9BZV3 UniProtKB Entry Name IMPG2_HUMAN GeneCard ID IMPG2 HGNC ID HGNC:18362 KEGG ID hsa:50939 NCBI Gene ID 50939 - General References
- Kuehn MH, Hageman GS: Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans. Mol Cell Biol Res Commun. 1999 Aug;2(2):103-10. [Article]
- Acharya S, Foletta VC, Lee JW, Rayborn ME, Rodriguez IR, Young WS 3rd, Hollyfield JG: SPACRCAN, a novel human interphotoreceptor matrix hyaluronan-binding proteoglycan synthesized by photoreceptors and pinealocytes. J Biol Chem. 2000 Mar 10;275(10):6945-55. [Article]
- Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [Article]
- Kuehn MH, Stone EM, Hageman GS: Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders. Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3123-9. [Article]
- Bandah-Rozenfeld D, Collin RW, Banin E, van den Born LI, Coene KL, Siemiatkowska AM, Zelinger L, Khan MI, Lefeber DJ, Erdinest I, Testa F, Simonelli F, Voesenek K, Blokland EA, Strom TM, Klaver CC, Qamar R, Banfi S, Cremers FP, Sharon D, den Hollander AI: Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa. Am J Hum Genet. 2010 Aug 13;87(2):199-208. doi: 10.1016/j.ajhg.2010.07.004. Epub 2010 Jul 30. [Article]
- Meunier I, Manes G, Bocquet B, Marquette V, Baudoin C, Puech B, Defoort-Dhellemmes S, Audo I, Verdet R, Arndt C, Zanlonghi X, Le Meur G, Dhaenens CM, Hamel CP: Frequency and clinical pattern of vitelliform macular dystrophy caused by mutations of interphotoreceptor matrix IMPG1 and IMPG2 genes. Ophthalmology. 2014 Dec;121(12):2406-14. doi: 10.1016/j.ophtha.2014.06.028. Epub 2014 Jul 29. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Interphotoreceptor matrix proteoglycan 2 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Hyaluronic acid approved, vet_approved unknown target binder Details