Quinoprotein ethanol dehydrogenase
Details
- Name
- Quinoprotein ethanol dehydrogenase
- Synonyms
- 1.1.2.8
- QEDH
- Gene Name
- exaA
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Amino acid sequence
>lcl|BSEQ0016957|Quinoprotein ethanol dehydrogenase MTTRTSPAPAGLLRPSLHCLAFAVALGSAGAALAKDVTWEDIANDDKTTGDVLQYGMGTH AQRWSPLKQVNADNVFKLTPAWSYSFGDEKQRGQESQAIVSDGVIYVTASYSRLFALDAK TGKRLWTYNHRLPDDIRPCCDVVNRGAAIYGDKVFFGTLDASVVALNKNTGKVVWKKKFA DHGAGYTMTGAPTIVKDGKTGKVLLIHGSSGDEFGVVGRLFARDPDTGEEIWMRPFVEGH MGRLNGKDSTVTGDVKAPSWPDDRNSPTGKVESWSHGGGAPWQSASFDAETNTIIVGAGN PGPWNTWARTAKGGNPHDYDSLYTSGQVGVDPSSGEVKWFYQHTPNDAWDFSGNNELVLF DYKAKDGKIVKATAHADRNGFFYVVDRSNGKLQNAFPFVDNITWASHIDLKTGRPVEREG QRPPLPEPGQKHGKAVEVSPPFLGGKNWNPMAYSQDTGLFYVPANHWKEDYWTEEVSYTK GSAYLGMGFRIKRMYDDHVGSLRAMDPVSGKVVWEHKEHLPLWAGVLATAGNLVFTGTGD GYFKAFDAKSGKELWKFQTGSGIVSPPITWEQDGEQYLGVTVGYGGAVPLWGGDMADLTR PVAQGGSFWVFKLPSWDNRTASR
- Number of residues
- 623
- Molecular Weight
- 68122.88
- Theoretical pI
- 7.11
- GO Classification
- Functions2-chloroethanol / alcohol dehydrogenase (acceptor) activity / calcium ion binding / ethanolProcessesethanol oxidationComponentsmembrane / outer membrane-bounded periplasmic space
- General Function
- Ethanol:cytochrome c oxidoreductase activity
- Specific Function
- Catalyzes the oxidation of primary alcohols except for methanol that is a very poor substrate.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0016958|Quinoprotein ethanol dehydrogenase (exaA) ATGACAACAAGAACCTCACCCGCCCCTGCCGGCCTCCTGCGCCCGAGCCTGCACTGCCTC GCCTTCGCCGTCGCCCTGGGCAGCGCTGGCGCCGCGCTGGCCAAGGATGTGACCTGGGAG GACATCGCCAACGACGACAAGACCACCGGCGACGTGCTGCAGTACGGCATGGGCACCCAC GCCCAGCGCTGGAGCCCGCTCAAGCAGGTCAACGCCGACAACGTGTTCAAGCTGACCCCG GCCTGGTCGTACTCCTTCGGCGACGAGAAACAGCGCGGCCAGGAGTCCCAGGCCATCGTC AGCGACGGCGTGATCTACGTGACCGCCTCCTACTCGCGGCTGTTCGCCCTCGACGCGAAG ACCGGCAAGCGCCTGTGGACCTACAACCACCGCCTGCCCGACGACATCCGCCCGTGCTGC GACGTGGTCAACCGCGGCGCCGCGATCTATGGCGACAAGGTGTTCTTCGGCACCCTCGAC GCCTCGGTGGTGGCGCTGAACAAGAACACCGGCAAGGTGGTGTGGAAGAAGAAGTTCGCC GATCACGGCGCCGGCTACACCATGACTGGCGCGCCGACCATCGTGAAGGACGGCAAGACC GGCAAGGTCCTGCTGATCCACGGCAGTTCGGGCGACGAGTTCGGCGTGGTCGGCCGCCTG TTCGCCCGCGATCCGGATACCGGCGAGGAAATCTGGATGCGTCCCTTCGTCGAAGGCCAC ATGGGCCGCCTGAACGGCAAGGACAGCACGGTGACCGGCGACGTCAAGGCGCCCTCCTGG CCGGACGATCGCAACTCGCCGACCGGCAAGGTCGAGTCGTGGAGCCACGGCGGCGGCGCT CCCTGGCAGAGCGCCAGCTTCGACGCCGAGACCAACACCATCATCGTCGGCGCCGGCAAC CCCGGCCCGTGGAACACCTGGGCGCGCACCGCCAAGGGCGGCAACCCGCACGACTACGAC AGCCTCTACACCTCCGGCCAGGTCGGGGTGGACCCGAGCAGCGGCGAGGTGAAGTGGTTC TACCAGCACACCCCCAACGACGCCTGGGACTTCTCCGGCAACAACGAACTGGTGCTGTTC GACTACAAGGCCAAGGACGGCAAGATCGTCAAGGCCACCGCCCACGCCGACCGCAACGGC TTCTTCTATGTGGTCGACCGCAGCAACGGCAAGTTGCAGAACGCCTTCCCCTTCGTCGAC AACATCACCTGGGCCAGCCACATCGACCTGAAGACCGGCCGCCCGGTGGAGCGCGAGGGC CAGCGCCCGCCGCTGCCGGAACCGGGGCAGAAGCATGGCAAGGCGGTGGAAGTATCGCCG CCGTTCCTCGGCGGCAAGAACTGGAACCCGATGGCCTACAGCCAGGACACCGGCCTGTTC TACGTGCCGGCCAACCACTGGAAGGAAGACTACTGGACCGAGGAGGTCAGCTATACGAAG GGCAGCGCCTACCTTGGCATGGGCTTCCGGATCAAGCGCATGTACGACGACCACGTCGGC AGCCTGCGCGCCATGGACCCGGTCAGCGGCAAGGTGGTCTGGGAACACAAGGAACACCTG CCGCTCTGGGCCGGGGTGCTGGCCACCGCCGGCAACCTGGTGTTCACCGGCACCGGCGAC GGCTACTTCAAGGCCTTCGACGCGAAGAGCGGCAAGGAGCTGTGGAAATTCCAGACCGGC AGCGGCATCGTCTCGCCACCGATCACCTGGGAACAGGACGGCGAGCAGTACCTCGGCGTG ACCGTCGGCTACGGCGGCGCCGTGCCGCTGTGGGGCGGCGACATGGCCGACCTGACCCGG CCGGTGGCCCAGGGCGGTTCCTTCTGGGTATTCAAGCTGCCCAGCTGGGACAACCGCACC GCCAGCCGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9Z4J7 UniProtKB Entry Name EXAA_PSEAE GenBank Gene ID AJ009858 - General References
- Diehl A, von Wintzingerode F, Gorisch H: Quinoprotein ethanol dehydrogenase of Pseudomonas aeruginosa is a homodimer--sequence of the gene and deduced structural properties of the enzyme. Eur J Biochem. 1998 Oct 15;257(2):409-19. [Article]
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- Schobert M, Gorisch H: Cytochrome c550 is an essential component of the quinoprotein ethanol oxidation system in Pseudomonas aeruginosa: cloning and sequencing of the genes encoding cytochrome c550 and an adjacent acetaldehyde dehydrogenase. Microbiology. 1999 Feb;145 ( Pt 2):471-81. [Article]
- Keitel T, Diehl A, Knaute T, Stezowski JJ, Hohne W, Gorisch H: X-ray structure of the quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: basis of substrate specificity. J Mol Biol. 2000 Apr 7;297(4):961-74. [Article]