Reaction: Dolutegravir to 1 product

Reaction
Reaction type
glucuronidation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Castellino S, Moss L, Wagner D, Borland J, Song I, Chen S, Lou Y, Min SS, Goljer I, Culp A, Piscitelli SC, Savina PM: Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans. Antimicrob Agents Chemother. 2013 Aug;57(8):3536-46. doi: 10.1128/AAC.00292-13. Epub 2013 May 13. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferase 1-1Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-3Not AvailableNot Availableconfirmed
UDP-glucuronosyltransferase 1-9Not AvailableNot Availableconfirmed