Cytochrome P450 1A1

BE0003543ProteinHumansCYP1A1

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:14559847, PubMed:15041462, PubMed:15805301, PubMed:18577768, PubMed:19965576, PubMed:20972997). It is acted on by 122 drugs in DrugBank.

Gene name
CYP1A1
UniProtKB entry
P04798Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
512 residues · 58,165 Da
Also known as
1.14.14.1 · CYPIA1 · Cytochrome P450 form 6 · Cytochrome P450-C · Cytochrome P450-P1

Resolves to

Protein
UniProtP04798UniProt nameCP1A1_HUMAN
Gene
HGNCHGNC:2595NCBI Gene1543GenBank181276GeneCardsCYP1A1
Pharmacology
IUPHAR/GtoPdb1318KEGGhsa:1543
Structure
PDB4I8VPDB6DWMPDB6DWN
Drugs

What you can answer from here — as of September 07, 2019

122DrugsApproved to experimental, with action, bond type and pharmacological action
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69Metabolic reactionsDrug transformations it catalyses, substrate to product
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36GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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220+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 1A1, how selective are they, and which programs against it are still in active trials?

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