Reaction: Estradiol to 1 product

Reaction
Estradiol
DB00783
2-hydroxyestrone
DBMET00248
Reaction type
2-hydroxylation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Longcope C, Gorbach S, Goldin B, Woods M, Dwyer J, Warram J: The metabolism of estradiol; oral compared to intravenous administration. J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8. [Article]
  2. Brown CM, Reisfeld B, Mayeno AN: Cytochromes P450: a structure-based summary of biotransformations using representative substrates. Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742 . [Article]
  3. Intech open: The role of metabolism in the estrogenic activity of endocrine disrupting chemicals [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A4Not AvailableNot Availableconfirmed
Cytochrome P450 1A2Not AvailableNot Availableconfirmed
Cytochrome P450 1A1Not AvailableNot Availableimplied