Zinc transporter ZIP10
Details
- Name
- Zinc transporter ZIP10
- Synonyms
- KIAA1265
- Solute carrier family 39 member 10
- ZIP-10
- ZIP10
- Zrt- and Irt-like protein 10
- Gene Name
- SLC39A10
- UniProtKB Entry
- Q9ULF5Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052331|Zinc transporter ZIP10 MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMTELEPSKFSKQAAENEK KYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHEDLGHDHVSHLDILAVQEG KHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETVEVSVKSDDKHMHDHNHRLRH HHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETNKTQEQSDVKLPKGKRKKKGRKS NENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPGHSHVHLPERNGHDPGRGHQDLDPD NEGELRHTRKREAPHVKNNAIISLRKDLNEDDHHHECLNVTQLLKYYGHGANSPISTDLF TYLCPALLYQIDSRLCIEHFDKLLVEDINKDKNLVPEDEANIGASAWICGIISITVISLL SLLGVILVPIINQGCFKFLLTFLVALAVGTMSGDALLHLLPHSQGGHDHSHQHAHGHGHS HGHESNKFLEEYDAVLKGLVALGGIYLLFIIEHCIRMFKHYKQQRGKQKWFMKQNTEEST IGRKLSDHKLNNTPDSDWLQLKPLAGTDDSVVSEDRLNETELTDLEGQQESPPKNYLCIE EEKIIDHSHSDGLHTIHEHDLHAAAHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSD LKETGIANIAWMVIMGDGIHNFSDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAV LLKAGMTVKQAIVYNLLSAMMAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDML PEMLHGDGDNEEHGFCPVGQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF
- Number of residues
- 831
- Molecular Weight
- 94131.47
- Theoretical pI
- Not Available
- GO Classification
- Functionszinc ion transmembrane transporter activityProcessesnegative regulation of B cell apoptotic process / positive regulation of B cell proliferation / positive regulation of B cell receptor signaling pathway / zinc ion import across plasma membrane
- General Function
- Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity)
- Specific Function
- Monoatomic cation
- Pfam Domain Function
- Zip (PF02535)
- Signal Regions
- 1-25
- Transmembrane Regions
- 411-431 438-458 495-515 687-707 732-752 759-779 801-821
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052332|Zinc transporter ZIP10 (SLC39A10) ATGAAGGTACATATGCACACAAAATTTTGCCTCATTTGTTTGCTGACATTTATTTTTCAT CATTGCAACCATTGCCATGAAGAACATGACCATGGCCCTGAAGCGCTTCACAGACAGCAT CGTGGAATGACAGAATTGGAGCCAAGCAAATTTTCAAAGCAAGCTGCTGAAAATGAAAAA AAATACTATATTGAAAAACTTTTTGAGCGTTATGGTGAAAATGGAAGATTATCCTTTTTT GGTTTGGAGAAACTTTTAACAAACTTGGGCCTTGGAGAGAGAAAAGTAGTTGAGATTAAT CATGAGGATCTTGGCCACGATCATGTTTCTCATTTAGATATTTTGGCAGTTCAAGAGGGA AAGCATTTTCACTCACATAACCACCAGCATTCCCATAATCATTTAAATTCAGAAAATCAA ACTGTGACCAGTGTATCCACAAAAAGAAACCATAAATGTGATCCAGAGAAAGAGACAGTT GAAGTGTCTGTAAAATCTGATGATAAACATATGCATGACCATAATCACCGCCTACGTCAT CACCATCGTTTGCATCATCATCTTGATCATAACAACACTCACCATTTTCATAATGATTCC ATTACTCCCAGTGAGCGTGGGGAGCCTAGCAATGAACCTTCAACAGAGACCAATAAAACC CAGGAACAATCTGATGTTAAACTACCGAAAGGAAAGAGGAAGAAAAAAGGGAGGAAAAGT AATGAAAATTCTGAGGTTATTACACCAGGTTTTCCCCCTAACCATGATCAGGGTGAACAG TATGAGCATAATCGGGTCCACAAACCTGATCGTGTACATAACCCAGGTCATTCTCATGTA CATCTTCCAGAACGTAATGGTCATGATCCTGGTCGTGGACACCAAGATCTTGATCCTGAT AATGAAGGTGAACTTCGACATACTAGAAAGAGAGAAGCACCACATGTTAAAAATAATGCA ATAATTTCTTTGAGAAAAGATCTAAATGAAGATGACCATCATCATGAATGTTTGAACGTC ACTCAGTTATTAAAATACTATGGTCATGGTGCCAACTCTCCCATCTCAACTGATTTATTT ACATACCTTTGCCCTGCATTGTTATATCAAATCGACAGCAGACTTTGTATTGAGCATTTT GACAAACTTTTAGTTGAAGATATAAATAAGGATAAAAACCTGGTTCCTGAAGATGAGGCA AATATAGGGGCATCAGCCTGGATTTGTGGTATCATTTCTATCACTGTCATTAGCCTGCTT TCCTTGCTAGGCGTGATCTTGGTTCCTATCATTAACCAAGGATGCTTCAAATTCCTTCTT ACATTCCTTGTTGCATTAGCTGTAGGAACAATGAGTGGAGACGCCCTTCTTCATCTACTG CCCCATTCTCAGGGTGGACATGATCACAGTCACCAACATGCACATGGGCATGGACATTCT CATGGACATGAATCTAACAAGTTTTTGGAAGAATATGATGCTGTATTGAAAGGACTTGTT GCTCTAGGAGGCATTTACTTGCTATTTATCATTGAACACTGCATTAGAATGTTTAAGCAC TACAAACAACAAAGAGGAAAACAGAAATGGTTTATGAAACAGAACACAGAAGAATCAACT ATTGGAAGAAAGCTTTCAGATCACAAGTTAAACAATACACCAGATTCTGACTGGCTTCAA CTCAAGCCTCTTGCCGGAACTGATGACTCGGTTGTTTCTGAAGATCGACTTAATGAAACT GAACTGACAGATTTAGAAGGCCAACAAGAATCCCCTCCTAAAAATTACCTTTGTATAGAA GAGGAGAAAATCATAGACCATTCTCACAGTGATGGATTACATACCATTCATGAGCATGAT CTCCATGCTGCTGCACATAACCACCACGGCGAGAACAAAACTGTGCTGAGGAAGCATAAT CACCAGTGGCACCACAAGCATTCTCATCATTCCCATGGCCCCTGTCATTCTGGATCCGAT CTGAAAGAAACAGGAATAGCTAATATAGCCTGGATGGTGATCATGGGGGATGGCATCCAC AACTTCAGTGATGGGCTCGCAATTGGTGCAGCTTTCAGTGCTGGATTGACAGGAGGAATC AGTACTTCTATAGCCGTCTTCTGTCATGAACTGCCACATGAATTAGGAGATTTTGCAGTT CTTCTTAAAGCAGGCATGACTGTAAAGCAAGCAATTGTATACAACCTCCTCTCTGCCATG ATGGCTTACATAGGCATGCTCATAGGCACAGCTGTTGGTCAGTATGCCAATAACATCACA CTTTGGATCTTTGCAGTCACTGCAGGCATGTTCCTCTATGTAGCCTTGGTGGATATGCTT CCAGAAATGTTGCATGGTGATGGTGACAATGAAGAACATGGCTTTTGTCCTGTGGGGCAA TTCATCCTTCAGAATTTAGGATTGCTCTTTGGATTTGCCATTATGCTGGTGATTGCCCTC TATGAAGATAAAATTGTGTTTGACATCCAGTTTTGA
- Chromosome Location
- 2
- Locus
- 2q32.3
- External Identifiers
Resource Link UniProtKB ID Q9ULF5 UniProtKB Entry Name S39AA_HUMAN GeneCard ID SLC39A10 HGNC ID HGNC:20861 KEGG ID hsa:57181 NCBI Gene ID 57181 - General References
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- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Zinc transporter ZIP10 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Zinc chloride approved, investigational unknown transporter substrate Details Zinc sulfate, unspecified form approved, experimental unknown transporter substrate Details