Reaction: Aprepitant to 2 products
N-dealkylationMetabolism of Aprepitant
Aprepitant is converted to (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine and 5-oxo-1,4-dihydro-1,2,4-triazole-3-carbaldehyde by Cytochrome P450 3A4, Cytochrome P450 3A5, Cytochrome P450 1A2 and 1 other enzyme.
- Reaction
- Direction
What you can answer from here — as of October 27, 2017
4EnzymesEach linked to its target cardListed above
Which other drugs are metabolised by Cytochrome P450 3A4, Cytochrome P450 3A5, and Cytochrome P450 1A2, and which of those pairings are clinically significant?
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